- Anabolicum (LGD-4033)
- The History Of LGD-4033 And What It Is
- What Do The Studies Say?
- Why Is LGD-4033 More Popular In Medical Groups?
- How Can This SARM Help Bodybuilders Specifically?
- What Are The Side Effects Of LGD-4033?
- What Are The Doses Of Ligandrol And When Do You See Results?
- How To Get The Most LGD-4033
- Where Can I buy Ligandrol?
- Does Ligandrol (LGD 4033) Work? There Is Promise in the Research
- What Actually Is Ligandrol?
- How Much Research Is There?
- Does Ligandrol Increase Testosterone?
- Does Ligandrol Promote Fat Loss?
- Does Ligandrol Promote Muscle Growth?
- If You’re Using It Anyway…
- How Long Does It Take To “Kick In”?
- How Long Does It Stay In Your System?
- Is Ligandrol Safe? Are There Side Effects?
- Conclusion: What Should We Think About Ligandrol?
- A Complete Guide to Ligandrol (LGD-4033) -Updated August 2019-
- HOW DOES LIGANDROL HELP BODYBUILDERS?
- Why is LGD-4033 BETTER THAN STEROIDS?
- WHAT ARE THE POSSIBLE SIDE EFFECTS OF TAKING LGD 4033?
- WHAT IS THE MOST EFFECTIVE DOSE OF LIGANDROL?
- CAN I STACK LIGANDROL WITH OTHER SUPPLEMENTS?
- DOES LIGANDROL PROMOTE WEIGHT LOSS?
- WHAT DO PEOPLE SAY ABOUT LIGANDROL?
- WHERE CAN I GET LGD 4033?
- A Better Body in a Pill? Experts Urge Caution on SARMs
- Ligandrol LGD-4033: A Safer Alternative for Anabolic Steroids? – Providence Hospital
- History of Ligandrol
- Ligandrol Today…
- Ligandrol Mechanism of Action
- LGD-4033 and Bodybuilding
- Ligandrol Half-Life, Dosage and Cycle
- Stacking Ligandrol
- #1.Prevents Muscle Wasting
- #2.Prevents Cachexia
- #3.Preventing and Healing Osteoporosis and Bone Fractures
- #4. Mood Enhancement
- #5.Potential Male Contraception
- Pills, Powder or Liquid: Which is Best?
- Any Side Effects when Using LGD-4033?
- Finding Pure Ligandrol for Sale
- How to Buy Ligandrol LGD-4033
- Closing Thoughts
Though SARMs had been primarily researched and used to address osteoporosis, chronic diseases, and muscle loss, their use has expanded to weight lifters and those seeking a safer alternative to steroids.
Anabolic steroids have run rampant in the bodybuilding world for years, and many are aware of all the dangers their usage come with. Selective androgen receptor modulators are far more selective in their action within the human body, which is advantageous for those ingesting them because they do not harm organs as collateral damage.
Two SARM options frequently mentioned in the same breath are LGD-4033 and MK-2866. The reason these two are often paired together is they are known as the most potent oral SARMs available. With ardent users claiming LGD-4033 is the strongest. To determine its effects, it is vital to delve deeper into what LGD-4033 is exactly and how it helps.
The History Of LGD-4033 And What It Is
Also known as ligandrol/anabolicum, LGD-4033 was developed by the pharmaceutical Ligand (hence the name), with the goal in mind to promote healing properties in the body. This was to come in the form of limiting ‘wasting conditions’. As well as stimulating positive activity in bones and muscles.
The exclusivity of having an effect on certain areas is the primary reason it is sought out in lieu of anabolic steroids.
Steroids help in building muscle, but have side effects far more drastic than those currently recorded by SARMs.
Some of the issues that arise from anabolic steroids include changes in behavior, or ‘roid rage,’ an enlarged heart, and detrimental activity in the prostate gland and testes.
If this is enough to scare you, you are not alone, which is why an orally available solution ligandrol has gained so much traction.
The difference between LGD-4033 and steroids is that the latter disrupts all tissue, whereas anabolicum does not.
