Tempol: Potential Health Benefits + Risks

Tunes for training: High-tempo music may make exercise easier and more beneficial

Tempol: Potential Health Benefits + Risks

With the start of the new year, gyms are at their busiest and many people are trying to establish a workout routine to improve their health.

Getting an edge by making exercise easier and more effective could be the difference between success and guiltily returning to the warm embrace of the couch.

What if doing something as simple as listening to a particular type of music could give you that edge?

A new study in Frontiers in Psychology is the first to show that listening to music at a higher tempo reduces the perceived effort involved in exercise and increases its benefits.

These effects were greater for endurance exercises, such as walking, than for high-intensity exercises, such as weightlifting.

The researchers hope that the findings could help people to increase and improve their exercise habits.

Many people listen to music while exercising and previous studies have documented some of the benefits. For instance, music can distract from fatigue and discomfort and increase participation in exercise.

However, “how” we experience music is highly subjective, with cultural factors and personal preferences influencing its effects on individuals.

Music is multifaceted with various aspects such as rhythm, lyrics and melody contributing to the experience.

Until now, researchers did not understand the specific properties of music that affect us during exercise, including which types of music are best suited to enhancing certain types of exercise. Understanding these specifics could help to unlock the full potential of music as an exercise enhancer.

The researchers set out to investigate the effect of the tempo of a piece of music on female volunteers performing either an endurance exercise (walking on a treadmill) or a high-intensity exercise (using a leg press).

The volunteers completed exercise sessions in silence, or while listening to pop music at different tempos. The researchers recorded a variety of parameters, including the volunteers' opinions about the effort required to complete the exercises and their heart rate while exercising, as a higher heart rate would mean that the exercise was more beneficial for physical fitness.

“We found that listening to high-tempo music while exercising resulted in the highest heart rate and lowest perceived exertion compared with not listening to music,” explained Professor Luca P. Ardigò of the University of Verona in Italy. “This means that the exercise seemed less effort, but it was more beneficial in terms of enhancing physical fitness.”

These effects were more noticeable in volunteers completing the endurance exercise sessions, compared with those performing high-intensity exercises, suggesting that people performing endurance activities such as walking or running may receive the greatest benefit from listening to high-tempo music.

The researchers hope that these results will provide a simple way to improve levels of physical activity. While the current study involved a small group of volunteer subjects, larger studies in the future will be needed to continue exploring the nuances of how music affects our training.

“In the current study, we investigated the effect of music tempo in exercise, but in the future we would also to study the effects of other music features such as genre, melody, or lyrics, on endurance and high intensity exercise,” said Ardigò.

So, you could try playing fast-tempo music next time you hit the gym for a turbo-charged workout. Otherwise, it might at least get your foot tapping while you sit on the couch and eat chocolate.

Story Source:

Materials provided by Frontiers. Original written by Conn Hastings. Note: Content may be edited for style and length.

Source: https://www.sciencedaily.com/releases/2020/02/200202105147.htm

Home Care

Tempol: Potential Health Benefits + Risks

Home Caredev2019-11-11T17:14:03+00:00 Home care providers are on the front line with families struggling to find care answers for their declining senior loved ones. Their challenges include unexpected acuity changes, productivity of staff, and tech-savvy families who want to stay connected to their loved ones.

CarePredict provides timely visibility and insights enabling proactive action to address increasing care needs, to improve staff productivity and the opportunity to increase revenue the need for higher levels of care. Caring for seniors living at home is a rewarding, but sometimes frustrating, job.

With full and part-time home care shared between several caregivers, it is almost impossible to notice subtle changes in individual client’s daily ADL patterns that could lead to significant health issues.

CarePredict watches over those daily patterns and identifies changes that could indicate progression of memory issues, chronic conditions, urinary tract infections, fall risk and mental health risk. Having new people become part of a senior’s daily life is stressful for all involved.

Loved ones worry that the right choice has been made. They wonder if their loved one’s health is being closely monitored or if their loved one needs more help. Home care providers can share reassuring information, generated by CarePredict, with the families of seniors and their loved ones.

Tempo detects changes that may signal the onset of serious health problems, urinary tract infections, and alerts the home care provider for early intervention before the senior needs to be hospitalized.

Tempo helps home care providers prioritize staff time in areas where senior clients need the most care.

Tempo displays near real time location of seniors in their homes on web and mobile apps. In areas of the home that families have determined might be dangerous for the senior, Tempo sends multi-mode (or geofence) alerts when the senior approaches a prohibited area.

