- 7 CBD Oil Side Effects You Should Watch Out For
- CBD Oil Side Effects
- 1) Dry Mouth
- 2) Digestive Issues
- 3) Drowsiness and Fatigue
- 4) Dizziness
- 5) Possible Liver Damage
- 6) Irritability
- 7) Immune Suppression
- Kidney Health
- Risk Populations
- Drug Interactions
- Creams & Gels
- 1) Drink More Water
- 2) Find Additive-Free Products
- 3) Take it Before Sleep
- 4) Increase Wakefulness Naturally
- 5) Support Your Liver
- 6) Don’t Take Megadoses
- 7) Monitor Your Immune Response
- 7 Potential CBD Oil Side Effects You Need to Know
- CBD Oil Side Effect #1: Dry Mouth (Cotton Mouth)
- How to Combat CBD Induced Dry Mouth
- CBD Oil Side Effect #2: Lightheadedness
- How to Combat Lightheadedness Induced by CBD
- CBD Oil Side Effect #3: Drowsiness
- CBD Oil Side Effect #4: Low Blood Pressure
- Tips to Combat Low Blood Pressure
- CBD Oil Side Effect #5: Inhibition of Hepatic Drug Metabolism
- CBD Oil Side Effect #6: Increased Parkinson’s Disease Tremors
- Tips to Combat Increased Parkinson’s Tremors
- CBD Oil Side Effect #7: Diarrhea
- How to Combat Cannabidiol Caused Diarrhea
- Final Thoughts
- CBD Oil Side Effects, Interactions, Dosage, and Warning
- CBD Oil Side Effects On Body
- Is CBD Oil Addictive
- Can CBD Get You High?
- Allergic Reaction to CBD Oil
- CBD Oil Interactions with Medications
- How Long Does CBD Oil Effects Last
- What Are the Health Benefits of CBD Oil?
7 CBD Oil Side Effects You Should Watch Out For
CBD oil is believed to be generally safe and well-tolerated, but it is not free of side effects. Read on to learn which adverse effects you should watch out for when using CBD oil, how the delivery form influences them, and what you can do to reduce your risk.
CBD Oil Side Effects
First, it is important to remember that CBD oil is considered experimental and investigational and far more clinical studies are needed before we can make any firm conclusions about its supposed benefits .
Similarly, it’s an insufficiently investigated supplement with a relatively unknown safety profile. The list of side effects listed in this article is, therefore, not a definite one.
So, make sure to speak with your doctor before starting on a CBD oil regimen.
With the recent legalization of CBD oil in many states worldwide, its popularity is booming and people are taking it for not only its FDA-approved use for seizures, but also conditions such as :
- Chronic pain
- Sleep disorders
An advantage of CBD oil is that it’s considered generally safer and causes fewer adverse effects than the drugs typically used for these conditions. Chronic doses of up to 1500 mg/day were tolerated well in multiple studies [3+, 4].
Un THC, CBD doesn’t cause behavioral and psychological side effects. What’s more, it may even reduce some of them such as anxiety, psychosis, and memory loss [5, 6, 7, 8].
Nevertheless, there are some potential side effects of CBD oil that you should watch out for. Below is a detailed overview of the most common ones.
1) Dry Mouth
Whether you use them for recreational or medicinal purposes, cannabis products will often make your mouth feel as if it were stuffed with cotton balls. Almost 12% of 1500 people responding to a survey about CBD use experienced dry mouth, making it the most common adverse effect .
Stimulation of the CB1 and CB2 receptors in the salivary glands reduces saliva secretion, which makes the mouth feel dry. The well-known cannabis compound THC activates these receptors directly. In turn, CBD raises the levels of an activator naturally produced in the body – the cannabinoid anandamide [9, 10, 11, 12].
2) Digestive Issues
Both CBD oil supplements and the FDA-approved CBD medicine Epidiolex have been reported to cause digestive issues such as [2, 4]:
- Nausea and vomiting
- Increased or reduced appetite
- Weight loss or gain
Because preliminary research suggests that CBD improves rather than causes nausea and diarrhea, these effects most ly result from the irritating effects of other ingredients (e.g., carrier oils) on the bowels [13, 14, 15].
Alternatively, the loose regulation of supplements may allow for excessive CBD levels in products or harmful contaminants such as pesticides, heavy metals, and solvents [16+, 17].
In turn, the endocannabinoid system has a role in promoting appetite. The mixed effects of CBD on appetite and weight seen in different studies may be due to its dual effect: it blocks the CB1 and CB2 receptors but boosts the levels of their activator anandamide [18, 19, 11].
If you experience digestive issues from using CBD oil, tell your doctor. He or she may recommend reducing the dose or shifting to another brand.
3) Drowsiness and Fatigue
People taking CBD oil often report feeling sleepy and tired. Indeed, this side effect was observed in early clinical trials and one of the most common uses of CBD oil is to improve sleep disorders [20+].
If the symptoms are very severe, you shouldn’t drive or operate heavy machinery.
The effect of CBD on sleep seems to be biphasic: high doses may increase sleeping time, lower amounts may promote wakefulness. Additionally, levels of endocannabinoid receptors depend on the circadian rhythm. This may explain why CBD tends to cause drowsiness later in the day but has the opposite effect in the morning [21, 22, 23].