This is beneficial because it narrows down the potential side effects and allows users to better channel what areas of their body are being affected.
What Do The Studies Say?
Selective androgen receptor modulators sound great in theory, but feedback is where the impact of LGD-4033 is seen. Through various studies conducted by its brand, in addition to further trials by Viking Pharmaceuticals, users reported the mineral density in their bones improved.
This revelation serves to be a potential game changer in treating conditions osteoporosis and similar ailments that affect all ages. Particularly those who are older.
Perhaps more exciting, those who used ligandrol cited more strength in their muscles and the ability to keep lean body mass consistent.
LGD-4033 was safe, had favorable pharmacokinetic profile, and increased lean body mass even during this short period without change in prostate-specific antigen. Longer randomized trials should evaluate its efficacy in improving physical function and health outcomes in select populations.
The Safety, Pharmacokinetics, and Effects of LGD-4033
Why Is LGD-4033 More Popular In Medical Groups?
Any licensed physician will tell you that anabolic steroids will ultimately lead you down a risky path. Especially if you are harboring preexisting conditions. The fact that ligandrol acts as a Swiss army knife of effectiveness in numerous areas is why its popularity has jumped exponentially.
To be able to treat serious conditions bone fractures, while simultaneously boosting cut, round muscles is extremely appealing, compounded by the fact that its side effects are minimal.
How Can This SARM Help Bodybuilders Specifically?
Your goals will dictate if ligandrol is a fruitful direction to take your body, but the biggest reason it is being used by the masses currently is to produce lean muscle mass without taking on more fat. If you are a regular at the gym you know that this fat is your adversary.
And something you want to avoid at all costs. LGD-4033 aids in this by being anti-catabolic. This is crucial because it means there is less muscle breakdown between workout sessions.
Users of this SARM state that fat loss is easier because their metabolism functions more effectively.
Targeting bone and muscle tissue is coveted by those in pain or desiring quicker recovery times. Brittle bones deteriorate at a faster rate than those that are strengthened by nutrients your body craves. Because LGD-4033 delivers added power behind movement and muscle activity.
Since weightlifting can causes fatigue, it is no surprise that incorporating ligandrol can increase stamina. Since time to recoup with its use moves more swiftly. This is a bombshell of good news to those wanting to train harder and longer with few drawbacks.
What Are The Side Effects Of LGD-4033?
To be clear, there are no specific reports on extensive damage with regular LGD4033 use.
But this does not give individuals a free pass to abuse it.
Headaches, fatigue (initially) and hair growth are a few potential side effects. But nowhere near the concerns raised by anabolic steroids. Common sense is more profound than the effects of the SARM itself, so a responsible user is a prepared one.
What Are The Doses Of Ligandrol And When Do You See Results?
10mg per day seems to be the sweet spot for gym rats aiming to cut and limit body fat. We recommend a cycle of 8 to 12 weeks. Women should take lower doses at around 5mg to be on the safe side.
Users should note that less is more initially. And you can always increase your dose to give your body time to adapt to its influence.
(before capping it off at 10mg a day) After about a month of use, you can typically recognized positive results.
How To Get The Most LGD-4033
Similar to taking standard supplements creatine, ligandrol flexes its muscle when used with a balanced diet and well thought out regiment.
This is not just about working out, as even a plan for recovery can suffice.
Consistency, moderation of doses, and the meals you pair it with will determine if it hits a home run for you in creating lean body mass and improving bone and muscle strength.
By eliminating anabolic steroid effects of bloating and organ disruption, LGD-4033 is an exciting, efficient and fast working supplement. It can help a wide variety of individuals in a multitude of problematic areas.
Where Can I buy Ligandrol?
User can buy ligandrol as research chemicals only. With so many fake sources available, you should only buy LGD-4033 from a trusted provider.
Does Ligandrol (LGD 4033) Work? There Is Promise in the Research
After finishing reviewing Beta-Alanine, D Aspartic Acid, and Cissus, I decided to turn my attention to something a little more controversial. Ligandrol was a natural choice.