For seniors that may not be ready for home care, Tempo can provide a level of monitoring to reassure families. For seniors receiving home care who cannot or do not want to move to assisted living, Tempo can supplement home care services by providing 24/7 monitoring.

Home care providers can choose to share reassuring information with families, giving them valuable health insight into the lives of their loved ones.

Tempo provides objective data to illustrate to families the need to increase level of services provided to home care clients.

CarePredict provides in-depth productivity insights, so you can allocate more staff resources.

Know the exact location of individual staff when they are on-site, via the web portal or smartphone app, and get insight into their movement patterns within the home during their shifts.

Find out how much time staff spends with individual clients, and better understand how that changes over weeks or months.

Gathering health insights enables you to better understand the specific level of care required for each client. CarePredict's objective data also helps support sensitive discussions with loved ones, such as when to increase staff time spent with the client or when to transition them to assisted living communities.

Source: https://www.carepredict.com/home-care/

Tempol: Potential Health Benefits + Risks

Researchers at Temple University’s College of Public Health expect to receive $1.28 million to look at potential links between PFAS-contaminated drinking water and cancer as part of a national, federally funded health study. 

PFAS, a toxic class of chemicals used in firefighting foam at former military bases in Bucks and Montgomery counties, have been an ongoing concern in the Philadelphia region, as residents demand answers about potential health effects and regulators grapple with how and whether to set legally binding standards.

The study, announced Monday by the Centers for Disease Control and Prevention and the Agency for Toxic Substances and Disease Registry, will involve seven sites across the country, including Bucks and Montgomery counties in Pennsylvania and Gloucester County in New Jersey. 

However, the national study will not examine possible links to cancer, a decision that, when announced, frustrated many area residents who have outstanding questions whether cancers they were diagnosed with can be linked to PFAS.

The Temple researchers, who are assisting the Pennsylvania Department of Health with data collection, plan to use some of the data gathered for the national study for two additional studies that will look at PFAS cancer associations locally.

“The goal would be to help really provide some answers to the community,” said Resa M. Jones, chair of epidemiology and biostatistics at Temple’s College of Public Health — “both the local community of Bucks and Montgomery counties, but also to the research community.”

The $1.28 million would be part of the anticipated $5 million the state expects to receive over five years for the national study. Part of the research for that study will involve blood testing of more than 1,000 residents of Bucks and Montgomery counties who were exposed to PFAS, looking for links to health conditions ranging from high cholesterol to thyroid disease.

But the other part of that study will involve reconstructing a history of people’s exposure to PFAS. That’s where the Temple researchers come in.

They will work with the Department of Health and a North Carolina-based firm, RTI, to reconstruct levels of PFAS exposure in Bucks and Montgomery Counties over time, current concentrations of the chemicals and their known half-lives, or the time it takes for them to decrease by half. That model is a key part of the national study and will be done by the six other communities across the country.

In their extension study, the Temple researchers will take that reconstruction and create historical models in 11 other counties surrounding Bucks and Montgomery.

“We’re being very purposeful in expanding beyond Bucks and Montgomery counties to include the other 11 counties surrounding the area,” said Jones, “so that we have more variability in PFAS water contamination exposure.”

The team will then look at cancer-registry data for those 13 counties and, using statistical models, determine if higher concentrations of PFAS in drinking water are associated with higher rates of particular cancers.

“By being able to link and partner with the Department of Health and link cancer-registry data and then select population-based controls, we’re able to leverage existing data to answer some of these really important research questions,” Jones said.

A second arm of the research will target people who were part of core CDC research in Bucks and Montgomery Counties who were diagnosed with thyroid and kidney cancer, following up with them to expand and create a family network.  

But there are challenges in doing this kind of research. 

“It’s hard to do,” said Kyle Steenland, professor of epidemiology at Emory University. “You need a cohort you can follow over time, and you need good estimates of historical exposure, and that takes a long time to develop, if it’s possible.”

Steenland was one of three epidemiologists on the C8 Science Panel, which was created as part of a settlement agreement following a lawsuit against DuPont by communities in West Virginia’s Mid-Ohio Valley.

The panel spent eight years studying 32,000 people in the Mid-Ohio Valley who had been exposed to PFOA, using data about how much PFOA had been released into the environment over time, information the researchers had access to. 

Through that data, the panel wrote, “We conclude that there is a probable link between exposure to C8 (also known as PFOA) and testicular cancer and kidney cancer but not any of the other cancers that were considered.”