High doses of CBD lowered blood pressure in a small trial on 9 people. In turn, THC seems to have a more complex effect: it slightly raises blood pressure in people lying down but increases the risk of sudden blood pressure drops when standing up [24, 25+].
As a result, a common adverse effect of CBD – both alone and with equal amounts of THC (nabiximols) – is feeling dizzy and light-headed [26, 27, 28].
If your blood pressure drops too much, you may faint. The risk is especially high in people diagnosed with low blood pressure or on blood pressure medications – such as diuretics, ACE inhibitors, and beta-blockers. These people should be especially cautious with CBD oil and never try it out without discussing it with their doctor.
5) Possible Liver Damage
Several trials testing CBD for seizures found possible liver damage (high transaminases ALT and AST) in 9-25% of the people. The risk increased with the dose and was highest in people also taking the anti-seizure drug valproate, which is known to cause liver injuries [29+, 30, 31, 32, 33, 34].
Similarly, CBD caused signs of liver toxicity (high transaminases, alkaline phosphatase, and bilirubin) in mice and dogs. However, the doses were generally higher than those used in human trials [35, 36, 37].
Make sure to talk to your doctor, especially if you are taking valproate, and never exceed the recommended CBD oil dose to reduce your risk of liver damage.
CBD is often used to curb anxiety, although research suggests it has “inverted U-shaped” effects: moderate doses, but not low or high amounts, may be effective for a range of anxiety disorders and stressful situations [38, 39].
In contrast, very high doses may even trigger anxiety and irritability. This was the case in 7-9% of the children in 2 clinical trials using CBD for seizures and autism [40, 41].
The effect probably involves the TRPV1 receptor, the activation of which increases the brain’s response to stressful situations .
CBD boosts the naturally-produced cannabinoid anandamide. While moderate anandamide levels activate CB1 receptors and curb anxiety, high amounts may worsen it by binding to TRPV1. CBD also activates this receptor directly, further contributing to the potential anxiety-triggering effects [43, 44, 11, 45].
7) Immune Suppression
CBD may reduce the immune response. It prevents T cells from dividing, migrating to inflammation sites, and producing pro-inflammatory cytokines. This may be beneficial in people with autoimmune conditions such as rheumatoid arthritis or multiple sclerosis [46, 47, 48, 49, 50, 51, 52].
The downside of blocking the immune response is that it may make people with weakened immune systems more prone to infections. Thus, people on immunosuppressants or with conditions such as HIV, diabetes, and Down syndrome might want to avoid it .
CBD didn’t damage the kidneys in clinical trials. In fact, researchers believed it protected against kidney injury and inflammation in numerous animal studies [54, 55, 56, 57, 58]. Remember that larger and better designed clinical trials are needed before these findings are conclusive.
Though more clinical trials are needed, the current evidence suggests CBD oil will not harm your kidneys at normal doses.
On the other hand, people with kidney disease should probably avoid THC-containing medical marijuana without consulting a doctor.
According to a recent review, THC may worsen kidney health and increase urination by activating CB1 receptors. Remember that, un THC, CBD blocks these receptors. However, CBD may indirectly activate them by increasing anandamide levels in the body [59+].
Lastly, avoid synthetic cannabinoids at all costs (products “spice” and “K2” sold in smoke shops). These chemicals caused sudden and severe kidney injury in several cases [59+].
CBD altered the levels of two drug transporters in placental cells. This suggests that taking CBD oil during pregnancy may increase the exposure of the fetus to any drugs that the mother takes. Pregnant women should avoid CBD oil in any case, since safety data are lacking .
Taking THC-containing CBD oil during pregnancy and breastfeeding is particularly dangerous, since THC may reduce growth and cause brain developmental anomalies in babies [61+].
Because there are no studies testing its safety in children below 2 years old, it’s better to avoid giving them CBD oil unless prescribed by a doctor.
CBD is thought to be safe in older children, but they may be more sensitive to THC and toxic contaminants such as heavy metals and pesticides than adults. Be sure to use high-quality, THC-free CBD in children and consult the doctor first.
Most drugs are broken down by liver enzymes. Among them, cytochrome (CYP) P450 plays a key role. A single CBD dose blocks several CYP enzymes, such as:
By doing so, it may slow the breakdown of several drugs and enhance their effects [62, 63, 64, 65, 66].
Indeed, CBD reduced the breakdown of the sedative hexobarbital, the anti-seizure drug clobazam, and the blood thinner warfarin in humans. It had the same effect on the immunosuppressant cyclosporin and the cannabis compound THC in cells [67, 68, 69, 70].
On the other hand, repeated CBD doses can increase the levels of some enzymes of this group and reduce the effects of the drugs they break down [71, 72, 73, 74].
Plus, CBD itself is broken down by CYP enzymes, especially by CYP34A and CYP2C19. Drugs that block these enzymes (such as ketoconazole and ritonavir) will enhance its effects, while those that activate them (such as phenobarbital and rifampicin) will have the opposite effect [75, 4].