Ligandrol or LGD-4033, is a selective androgen receptor modulator (SARM) discovered by Ligand Pharmaceuticals and currently under development by Viking Therapeutics , .
That sounds very technical and it is! I will elaborate more on what this means in the next section.
LGD was developed for the treatment of muscle wasting conditions, such as aging, osteoporosis, muscular dystrophy and cancer.
Why is this important? Well, in the case of cancer alone, for example, the prevalence of muscle loss has been reported as between 20% and 70%, depending on the type of tumor and the criteria used for assessment .
Muscle wasting, including a loss of skeletal muscle, is a cancer-related symptom that begins early in the progression of cancer and affects a patient’s quality of life, ability to tolerate chemotherapy, and survival .
In addition to legitimate medical uses, it is also being used as a performance-enhancing drug. In the body-building world, LGD is being promoted as a side-effect free alternative to steroids, such as testosterone, to increase lean muscle mass and athletic performance.
The drug is popular with a wide range of athletes and professionals who are conscious of their muscle size and body composition, including weight lifters, bodybuilders, models, crossfitters, athletes and strongmen.
Recently, there has been a lot of hype around LGD. Although it is not a steroid, Ligandrol has been making headlines lately for getting athletes in trouble for taking illegal performance-enhancing supplements. Florida Gators quarterback Will Grier was found to have Ligandrol in his system during a routine test , .
SARMS LGD, which are developed for therapeutic use, are often misused by athletes as doping agents and or for image-enhancement. This has generated a market for counterfeit doping substances, which may be of poor pharmaceutical quality and therefore constitute health risks to consumers .
Since LGD is getting a lot of publicity, it’s worthwhile taking a look at the research.
What Actually Is Ligandrol?
LGD-4033 is a non-steroidal selective androgen receptor modulator (SARM).
An androgen (from Greek ‘andro’ meaning male human being) is a compound (natural or synthetic) that regulates the development and maintenance of male characteristics in vertebrates (including humans) by binding to androgen receptors (special receptors on cells). Androgens are often steroid hormones.
A selective androgen receptor modulator (SARM) is selective in its target tissues in the body. That means it has a high affinity to bind with androgen receptors. Being “selective”, SARMS can be taken by mouth but only binds to specific target areas- in this case – to androgen receptors in your muscles.
There are many conditions that result in muscle wastage. As we age, we lose lean muscle mass and muscle strength, which is called “Sarcopenia”. Sarcopenia is known to increase the risk of falls, fractures, physical disability, and result in poor quality of life with significant health and economic effects.
Similarly, many illnesses, such as chronic obstructive lung disease, muscular dystrophy, end-stage renal disease, and some types of cancer, is punctuated by the loss of lean muscle mass and physical function, which contributes to mobility limitation and disability , .
Thus, there is a need for anabolic therapies that combat lean tissue loss and physical function and reduce the burden of disability in persons experiencing it due to aging or illness . Among the various candidate anabolic therapies that are in development, androgens are the farthest along in development .
It is widely recognized that testosterone administration increases muscle mass and strength but concerns regarding its potential adverse effects have motivated efforts to develop SARMs, a new class of androgen receptor ligands that are tissue-selective . SARMs modulate the same anabolic pathways targeted with classical steroidal androgens8.
The last decade has witnessed substantial pharmaceutical efforts to develop nonsteroidal SARMs to treat muscle wasting and functional limitations associated with acute and chronic illness and aging.
This class of SARMs has been the subject of much clinical research over the past two decades8. LGD-4033 binds androgen receptors with high affinity and selectivity, ie it binds in a strong and targeted manner . It is expected to produce the therapeutic benefits of testosterone with improved safety, tolerability, and patient acceptance.
How Much Research Is There?
There has been a lot of research into the efficacy of SARMs but very little published research to date on LGD.
LGD-4033 has exhibited desirable in vivo effects on skeletal muscle and bone measurements in animal models of disease. There is only one published study on the effects of LGD in humans as well as Phase I Clinical Trial results.