Steenland noted, however, that was only one PFAS chemical of nearly 5,000, and that in spite of the conclusion “the evidence base [for cancer] is weak.”

The Temple researchers plan to look at 14 PFAS chemicals, and through statistical models they hope to shed some light on which types of PFAS are most strongly associated with cancer.

Jones said she knows they won’t be able to get an actual PFAS exposure for every cancer case.

“It’s an estimate,” she said.

Still, she said, the scientific inquiry is worthwhile.

“Because this kind of thing hasn’t been done before, it will help us advance what is known in terms of linkages between PFAS water contamination and cancer incidence,” Jones said.

For the CDC’s part, it, along with the Agency for Toxic Substances and Disease Registry, is considering other ways to investigate the relationship between PFAS exposure and cancer, including conducting an analysis of “previously collected data.” 

But in an email, the CDC said that “planning for this analysis is still in the early stages.”

Source: https://whyy.org/articles/temple-researchers-will-look-at-link-between-pfas-and-cancer/

Tempol: Potential Health Benefits + Risks

Tempol: Potential Health Benefits + Risks

Tempol is a synthetic compound similar to the antioxidant enzyme superoxide dismutase. Proponents claim that it can be used to lower stress, prevent oxidative damage, and improve heart disease and diabetes. Read more to find about this chemical antioxidant.

What Is Tempol?

Tempol, also known as 4-hydroxy-TEMPO, is a stable, synthetic compound that mimics the superoxide dismutase enzyme. This enzyme helps to increase the rate of breakdown of the superoxide radical into oxygen or hydrogen peroxide [1].

Tempol may protect against radiation and is used as a chemical antioxidant [2].

Tempol restores the effects of the cytokine TNF-alpha, which is involved in immune function and acute inflammation [3].

In rats, Tempol decreased blood pressure and the activity of the fight-or-flight (sympathetic) nervous system [2].

Tempol is very similar to the antioxidant Tempo but is often preferred due to its lower price [4].

It has the potential to improve diseases caused by oxidative stress, particularly diabetes and its complications such as high blood pressure, coronary heart disease, and kidney damage. Tempol acts in a similar way to the superoxide dismutase: it prevents the production of free radicals through oxidation of iron [5].


  • Antioxidant activity
  • May protect from radiation
  • Few adverse effects reported


  • Insufficient evidence for all potential benefits
  • Most studies have been carried out in animals
  • May cause toxicity, especially if repeatedly used

Insufficient Evidence

The following purported benefits are only supported by limited, low-quality clinical studies and animal research. There is insufficient evidence to support the use of Tempol for any of the below-listed uses. Remember to speak with a doctor before taking Tempol never use it as a replacement for approved medical therapies.

1) Reducing Oxidative Damage

Free radicals are molecules with unpaired electrons. These molecules are highly reactive and can damage the tissues by chemically reacting with cell components [6].

The buildup of free radicals is referred to as “oxidative stress” and contributes to the development and progression of many diseases, including neurodegenerative diseases, cancer, chronic fatigue syndrome, inflammatory diseases, blood vessel disorders, and high cholesterol. Importantly, it may contribute to kidney failure, heart disease, obesity, and stroke by raising blood pressure [6, 7].

As previously mentioned, Tempol prevents the production of free radicals through the oxidation of iron [6].

In a clinical trial on 18 healthy men, Tempol broke down oxygen-centered free radicals such as superoxide. This reaction formed the molecule nitroxide, which can be measured to assess oxidative damage [8].

By overproducing free radicals, nitroglycerin prevents the fight-or-flight nerve system from blocking blood vessel tightening in working muscles. This leads to an insufficient blood supply during physical exercise. In rats, Tempol broke down the excess of free radicals and prevented this effect [9].

In mice prone to high blood cholesterol, Tempol prevented artery clogging by reducing LDL oxidation. It did so by blocking the oxidant enzyme Nox2 [10].

In a study in pigs, Tempol had antioxidant activity but it was insufficient to protect the kidneys from the oxidative damage caused by insufficient blood flow resulting from blood vessel narrowing (artery stenosis) [11].

However, Tempol (and superoxide dismutase) can drive oxidation in some cases. In a clinical trial on 30 people with HIV, Tempol increased the toxicity of the antibiotic sulfamethoxazole to the tissues by promoting its oxidation in the same way as the superoxide dismutase enzyme does [12].

Two small clinical trials (with opposite results) and some animal research cannot be considered conclusive evidence that Tempol prevents health conditions caused by oxidative stress. Further clinical research is needed to shed some light on this potential health benefit.