If you are on prescription medication and plan to use CBD oil, ask your doctor about potential interactions and dose readjustment. Additionally, avoid combining CBD oil with grapefruit or other supplements that block the same liver enzymes (such as St John’s wort or watercress).
While rapid-release forms (mouth sprays and oil tinctures) deliver CBD directly into your bloodstream, slow-release forms (capsules, edibles, and teas) have to pass your digestive system first. This means their ingredients may irritate your bowels and give you nausea and diarrhea [76+, 77].
However, rapid-release forms will release CBD faster, so you may experience both wanted and unwanted effects sooner [76+, 77].
And since tinctures and sprays are directly applied in the mouth, they will quickly reach the salivary glands and cause dry mouth. Mouth sprays may also cause a stinging sensation and even burns, especially if they contain alcohol [9, 78].
Vapes bypass the digestive system without irritating your bowels, but they may trigger the other adverse effects faster [76+, 77].
Vaping is considered safer than smoking cigarettes or joints because the oil is heated at lower temperatures that produce fewer toxic byproducts [76+ 79].
However, the additives used as flavorings and thinning agents in vaping oils may still pose some hazards. Although they are normally food-grade, they may release harmful compounds (including the cancer-causing formaldehyde) when vaporized. Their heavy use may lead to [80, 79, 81+]:
- Dry throat
- Lung injury
- Fat particles entering the lungs (lipoid pneumonia – rare)
For instance, one man developed severe lung damage from vaping CBD oil [82+].
Creams & Gels
Creams and gels act locally on the application site and don’t release CBD into the gut or bloodstream. This means they will not cause most of the adverse effects previously described [76+].
However, they may cause allergic reactions with itching, redness, and rashes on the skin. It’s important to note that the reactions can be caused by either CBD or other ingredients in the formulation [83+, 84+].
1) Drink More Water
The best way to reduce dry mouth when using CBD oil is to drink plenty of water and other hydrating liquids before, during, and after consumption.
2) Find Additive-Free Products
You can reduce the risk of digestive issues by choosing forms that bypass the gut and directly release CBD into your bloodstream such as vapes, mouth sprays, and oil tinctures. High-quality oils without additives may also irritate your bowels less.
3) Take it Before Sleep
If you feel drowsy or light-headed after taking CBD oil, you may need to reduce the dose or take it only before sleep.
4) Increase Wakefulness Naturally
Drinking coffee or tea will help you both stay awake and raise your blood pressure, but it also causes many side effects. Try to get more sunlight first thing in the morning, as it will energize you and help you get better sleep at night. We talk about other natural ways to increase wakefulness in this post.
5) Support Your Liver
Avoid combining CBD with the anti-seizure drug valproate. Additionally, make sure not to exceed the dose and regularly monitor your liver function to reduce your risk of liver damage. Eggs (choline), artichokes, NAC, and probiotics also support liver health. Read more foods and supplements that are good for the liver here.
6) Don’t Take Megadoses
Only very high CBD doses may cause irritability. Make sure not to exceed the dose and try reducing it if you notice this symptom.
7) Monitor Your Immune Response
If you have a weakened immune system, you should consult your doctor before taking CBD oil. You may need to avoid CBD or take a lower dose.
Additionally, you may also want to look into balancing your Th1/Th2 immune response. If you have a slightly weaker immune system and are prone to allergies, you are probably Th2-dominant.
7 Potential CBD Oil Side Effects You Need to Know
With all of the research studies uncovering the incredible health benefits of cannabidiol (CBD) oil, you may begin to question whether or not hemp derived CBD oil has any potentially harmful side effects.
As with any drug, pharmaceutical or holistic, cannabidiol has effects on your body. So today we are going to discuss what causes these side-effects and the steps you can take to combat them.
But before you automatically jump to the conclusion that CBD has harmful side-effects, I’d to say that the effects discussed below are rare and occur in only the most extreme cases.
Potential side effects that may be experienced with the use of CBD include:
- Dry Mouth
- Low Blood Pressure
- Inhibition of Hepatic Drug Metabolism
- Increased Tremors in Parkinson’s Disease Patients
As you can see, when the side-effects of cannabidiol are compared to those of pharmaceuticals they are extremely minor!
Let’s now look into the potential side effects of CBD in greater depth.
CBD Oil Side Effect #1: Dry Mouth (Cotton Mouth)
Ahh the age old struggle with cotton mouth! Dry mouth is a common side-effect of smoking cannabis and the experienced smoker is well aware of this. But when it comes to organic CBD oil, dry mouth can also be a side-effect.
The unpleasant dry sensation in your mouth is a result of the involvement of your body’s endocannabinoid system in the inhibition of salvia secretion.
This was discovered during a 2006 study, which discovered that both cannabinoid receptors CB1 and CB2 are located in the submandibular glands, which are responsible for the production of salvia.
Once the CB1 and CB2 receptors are activated through the use of cannabidiol, the production of saliva becomes altered. As a result, your mouth begins to feel as dry as the Sahara desert. When experiencing mouth dryness, or better known as cotton mouth, there is no need to worry it simply means you’re thirsty!
How to Combat CBD Induced Dry Mouth
When experiencing dry mouth following the consumption of hemp derived CBD oil, nothing can satisfy your thirst quite a nice tall glass of cool H20!