A 2010 Phase I clinical trial was the first study in humans of LGD-4033, and evaluated the safety, tolerability and pharmacokinetic effects (how it acts in the body) of the molecule in a single escalating dose, double-blind, placebo-controlled study in 48 healthy volunteers.
In 2013, Basaria conducted a rigorous 3-week placebo-controlled study of 76 healthy men (21–50 years) that looked at the safety and tolerability of LGD-4033. It hopefully paves the way for longer-term efficacy trials in one or more populations of older individuals for which SARMs may be indicated .
During this study, participants were randomized to placebo or 0.1, 0.3, or 1.0 mg doses of LGD-4033 daily for 21 days. The study evaluated the safety, tolerability, pharmacokinetics (how it works in the body), and effects of ascending doses of LGD-4033 administered daily for 21 days on lean body mass, muscle strength, stair-climbing power, and sex hormones .
Despite being a well designed, thorough study, the sample size, although substantially larger than in most phase I ascending-dose studies, was still fairly small, was not considerations of effect sizes , as the study’s primary aim was to establish safety and tolerability rather than efficacy. Similarly, the 3-week study duration was not designed to demonstrate maximal effects on muscle mass and strength . Therefore larger and longer studies are needed to assess the efficacy of LGD.
One further thing to note is that the study was supported by Ligand Pharmaceuticals, who developed LGD, so it’s impossible to say that the research was completely impartial.
Does Ligandrol Increase Testosterone?
No. Research by Basiria showed a dose-dependent suppression of total testosterone and from baseline to day 21 , rather than an increase.
Does Ligandrol Promote Fat Loss?
No. The research does not show that LGD promotes fat loss .
Does Ligandrol Promote Muscle Growth?
Yes. But it’s very early, weak evidence at this stage. The research by Basiria showed an increase in lean body mass that was dose related, so as the dose of LGD taken increased, so did the effect of increased muscle mass .
The mechanisms by which androgens increase muscle mass remain incompletely understood . It would be plausible that increased muscle mass would translate into increased muscle strength.
Research has shown that SARMs increase muscle mass and improve physical function in healthy and diseased individuals and potentially may provide a new therapy for muscle wasting, especially in the case of cancer8.
However, the increase in strength measured by stair climbing speed and power also showed improvement, but not enough to be statistically significant. With a larger sample size and or a longer study, it is possible that this effect may be demonstrated.
If You’re Using It Anyway…
You probably shouldn’t be, as there is not enough research yet. But no adverse effects have been noted at this stage.
How Long Does It Take To “Kick In”?
LGD-4033 displayed an immediate effect on hormones in the body from the time it was taken. In terms of functionality, the research showed gains in lean muscle mass within the 21-day study, which is a pretty amazing result for a short space of time .
How Long Does It Stay In Your System?
LGD-4033 displayed a prolonged elimination half-life, which means the time it takes for half of the dose to leave your system, of 24–36 hours. That is every 24-36 hours, the level of LGD in your system drops by half . The following day, the level drops by half again, and so forth.
Upon discontinuation of LGD-4033, the hormone levels returned to baseline by day 56 .
Is Ligandrol Safe? Are There Side Effects?
Both the Phase I Trial and study by Basiria showed that LGD-4033 was safe and well-tolerated at all doses administered (0.1mg, 0.3mg, and 1.0mg). The frequency of adverse events was similar between the placebo and any dose group. Headache, pain related to muscle biopsy, and dry mouth were the most common events and did not show dose relationship.
One of the clinically useful features of LGD is its half life. Its prolonged elimination half-life means that is can be given once daily or even a less frequent dosing regimen. Research showed that there was a robust relationship between the dose and the blood plasma concentrations.
Conclusion: What Should We Think About Ligandrol?
The past decade has witnessed the emergence of a number of nonsteroidal SARMs from several pharmaceutical companies as a new class of function-promoting therapies to treat the loss of muscle mass.
Recent clinical efficacy data for LGD-4033 is very promising, showing it to be safe and able to increase lean body mass even during a three week period, which is a fantastic result in a short time. But it must be remembered that this was recorded in a single study with a small sample size (76 people), and the Phase I Clinical trial also had a small sample size (48 people).