2) Protecting Against Radiation

Due to its antioxidant activity, Tempol can act as a radioreceptor- a substance that protects cells of surrounding normal tissue from radiation damage. In a clinical trial on 11 cancer patients, topical Tempol applied on the scalp reduced hair loss due to radiation [13].

A single, small clinical trial is clearly insufficient to support this use of Tempol. Larger, more robust clinical trials are needed to validate this preliminary result.

Animal and Cell Research (Lack of Evidence)

No clinical evidence supports the use of Tempol for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies should not be interpreted as supportive of any health benefit.


GPR120 is a type of G protein-coupled receptor with anti-inflammatory and insulin-sensitizing effects. In obese rats, Tempol reduced oxidative damage and insulin resistance by restoring the activity of this receptor [14, 15].

In rats infused high amounts of sugar, Tempol reduced the damage to the insulin-producing pancreatic cells (beta-cells) by breaking down the superoxide free radical, possibly preventing the onset of diabetes [16].

In diabetic mice, an antioxidant acting in a similar way to Tempol (IAC) lowered blood sugar by protecting the beta-cells [17].

Kidney damage (diabetic nephropathy) is a progressive kidney disease occurring as a result of oxidative stress in diabetics. Tempol helped slow down the progression of this disease in diabetic mice and rats by reducing oxidative stress [18, 19].


In mice, Tempol reduced diet-induced obesity by altering the gut microbiome (it reduced some Lactobacillus strains). This changed their metabolism towards reduced energy availability and increased sugar and fat breakdown by blocking the farnesoid X receptor [20, 21].

High Blood Pressure

Patients with hypertension (high blood pressure) tend to have kidneys with a decreased ability to excrete sodium.

The neurotransmitter dopamine promotes sodium excretion and reduces its uptake by activating its D1 receptors in the kidneys Dopamine D1 Receptors. Tempol improved D1 function in rats. By doing so, it may help with sodium balance and thus prevent high blood pressure [15].

Protecting the Nerves and Brain

Tempol may reduce brain and nerve cell death by decreasing oxidative stress, possibly preventing neurological conditions such as eye degeneration, stroke, and Parkinson’s disease [5].

Kidney Function

When the blood flow to the kidneys is restored after a period of low supply (ischemia-reperfusion), oxidative stress damages the kidneys and may cause their failure. In rats at the early stages of ischemia-reperfusion injury, Tempol reduced markers of kidney damage (urea, creatinine, sodium, gammaGT, aspartate aminotransferase, and NAG) [22, 23].

Potential Risks

Keep in mind that the safety profile of Tempol is relatively unknown, given the lack of well-designed clinical studies. The list of side effects below is not a definite one and you should consult your doctor about other potential side effects your health condition and possible drug or supplement interactions.

Tempol is not irritating to the skin but can be corrosive to the eyes [24].

Although single doses have low to moderate toxicity, Tempol can be toxic when repeatedly used. However, Tempol risk and exposure are overall very low [24].

Source: https://selfhacked.com/blog/tempol/

Health Effects of Cigarette Smoking

Tempol: Potential Health Benefits + Risks

Cigarette smoking harms nearly every organ of the body, causes many diseases, and reduces the health of smokers in general.1,2

Quitting smoking lowers your risk for smoking-related diseases and can add years to your life.1,2

Cigarette smoking is the leading preventable cause of death in the United States.1

  • Cigarette smoking causes more than 480,000 deaths each year in the United States. This is nearly one in five deaths.1,2,3
  • Smoking causes more deaths each year than the following causes combined:4
    • Human immunodeficiency virus (HIV)
    • Illegal drug use
    • Alcohol use
    • Motor vehicle injuries
    • Firearm-related incidents
  • More than 10 times as many U.S. citizens have died prematurely from cigarette smoking than have died in all the wars fought by the United States.1
  • Smoking causes about 90% (or 9 10) of all lung cancer deaths.1,2 More women die from lung cancer each year than from breast cancer.5
  • Smoking causes about 80% (or 8 10) of all deaths from chronic obstructive pulmonary disease (COPD).1
  • Cigarette smoking increases risk for death from all causes in men and women.1
  • The risk of dying from cigarette smoking has increased over the last 50 years in the U.S.1

Smokers are more ly than nonsmokers to develop heart disease, stroke, and lung cancer.1

  • Estimates show smoking increases the risk:
    • For coronary heart disease by 2 to 4 times1,6
    • For stroke by 2 to 4 times1
    • Of men developing lung cancer by 25 times1
    • Of women developing lung cancer by 25.7 times1
  • Smoking causes diminished overall health, increased absenteeism from work, and increased health care utilization and cost.1