So the next time you start to feel cotton mouth kicking in, all as you need to do is hydrate yourself with your favorite beverage, but water is the most effective.
CBD Oil Side Effect #2: Lightheadedness
Another reported side effect of cannabidiol, although not common, is lightheadedness.
This is typically experienced in users administering higher doses of CBD and is caused by a drop in blood pressure. Although this CBD side effect is temporary, it can be a scary experience for an inexperienced user of cannabidiol.
If you experience lightheadedness after administering a dose of CBD, there is no need to freak out, here is what you should do.
How to Combat Lightheadedness Induced by CBD
When or if lightheadedness begins to kick in, you should first stop what you’re doing and sit down to regain your composure. To further reduce this side effect, drinking a cup of hot tea or coffee may provide some alleviating assistance.
CBD Oil Side Effect #3: Drowsiness
It’s extremely well-known that cannabidiol is an effective treatment option for sleep related problems such as insomnia. But if you do not have difficulty sleeping, then drowsiness may be an unwanted side effect that can impact your plans for the day.
Typically, this side effect is only experienced when consuming larger doses of CBD at once or throughout your day.
If you begin to feel drowsy after using cannabidiol, you should be sure to not operate any heavy duty machinery or drive a vehicle. Although we do not recommend doing either after using CBD for at least a few hours. Remember safety first folks!
However, in most cases CBD acts as a wake-inducing agent. If you have never used CBD before, you should allow the effects of this incredible cannabinoid to kick in before driving. Allowing you to gauge whether or not you’ll experience drowsiness.
CBD Oil Side Effect #4: Low Blood Pressure
Although minute, consumption of higher doses of CBD can cause a drop in your blood pressure. This often begins to go into effect within a few short minutes of cannabidiol entering your body. When your blood pressure begins to drop, that’s when you begin to experience feelings of lightheadedness as discussed above.
So if you are looking to use CBD for treatment, but you are currently using medication for blood pressure, you should first speak with your doctor before using cannabidiol oil.
Tips to Combat Low Blood Pressure
Following the consumption of hemp derived CBD oil, if you begin to experience low blood pressure that causes you to feel lightheaded you should sit down and take a deep breath. And as mentioned above, drinking a cup of coffee or hot tea may also provide subside this side effect.
CBD Oil Side Effect #5: Inhibition of Hepatic Drug Metabolism
When discussing CBD side effects, the inhibition of hepatic drug metabolism can be looked at as nothing more than a minor side effect at best.
Let me explain:
CBD can cause the inhibition of hepatic drug metabolism, while also decreasing the activity of p-glycoprotein. Through the inhibition of activity in certain liver enzymes known as cytochrome P450, CBD can actually interact with some types of pharmaceutical medications.
Which as a whole, these liver enzymes are responsible for metabolizing the vast majority of pharmaceutical medications that are used to treat humans. Assuming you’re a human, if you take a high dose of cannabidiol oil it can temporally counteract the activity of cytochrome P450 enzymes. Altering the way these drugs are metabolized inside your body.
At most, this is a very minor CBD side effect and you shouldn’t worry. In fact, the deactivation of cytochrome P450 enzymes is how CBD neutralizes the sometimes overwhelming psychoactive effects of THC.
CBD Oil Side Effect #6: Increased Parkinson’s Disease Tremors
During the early days of cannabidiol research, one study found that the use of CBD in larger doses increases tremors that are associated with Parkinson’s Disease.
However, recent studies have suggested the opposite. Showing that cannabidiol is a safe and beneficial treatment option for patients diagnosed with Parkinson’s disease.
Tips to Combat Increased Parkinson’s Tremors
First off, if you or a loved one is diagnosed with Parkinson’s disease you should first consult with a doctor before starting CBD treatment. We also recommend starting out with smaller doses when beginning treatment with CBD.
Although unly, if you or a loved one notice the level of tremors increasing after consuming cannabidiol, reducing the dosage amount should help to minimize this potential side effect.
CBD Oil Side Effect #7: Diarrhea
Although CBD is known for its regulating actions of your endocannabinoid system, it can also cause diarrhea. This side effect can be quickly corrected, as it’s typically associated with either the dosage amount or your overall cannabidiol tolerance.
How to Combat Cannabidiol Caused Diarrhea
So if you begin to experience diarrhea following CBD intake, you should either reduce your total dosage or consult with your doctor before resuming use. But just to be safe, we recommend that you bring this side effect up with your doctor during your next appointment.
As you can see, the potential side effects that may potentially be experienced in a small set of CBD users are far less harmful than those of prescription drugs.
The CBD oil benefits greatly outweigh the potential side effects of cannabidiol. But that doesn’t mean it isn’t important for to to not pay attention in the event that any of these CBD side effects arise. And you should discuss them with your doctor.
Have you experienced any of the side effects discussed above? If so, I’d love to hear about your experiences as well as what you did to reduce the side effects in the comments section below!
Running low on CBD products? Stock up on all of your favorite CBD infused topicals/tinctures, CBD vape juice, Isolate crystals, vape cartridges, and gummies!
CBD Oil Side Effects, Interactions, Dosage, and Warning
The concept of CBD oil effects has always brought controversies, especially among those individuals who haven’t grasped the basics of CBD benefits. Most people always assume that just because both CBD and THC are obtained from marijuana then they must be similar in properties and effects.
But let’s clear the misconception and settle for facts:
It is true that both CBD and THC are cannabinoids – a group of 104+ compounds that can be obtained from marijuana. However, the major difference between CBD and most other product among the cannabinoids is that CBD doesn’t have any psychoactive effects. Simply put, CBD cannot make you high.
The inability of CBDto cause any psychoactive effects has improved its usage both at home and in the hospital. Natural non-psychoactive products including CBD oil and hemp oil are becoming daily routine forms of treatments as natural supplements or as alternative therapeutic agents to conventional medicine.
Since all pharmacologically active substances are not 100% risk-free, it is prudent to assume that even though CBD doesn’t have psychoactive effects THC, it surely has some other effects on the body. As with all products, it is important to fully grasp the basics of what CBD does to your body (pharmacodynamics) and what your body does to CBD (pharmacokinetics.)
With this information in place, you will know exactly the right amount of CBD to use and the potential effects to expect – including ways on how to manage CBD effects when they occur.
CBD Oil Side Effects On Body
Before we get to know the effects of CBD on the body, we have to understand the mechanisms which allow it to affect the body in the first place.
In the body, there is a system called the endocannabinoid system (ECS). The system is what allows the products of cannabis (essentially all cannabinoids) to cause their effects in the body. This system has receptors called cannabinoid receptors which are designated the abbreviations: CB1 and CB2 receptors.
You may be wondering why we even have receptors for cannabis in the body. Does it mean our body prepares us to get high? – or use marijuana?
Certainly not! There are certain lipid-based endogenous neurotransmitters called endocannabinoids in our body.
These neurotransmitters are what naturally bind to these endocannabinoid receptors. However, they share certain similarities with the cannabinoids from marijuana, hence the reason why cannabinoids can easily bind to these CB receptors in the body.
But here is the real deal about these receptors and how they work.
CB1 receptors are located in the central nervous system. The central nervous system includes the brain and the spinal cord.
Essentially, these receptors work to regulate and/or alter the biochemistry of the body depending on when and how they are stimulated. The major exogenous substance that interacts actively with these CB1 receptors is tetrahydrocannabinol.
It is by far the major component of the cannabinoid family obtained from the cannabis plant. THC has the potential to make you high because it is able to bind to these receptors located in the central nervous system.
On the other hand, CB2 receptors are located in the peripheral nervous system (all the nervous system excluding the brain and the spinal cord) and in the white blood cells (the group of cells which help with body immunity against infectious agents.)
The chief function of CB2 receptors is to work with white blood cells for the purpose of improving and regulating the activities of the body’s immune system.
It has been proven that CBD characteristically binds selectively to these CB2 receptors without actually binding to CB1 receptors. This is the basic reason why CBD doesn’t have any psychoactive effects. Instead, its binding to CB2 receptors results in the health effects that are commonly cited as beneficial effects of CBD.
With the basic knowledge about CBD oil benefits in place, what then are its side effects on the body?
Studies, such as this review done in 2017, have confirmed the often-described safety profile of using CBD. From this study, it appeared that the most common side effects of CBD are the following:
- Loss of Appetite
- Changes in body weight
Aside from the aforementioned, some patients who use CBD reported to have experienced the following adverse effects:
- Drying of the mouth
- Change in mood
Essentially, the side effects of CBD on the human body are not quite serious. They are actually nonspecific and proves that CBD products are way safer than the contemporary medications that are used to manage conditions similar to those in which CBD is indicated for therapeutic use.
Is CBD Oil Addictive
The simple answer to this question is No.
CBD is not addictive. Actually, one of the most advanced use of CBD is in the treatment of certain symptoms related to substance abuse.
CBD is very useful in relieving the cravings and the anxiety experienced by individuals who are suffering from various forms of addiction.
It is not a surprise that everyone who has been taught and acclimatized to the fact that marijuana is a bad substance will be left in awe when you try to explain that CBD is not addictive. But in this world of technological advancement and a tremendous increase in knowledge, ignorance is just but a choice.
The explanation that CBD is not actually addictive came from the famous Word Health Organization which examined and scrutinized the pharmacologic profile of CBD. In their review of CBD, the World Health organization evaluated the effects of administering cannabidiol dosages in healthy individuals to test for the potential of abuse.
The results from the study showed that CBD is just as innocuous as the placebo used for the experiment. This review by WHO has a significant impact on turning the hearts of the masses towards agreeing to the fact that CBD is not addictive.
By dispelling the misunderstandings that have hampered the widespread use of CBD, the WHO might have just boosted the market value of CBD.
Can CBD Get You High?
No, CBD cannot make you high. As mentioned earlier, it has no psychoactive effects. Though it has the ability to make you feel relaxed, which some people will equate to being high – but that’s not true.
The reason why substances THC are capable of making someone high is because they a directly bind to CB 1 receptors. CBD on the other hand bind only to CB 2 receptors which have no association with any central nervous system effects.