Smokers are at greater risk for diseases that affect the heart and blood vessels (cardiovascular disease).1,2

  • Smoking causes stroke and coronary heart disease, which are among the leading causes of death in the United States.1,3
  • Even people who smoke fewer than five cigarettes a day can have early signs of cardiovascular disease.1
  • Smoking damages blood vessels and can make them thicken and grow narrower. This makes your heart beat faster and your blood pressure go up. Clots can also form.1,2
  • A stroke occurs when:
    • A clot blocks the blood flow to part of your brain;
    • A blood vessel in or around your brain bursts.1,2
  • Blockages caused by smoking can also reduce blood flow to your legs and skin.1,2

Smoking can cause lung disease by damaging your airways and the small air sacs (alveoli) found in your lungs.1,2

  • Lung diseases caused by smoking include COPD, which includes emphysema and chronic bronchitis.1,2
  • Cigarette smoking causes most cases of lung cancer.1,2
  • If you have asthma, tobacco smoke can trigger an attack or make an attack worse.1,2
  • Smokers are 12 to 13 times more ly to die from COPD than nonsmokers.1

Smoking can cause cancer almost anywhere in your body:1,2

  • Bladder
  • Blood (acute myeloid leukemia)
  • Cervix
  • Colon and rectum (colorectal)
  • Esophagus
  • Kidney and ureter
  • Larynx
  • Liver
  • Oropharynx (includes parts of the throat, tongue, soft palate, and the tonsils)
  • Pancreas
  • Stomach
  • Trachea, bronchus, and lung

Smoking also increases the risk of dying from cancer and other diseases in cancer patients and survivors.1

If nobody smoked, one of every three cancer deaths in the United States would not happen.1,2

Smoking harms nearly every organ of the body and affects a person’s overall health.1,2

  • Smoking can make it harder for a woman to become pregnant. It can also affect her baby’s health before and after birth. Smoking increases risks for:1,2,5
    • Preterm (early) delivery
    • Stillbirth (death of the baby before birth)
    • Low birth weight
    • Sudden infant death syndrome (known as SIDS or crib death)
    • Ectopic pregnancy
    • Orofacial clefts in infants
  • Smoking can also affect men’s sperm, which can reduce fertility and also increase risks for birth defects and miscarriage.2
  • Smoking can affect bone health.1,5
    • Women past childbearing years who smoke have weaker bones than women who never smoked. They are also at greater risk for broken bones.
  • Smoking affects the health of your teeth and gums and can cause tooth loss.1
  • Smoking can increase your risk for cataracts (clouding of the eye’s lens that makes it hard for you to see). It can also cause age-related macular degeneration (AMD). AMD is damage to a small spot near the center of the retina, the part of the eye needed for central vision.1
  • Smoking is a cause of type 2 diabetes mellitus and can make it harder to control. The risk of developing diabetes is 30–40% higher for active smokers than nonsmokers.1,2
  • Smoking causes general adverse effects on the body, including inflammation and decreased immune function.1
  • Smoking is a cause of rheumatoid arthritis.1
  • Quitting smoking cuts cardiovascular risks. Just 1 year after quitting smoking, your risk for a heart attack drops sharply.2
  • Within 2 to 5 years after quitting smoking, your risk for stroke may reduce to about that of a nonsmoker’s.2
  • If you quit smoking, your risks for cancers of the mouth, throat, esophagus, and bladder drop by half within 5 years.2
  • Ten years after you quit smoking, your risk for dying from lung cancer drops by half.2
  1. U.S. Department of Health and Human Services.The Health Consequences of Smoking—50 Years of Progress: A Report of the Surgeon General. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014 [accessed 2017 Apr 20].
  2. U.S. Department of Health and Human Services. How Tobacco Smoke Causes Disease: What It Means to You. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2010 [accessed 2017 Apr 20].
  3. Centers for Disease Control and Prevention. QuickStats: Number of Deaths from 10 Leading Causes—National Vital Statistics System, United States, 2010. Morbidity and Mortality Weekly Report 2013:62(08);155. [accessed 2017 Apr 20].
  4. Mokdad AH, Marks JS, Stroup DF, Gerberding JL. Actual Causes of Death in the United States. JAMA: Journal of the American Medical Association 2004;291(10):1238–45 [cited 2017 Apr 20].
  5. U.S. Department of Health and Human Services. Women and Smoking: A Report of the Surgeon General. Rockville (MD): U.S. Department of Health and Human Services, Public Health Service, Office of the Surgeon General, 2001 [accessed 2017 Apr 20].
  6. U.S. Department of Health and Human Services. Reducing the Health Consequences of Smoking: 25 Years of Progress. A Report of the Surgeon Generalexternal icon. Rockville (MD): U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 1989 [accessed 2017 Apr 20].