Usually, the benefits of CBD are overshadowed by fears that it can get you high just because it is classified in the same category as THC. Nevertheless, there are several research studies being done on CBD, and certainly or so, their results will help reinstate the belief in the potential benefits of CBD.
Allergic Reaction to CBD Oil
Medically speaking, allergic reactions can be caused by literally any substances that get on or into the body. What causes allergies are substances called allergens. Everything is actually an allergen – what creates the difference is the susceptibility of an individual to those allergens.
For instance, one person can be allergic to plant products, while another person can be allergic to animal products. Others may not even elicit any allergic reactions at all to anything.
In susceptible individuals, an allergen is capable of activating the immune system, so much so that the immune system destroys the tissues of the body.
With the background of allergies in place: what do you think about the potential of CBD to cause allergic reactions?
Ideally, people can have allergic reactions to CBD just as readily as they get allergies to pollen and animal dander. Over the past few years, the incidences of CBD allergies have increased owing to the widespread legalization of cannabis use.
What causes these allergies?
At least 50 million Americans have been diagnosed with allergic reactions to CBD. CBD can cause potential allergies to people who are susceptible to cannabis allergens.
If you are allergic to the pollen of marijuana, then you will certainly be allergic to CBD. Usually, susceptibility to CBD allergies comes from sensitization and sensitization comes from exposure.
There are several ways in which you can get exposed to marijuana to aggravate sensitization. You can be exposed to marijuana through the following ways:
- Smoking marijuana either actively or passively.
- Inhaling the pollen of marijuana
- Eating marijuana
- Touching marijuana
Research shows that getting sensitized against marijuana will make you susceptible to allergies if you take CBD products. One particular strain of cannabis called Cannabis sativa is particularly known to cause serious irritation and allergies.
How will you know that you are having an allergic reaction to CBD?
Allergies will always present with certain symptoms which may or may not be specific. Symptoms of CBD allergy include:
- Incessant dry cough
- Itchiness of the eyes
- Nausea which may or may not be accompanied by vomiting
- Watery and redness of the eyes
- Sore throat
Manifestations in the skin secondary to handling CBD products may include:
- Dryness of the skin
- Blistering of the skin
- Erythema (redness) of the skin
These symptoms of allergies are always immediate just after an exposure. However, they may delay and start about an hour or several hours later following an exposure.
CBD Oil Interactions with Medications
Perhaps the most studied action of CBD is its effect on the hepatic metabolism of drugs. Studies have shown that CBD interacts with enzymes such as cytochrome P450 which metabolize drugs.
This means CBD can alter the metabolism of all drugs that are metabolized using the Cytochrome P450 enzymes.
Approximately 60% of all pharmaceutical mediations are metabolized by these cytochrome P450 enzymes – specifically the enzyme CYP3A4. What’s more, is that this is the same enzyme which metabolizes CBD in the body.
As a result, a medication that inhibits the enzyme CYP3A4 can interfere with the metabolism of CBD. This will ultimately raise the levels of CBD in the body – potentially aggravating its side effects.
Because of these reasons, you should not take any prescription medication simultaneously with any CBD product before consulting your doctor. In certain circumstances, you may be forced to either stop CBD products and stick to prescription medicine or just adhere to CBD only.
If you are not sure about what you should do in terms of medication intake, you can seek advice from a professional such as a pharmacist, CBD expert or your doctor.
How Long Does CBD Oil Effects Last
The answer to this question may not be very conclusive. The biochemistry of every individual is different and CBD may react differently with every person.
Some people may experience effects acutely while others may experience these effects later. Irrespective of these differences, clinical observations show that the effects of CBD oil can last for between four to six hours though the onset of action for CBD is just between 20 to 30 minutes.
CBD is certainly one of those products with immeasurable benefits and little side effects. It is very effective when used to manage the condition in which it is indicated for use.
However, the widespread use of CBD has still not been achieved because most people still hold to the misconception that CBD is equally detrimental as cannabis. The good news is that many studies are being carried out to help in enlightening the people about the potential benefits of CBD.
But till then, what do you think? Is CBD a better alternative treatment option or the risks far much outweigh the benefits?
If you wish to learn more about CBD oils, benefits, and more, feel free to check our homepage.
- Stout SM, Cimino NM. Exogenous cannabinoids as substrates, inhibitors, and inducers of human drug metabolizing enzymes: a systematic review. Drug Metab Rev. 2014; 46:86–95
- Fusar-Poli P, Crippa JA, Bhattacharyya S, et al. Distinct effects of D9-tetrahydro-cannabinoland cannabidiol on neural activation during emotional processing. Arch Gen Psychiat. 2009; 66:9–5
- Pelkonen O, Mäeenpäeä J, Taavitsainen P, et al. Inhibition and induction of human cytochrome P450 (CYP) enzymes. Xenobiotica. 1998; 28:1203–1253
- Linge R, Jiménez-Sánchez L, Campa L, et al. Cannabidiol induces rapid-acting antidepressant- effects and enhances cortical 5-HT/glutamate neurotransmission: role of 5-HT 1A receptors. Neuropharmacology. 2016; 103:16–26
What Are the Health Benefits of CBD Oil?
As more and more U.S. states legalize marijuana, a product known as CBD oil has surged in popularity among consumers. CBD refers to cannabidiol, a non-intoxicating extract from cannabis that does not have the psychoactive properties of tetrahydrocannabinol (THC). Un THC, CBD does not gets people “high.”
CBD oil contains CBD mixed with an inert carrier oil, such as coconut oil or hemp seed oil. The bottled oil, called a tincture, is sold in various concentrations. There are also CBD capsules, CBD gummies, and under-the-tongue CBD sprays. Depending on where you live, some brands contain trace amounts of THC.
CBD oil is believed by some to treat pain, reduce anxiety, and stimulate appetite in the same way that marijuana does. CBD has also shown promise in treating certain types of seizures.
In 2018, the U.S. Food and Drug Administration (FDA) approved Epidiolex, a CBD oral solution used for the treatment of certain rare forms of epilepsy in children under two.
Verywell / Brianna Gilmartin
The exact mechanism of action of CBD is unclear. Un THC, CBD has a relatively low affinity for cannabinoid receptors in the brain. These are the molecules to which THC binds to elicit its psychoactive effects.
Instead, CBD is thought to influence other receptors, including opioid receptors that regulate pain and glycine receptors involved in the regulation of the “feel-good” hormone serotonin.
Proponents claim that CBD oil can treat a wide variety of health problems, including:
- Chronic pain
- Drug addiction and withdrawal
- High blood pressure
- Muscle spasms
- Parkinson's disease
Some of these claims are better supported by research than others. Despite its growing popularity, CBD oil remains sorely under-researched. Here is just some of what the current evidence says:
CBD shows promise in the treatment of anxiety disorders, suggests a 2015 review of studies in the journal Neurotherapeutics. According to the investigators, CBD demonstrated potent anxiolytic (anxiety-relieving) effects in animal research, albeit with counterintuitive results.
In all but a few studies, lower doses of CBD (10 milligrams per kilogram or less) were better able to treat symptoms of anxiety. Higher doses (100 milligrams per kilogram or more) exhibited virtually no effect.
Part of this response could be explained by the way that CBD acts in the brain. In many cases, CBD works as an agonist, meaning that it triggers an opposite response when binding to a receptor. It is possible that low doses can elicit a positive agonist response, while high doses “overwhelm” the brain and trigger a compensatory effect to “fight” CBD's effects.
Among the few human trials evaluating CBD's anxiolytic effects was one published in the Brazilian Journal of Psychiatry in 2019.
For this study, 57 men were given either CBD oil or a placebo before a public-speaking event. Anxiety was evaluated using physiological measures (such as blood pressure, heart rate, etc.
) and a relatively reliable test for mood states known as the Visual Analog Mood Scale (VAMS).
According to the investigators, men provided 300 mg of CBD exhibited less anxiety than those given a placebo. Interestingly, those provided 100 mg or 600 mg of CBD oil did not.
CBD oil may offer benefit those with drug addiction, suggests a 2015 review of studies published in Substance Abuse.
In an analysis of 14 published studies (nine involving animals and five involving humans), scientists with the University of Montreal concluded that CBD “showed promise” in treating people with opioid, cocaine, or psychostimulant addiction.
However, the effect of CBD on each addiction type was often very different. With opioid addiction, for example, CBD showed little effect in minimizing withdrawal symptoms in the absence of THC. By contrast, CBD on its own appeared effective in minimizing drug-seeking behaviors in users of cocaine, methamphetamine, and other psychostimulant drugs.
There have also been suggestions that CBD may aid in the treatment of cannabis and nicotine addiction. Further research is needed.
Medical marijuana is frequently prescribed to people with intractable pain, including those with terminal cancer. There is some evidence that CBD contributes to this effect.
According to a 2012 study in the Journal of Experimental Medicine, rats injected with inflammatory chemicals in their hindfeet experienced less inflammation and neuropathic pain when treated with an oral dose and spinal injection of CBD.
Scientists believe that CNB reduces nerve pain by binding to glycine receptors in the brain that regulate the speed in which nerve signals pass between nerve cells.
Human studies evaluating the use of CBD in treating chronic pain are lacking. Those that do exist almost invariably include THC, making it difficult to isolate CBD's distinct effects.
CBD oil may reduce the risk of heart disease by alleviating hypertension (high blood pressure) in certain people, suggests a 2017 study in JCI Insight.
For this study, nine healthy men took either 600 milligrams (mg) of CBD or 600 mg of a placebo. According to the researcher, those treated with CBD had lower blood pressure before and after exposure to stressful stimuli (including exercise or extreme cold).
In addition, the stroke volume (the amount of blood remaining in the heart after a heartbeat) was significantly reduced, meaning that the heart was pumping more efficiently.
The findings suggest that CBD oil may be a suitable complementary therapy for people whose hypertension is complicated by stress and anxiety.
However, there is no evidence that CBD oil can treat hypertension on its own or prevent hypertension in people at risk. While stress is known to complicate high blood pressure, it cannot cause hypertension.
In June 2018, the FDA approved Epidiolex for the treatment of seizures associated with Dravet syndrome and Lennox-Gastaut syndrome in children two and under. Both are exceptionally rare genetic disorders causing lifelong catastrophic seizures that begin during the first year of life.