Centers for Disease Control and PreventionNational Center for Chronic Disease Prevention and Health PromotionOffice on Smoking and Health

E-mail: tobaccoinfo@cdc.gov

Phone: 1-800-CDC-INFO

Media Inquiries: Contact CDC’s Office on Smoking and Health press line at 770-488-5493.


Source: https://www.cdc.gov/tobacco/data_statistics/fact_sheets/health_effects/effects_cig_smoking/index.htm

Ear Tubes

Tempol: Potential Health Benefits + Risks

Ear tubes are recommended when an individual suffers repeated ear infections of the middle ear, loses hearing due to fluid in the middle ear, or is off-balance due to fluid in the middle ear.

When in place, ear tubes are effective at holding open an incision in the eardrum, allowing drainage of the affected middle ears and preventing the accumulation of fluid and infection in the middle ear space.

This helps reduce the risk for ear infection in the future, restores hearing, improves balance, resolves speech problems, and improves sleep and behavior issues brought on by chronic ear infections.

While an occasional viral ear infection will resolve without treatment and bacterial infections are often treated and cured with antibiotics, ear infections aren’t always easy to overcome.

When the infections continue to arise time and again, more aggressive action must be taken in order to prevent an array of potential health and hearing problems.

In many cases, that action is placing ear tubes in the ears of the affected individual.

Why Consider Ear Tubes?

Reasons a child or adult may need ear tubes include the following:

  • Frequent middle ear infection. Beneath the eardrum, there is an open area (the middle ear) that is home to tiny vibrating ear bones. When a bacterial or viral infection settles in there, the result is sudden inflammation and pain.
  • Hearing loss related to middle ear fluid. Frequent middle ear infections, allergies and other conditions can cause fluid to form and stay in the middle ear for a prolonged period. Eventually, this fluid can result in hearing loss.
  • Dizziness related to middle ear fluid. Fluid in the ear can cause dizziness and is a readily treatable cause of dizziness. In young children, this dizziness may appear as lack of coordination.
  • Tinnitus related to middle ear fluid. Fluid in the ear can cause tinnitus, or extra sounds in the ears. This can sound your pulse, or ringing or a seashell. This is a treatable cause of tinnitus.

What to Expect with Ear Tube Placement

Prior to receiving ear tubes, the affected individual undergoes tests to ensure the tubes will effectively treat his or her symptoms.

Should the individual no longer respond properly to antibiotics or be at risk for hearing loss due to chronic ear infections, ear tubes are a good option.

Tubes are very efficient at draining fluid from the middle ear, and may be the only way to completely remove fluid that has been present in the middle ear for many months.

Installing ear tubes is a relatively simple procedure that normally takes less than half an hour. During the procedure, a small incision is made in the eardrum by the surgeon with a tiny scalpel. The surgeon then locates and removes any fluid residing in the inner ear using a suction device. Once the fluid is removed, the ear tube is inserted into the hole made by the surgeon.

While the ear tube will stay in the patient’s ear for at least several months, the patient will typically regain any lost hearing due to fluid build-up immediately and can return to activities of daily living within 24 hours.

Over the course of time, the ear tube normally falls out without assistance and the surgical hole made by the surgeon closes on its own. Should the ear tubes fall out earlier than that, new tubes may need to be installed to ensure the treatment provides long-term benefits.

In extreme cases of frequent fluid in the middle ear, the otolaryngologist may additionally encourage the removal of adenoid tissue if it is enlarged, as this can increase the success rate of ear tubes.

Why Temple Health for Ear Tubes?

In the event an individual’s recurrent ear infection causes significant speech or hearing issues, the multidisciplinary team at Temple Head & Neck Institute is ready to help.

Leading the region and nation in ear tubes and other associated services, the specialists at the Temple Head & Neck Institute give patients access to the most advanced diagnostic and therapeutic methods as recommended by current research.

Temple Health’s multidisciplinary team of specialists collaborates to manage ear infections and any potential hearing loss that accompanies it. Because of our understanding of the potential life-long problems associated with these issues, our team provides a tailored approach to treatment for each patient.

Ready for an Appointment?

Find a doctor near you, request an appointment, or call 800-TEMPLE-MED (800-836-7536) today.

Source: https://www.templehealth.org/services/treatments/ear-tubes

Tempol (acetaminophen) Safety Alerts, Recalls & Warnings – Drugs.com

Tempol: Potential Health Benefits + Risks

The FDA Alert(s) below may be specifically about Tempol or relate to a group or class of drugs which include Tempol (acetaminophen).

MedWatch Safety Alerts are distributed by the FDA and published by Drugs.com. Following is a list of possible medication recalls, market withdrawals, alerts and warnings. For the latest FDA MedWatch alerts, go here.

Acetaminophen Tablets by Medline Industries: Recall – Mislabeling with Incorrect Strength

Oct 15, 2015

Audience: Pharmacy, Consumer

ISSUE: On October 9, 2015, Medline Industries, Inc. announced that it will initiate a voluntary nationwide recall of lot # 45810 of Acetaminophen tablets, 500mg, uncoated compressed tablets to the consumer level.

The Acetaminophen 500mg, Tab 100/BT (OTC20101) has been found to be mislabeled displaying “Acetaminophen 325mg” (OTC10101) instead of “Acetaminophen 500mg”. The Acetaminophen tablets, 500mg is incorrectly labeled as 325 mg tablets. This error is not easily identifiable by the user or prescriber.

If the product is taken at the maximum labeled dose, every four hours, five doses a day, or with other medications containing acetaminophen, it may lead to liver toxicity or liver failure. See the firm Press Release for further details.

BACKGROUND: Acetaminophen tablets is an over the counter (OTC) oral medication used to temporarily relieve minor aches and pains due to minor pain of arthritis, muscular aches, back aches, headaches, toothaches, the common cold, premenstrual and menstrual cramps, and reduces fever. This item is packaged as 100 tablets per bottle, Medline Item Number: OTC20101, NDC#: 53329-641-30. The recalled Acetaminophen 500mg, Tab 100/BT (OTC20101) includes lot # 45810 with expiration date May 2018. This lot was distributed nationwide from June 12, 2015 through September 18, 2015.

RECOMMENDATION: Medline Industries, Inc. notified its distributors, consumers and/or retailer customers by First Class Mail on September 25th, 2015 and is arranging for return and credit of all recalled products. Consumers, distributors, and/or retailers that have product which is being recalled should stop using and return to Medline Industries, Inc.

Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

[10/09/2015 – Press Release – Medline Industries]

Prescription and Over-the-Counter (OTC) Pain Medicines: Drug Safety Communication – FDA Review of Possible Risks of Pain Medicine Use During Pregnancy

Jan 9, 2015

Audience: OBGYN, Consumer

[Posted 01/09/2015]

ISSUE:  FDA is aware of and understands the concerns arising from recent reports questioning the safety of prescription and over-the-counter (OTC) pain medicines when used during pregnancy.

As a result, FDA evaluated research studies published in the medical literature and determined they are too limited to make any recommendations these studies at this time. Because of this uncertainty, the use of pain medicines during pregnancy should be carefully considered.

FDA urges pregnant women to always discuss all medicines with their health care professionals before using them.

Severe and persistent pain that is not effectively treated during pregnancy can result in depression, anxiety, and high blood pressure in the mother.

Medicines including nonsteroidal anti-inflammatory drugs (NSAIDs), opioids, and acetaminophen can help treat severe and persistent pain.

However, it is important to carefully weigh the benefits and risks of using prescription and OTC pain medicines during pregnancy. 

BACKGROUND: The published studies FDA reviewed reported on the potential risks associated with the following three types of pain medicines used during pregnancy. See the FDA Drug Safety Communication Data Summary section for more information about these studies.

RECOMMENDATION: Healthcare professionals should talk with each patient about the benefits and risks of analgesic use during pregnancy, which may differ among patients and by treatment indication. Continue to follow the existing recommendations in current drug labels regarding the use of analgesics during pregnancy.

Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

[01/09/2015 – Drug Safety Communication – FDA]

Acetaminophen Prescription Combination Drug Products with more than 325 mg: FDA Statement – Recommendation to Discontinue Prescribing and Dispensing

Jan 14, 2014

Audience: Consumer, Dentistry, Emergency Medicine, Internal Medicine, Pharmacy, Pain Management, Surgery

ISSUE: FDA is recommending health care professionals discontinue prescribing and dispensing prescription combination drug products that contain more than 325 milligrams (mg) of acetaminophen per tablet, capsule or other dosage unit.