Outside of these two disorders, CBD's effectiveness in treating seizures is uncertain. Even with Epidiolex, it is uncertain whether the anti-seizure effects can be attributed to CBD or some other factor.
In fact, there is some evidence that CBD interacts with seizure medications, such as Onfi (clobazam), and “boosts” their concentration in the blood. This would not only make the drugs more effective but extend their half-lives as well. Further research is needed.
Clinical research has shown that CBD oil can trigger side effects – the severity and type of which can vary from one person to the next. Common symptoms include:
- Changes in appetite
- Changes in mood
- Dry mouth
CBD oil may also increase liver enzymes (a marker of liver inflammation). People with liver disease should use CBD oil with caution, ideally under the care of a doctor who can regularly check blood liver enzyme levels.
CBD oil should be avoided during pregnancy and breastfeeding. A 2018 study from the American Academy of Pediatrics warned women to avoid marijuana during pregnancy due to the potential risks to a baby's development. Although it is unclear how CBD contributes, CBD is known to able to pass through the placental barrier.
If you are thinking about using CBD oil to treat a health condition, be sure to speak with your healthcare provider to ensure that it is the right option for you.
Be advised that some CBD oils contain trace amounts of THC. As such, you should avoid driving or using heavy machinery when taking CBD oil, particularly when first starting treatment or using a new brand.
CBD oil can interact with certain medications, including some used to treat epilepsy. CBD inhibits an enzyme called cytochrome P450 (CYP450) which certain drugs use for metabolization. By interfering with CYP450, CBD may either increase the toxicity or decrease the effectiveness of these drugs.
The potential drug-drug interactions include:
- Anti-arrhythmia drugs quinidine
- Anticonvulsants Tegretol (carbamazepine) and Trileptal (oxcarbazepine)
- Antifungal drugs Nizoral (ketoconazole) and Vfend (voriconazole)
- Antipsychotic drugs Orap (pimozide)
- Atypical antidepressants Remeron (mirtazapine)
- Benzodiazepine sedatives Klonopin (clonazepam) and Halcion (triazolam)
- Immune-suppressive drugs Sandimmune (cyclosporine)
- Macrolide antibiotics clarithromycin and telithromycin
- Migraine medications Ergomar (ergotamine)
- Opioid painkillers Duragesic (fentanyl) and alfentanil
- Rifampin-based drugs used to treat tuberculosis
Many of these interactions are mild and require no adjustment to treatment. Others may require a drug substitution or the separation of doses by several hours.
To avoid interactions, advise your doctor about any drugs you are taking, whether they be prescription, over-the-counter, herbal, or recreational.
There are no guidelines for the appropriate use of CBD oil. CBD oil, also referred to as CBD tincture, is usually delivered sublingually (under the tongue). Most are sold in 30-milliliter (mL) bottles with a dropper cap.
There is no “correct” dose of CBD oil. Depending on who you speak to, the daily dose can range anywhere from 5 mg and 25 mg per day.
The tricky part, of course, is calculating the exact amount of CBD per milliliter of oil. After all, some tinctures have concentrations of 1,500 mg per 30 mL, while others will have 3,000 mg per mL (or more).
To determine the exact dose, remember that each drop equals 0.05 mL. This means that a 30-mL bottle of CBD oil will have roughly 600 drops. If the concentration of the tincture is 1,500 mg per mL, one drop would equal 2.5 mg (1,500 mg ÷ 600 drops = 2.5 mg).
To use CBD oil, place one or more drops under the tongue and let it sit there for 30 to 60 seconds without swallowing. Capsules and gummies are easier to dose, although they tend to be more costly. CBD sublingual sprays are used mainly for convenience.
Aficionados of CBD oil will tell you to buy full-spectrum oils over CBD isolates. Un isolates, which contain CBD only, full-spectrum oils contain a variety of compounds found naturally in the cannabis plant, including proteins, flavonoids, terpenes, and chlorophyll. Alternative practitioners believe these compounds offer health benefits, although there is no clear evidence of this.
Because CBD oils are largely unregulated, there is no guarantee that a product is either safe or effective.
According to a 2017 study in the Journal of the American Medical Association, only 30.95% of CBD products sold online were correctly labeled. Most contained less CBD than advertised, while 21.43% had significant amounts of THC.
Here are a few tips to help you find the best CBD oil:
- Buy American. Domestically produced CBD oil tends to be safer because of better growing and refining practices.
- Go organic. Brands certified organic by the U.S. Department of Agriculture (USDA) are less ly to expose you to pesticides and other harmful chemicals.
- Read the product label. Even if you choose a full-spectrum oil, don't assume that every ingredient on the product label is natural. There may be preservatives, flavorings, or thinning agents that you don't want or need.
If you don't recognize an ingredient, ask the dispenser what it is or check online.
Not necessarily. Although some people use the terms “CBD oil” and “hemp oil” synonymously, they may also be referring to hemp seed oil which is primarily used for cooking, food production, and skincare products.
CBD oil is made from leaves, stem, bud, and flower of the Cannabis indica or Cannabis sativa plant and contains less than 0.3% THC. Hemp oil is made from the seeds of Cannabis sativa and contains no TCH.