There are no available data to show that taking more than 325 mg of acetaminophen per dosage unit provides additional benefit that outweighs the added risks for liver injury.

Further, limiting the amount of acetaminophen per dosage unit will reduce the risk of severe liver injury from inadvertent acetaminophen overdose, which can lead to liver failure, liver transplant, and death.  

Cases of severe liver injury with acetaminophen have occurred in patients who:

• took more than the prescribed dose of an acetaminophen-containing product in a 24-hour period; • took more than one acetaminophen-containing product at the same time; or

• drank alcohol while taking acetaminophen products.

BACKGROUND: In January 2011 FDA asked manufacturers of prescription combination drug products containing acetaminophen to limit the amount of acetaminophen to no more than 325 mg in each tablet or capsule by January 14, 2014.

 FDA requested this action to protect consumers from the risk of severe liver damage which can result from taking too much acetaminophen.

This category of prescription drugs combines acetaminophen with another ingredient intended to treat pain (most often an opioid), and these products are commonly prescribed to consumers for pain, such as pain from acute injuries, post-operative pain, or pain following dental procedures.

Acetaminophen is also widely used as an over-the-counter (OTC) pain and fever medication, and is often combined with other ingredients, such as cough and cold ingredients.

 FDA will address OTC acetaminophen products in another regulatory action.

Many consumers are often unaware that many products (both prescription and OTC) contain acetaminophen, making it easy to accidentally take too much.

More than half of manufacturers have voluntarily complied with the FDA request.

However, some prescription combination drug products containing more than 325 mg of acetaminophen per dosage unit remain available.

In the near future FDA intends to institute proceedings to withdraw approval of prescription combination drug products containing more than 325 mg of acetaminophen per dosage unit that remain on the market.

RECOMMENDATION: FDA recommends that health care providers consider prescribing combination drug products that contain 325 mg or less of acetaminophen.

 FDA also recommends that when a pharmacist receives a prescription for a combination product with more than 325 mg of acetaminophen per dosage unit that they contact the prescriber to discuss a product with a lower dose of acetaminophen. A two tablet or two capsule dose may still be prescribed, if appropriate.

In that case, the total dose of acetaminophen would be 650 mg (the amount in two 325 mg dosage units). When making individual dosing determinations, health care providers should always consider the amounts of both the acetaminophen and the opioid components in the prescription combination drug product.

Health care providers and pharmacists who have further questions are encouraged to contact the Division of Drug Information at 888.INFO.FDA (888-463-6332) or druginfo@fda.hhs.gov.

Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

[01/14/2014 –  FDA Statement – FDA]
[Acetaminophen Information – FDA]

Perrigo Acetaminophen Infant Suspension Liquid: Recall – Potential Defect with Co-packaged Oral Syringe

Nov 2, 2013

Audience: Consumer, Patient, Pediatrics, Pharmacy, Health Professional

ISSUE: The Perrigo Company announced that it has initiated a voluntary, nationwide product recall to the retail level of 18 batches of its acetaminophen infant suspension liquid, 160 mg/5 mL, sold in 2 oz. and 4 oz. bottles with syringes in a box under store brand products including Babies R Us, Care One and more  (refer to the Firm Press Release for full list of affected brand names and products).

The recall is being initiated because of the remote potential that a small number of packages might contain an oral dosing syringe without dose markings. Using an oral syringe without dose markings can result in inaccurate dosing, especially in infants who could mistakenly get too high a dose.

BACKGROUND:  This over the counter product is indicated for the relief of fever and minor aches and pains and can be used in infants, children and adults. These recalled products are sold by distributors nationwide and distributed through retail stores.

RECOMMENDATION: If the oral dosing device contained in the package has dose markings (for 1.25 mL, 2.5 mL, 3.75 mL, and 5 mL), no action is required, and the consumer can continue to use the product consistent with the label instructions.

If the package contains an oral dosing device that does not have dose markings, the consumer should not use the product and should call Perrigo’s Consumer Affairs Department, toll free, 1-800-719-9260.

Consumers should contact their physician or healthcare provider if they have any questions, or if they or their children experience any problem that could possibly be related to this drug product.

Healthcare professionals and patients are encouraged to report adverse events or side effects related to the use of these products to the FDA's MedWatch Safety Information and Adverse Event Reporting Program:

Complete and submit the report Online: www.accessdata.fda.gov/scripts/medwatch/index.cfm

Source: https://www.drugs.com/fda-alerts/11-2955.html