There just is not enough research to show its efficacy at this stage, despite it looking super promising!
Although future research may show LGD to be safe and efficacious, the evidence is just not strong enough to support it right now. Given the global burden of diseases that involve muscle wastage, including aging, cancer, and osteoporosis, it is very ly that further research and trials will come out with stronger evidence for its clinical usage.
A Complete Guide to Ligandrol (LGD-4033) -Updated August 2019-
All bodybuilders have one goal: to lose fat and build big muscles. However, many people hit a roadblock after months of working on the heavyweights. They’ve bulked up, but they’re still unable to burn the fat. They have abdominal muscles, but it’s all hidden under a layer of fat.
That’s why they turn to supplements Ligandrol, one of the most popular and selective effective androgen receptor modulators (also called SARMs) in the fitness community. For many bodybuilders and athletes, Ligandrol has become an effective, safe and convenient way to improve both their gains and their performance.
HOW DOES LIGANDROL HELP BODYBUILDERS?
Ligandrol, also known as Lgd-4033, was initially developed by pharmaceuticals to help the elderly or people suffering from cancer or muscular dystrophy.
These patients offer to suffer from muscle loss. However, regular use of LGD-4033 helped them rebuild muscle by binding to their body’s androgen receptors.
They also showed that they had higher energy levels, and had better endurance and stamina.
The fitness industry saw that this substance could benefit bodybuilders and athletes, and started marketing LGD-4033 as a safer alternative to steroids. Positive reviews started pouring in. Users said that they show faster muscle gain – some claim that Ligandrol can even lead to a gain of ten pounds of lean muscle in one cycle
Bodybuilders also said this SARM was very effective at building lean muscle. Their body was more efficient at burning calories and fat, so those six-pack abs were showing through!
Athletes, on the other hand, used LGD 4033 to improve their performance. Ligandrol increased their endurance and stamina, allowing for more efficient training, and better results.
Bear in mind, however, that there have been professional athletes that were penalized for using this compound before competitions.
Be sure to discuss Ligandrol intake with your trainer or coach to avoid any possible conflicts or problems down the road.
Why is LGD-4033 BETTER THAN STEROIDS?
SARMs and steroids work in similar ways in the sense that they both bind to androgen receptors in the body to improve your muscle growth and development.
However, SARMs Ligandrol are more tissue-selective, which means that they are able to target specific muscle and bone tissues. Steroids will bind to all androgen receptors, including those in the liver, prostate, and sebaceous glands.
That’s why long-term steroid use has been associated with a lot of dangerous side effects: higher risk of prostate cancer, kidney and liver damage, osteoporosis.
And since steroids also affect the body’s estrogen levels, even short-term use can lead to acne, hair loss, bloating, and higher blood pressure.
SARMs does not pose these health risks since it only acts on muscles and not the vital organs of the body. So think of SARMS and steroids as the difference between a sniper bullet and a machine gun: SARMs can hit the target without a lot of collateral damage.
Aside from this, SARMs LGD-4033 is more convenient for people to use. Steroids are typically taken in injection form to “localize” the effects to muscle tissue. Once it enters the bloodstream, it can damage other organs. However, LGD-4033 can be safely ingested as a pill. Ligandrol is even considered one of the safer pills because it isn’t metabolized by the liver.
All in all, Ligandrol is a much safer alternative to steroids and is considered one of the safest forms of SARMs.
WHAT ARE THE POSSIBLE SIDE EFFECTS OF TAKING LGD 4033?
Any side effects are minimal. The worst side effect that people have reported while taking LGD-4033 is occasional nausea (usually quite mild), headache and nausea. These symptoms usually appear when you begin taking Ligandrol, but disappear as your body adjusts to it.
To avoid these side effects, you just need to increase your water intake. If symptoms continue to persist or become unbearable, lower your dosage or talk to your doctor.
You should also talk to your trainer or coach. Symptoms a headache and nausea are often signs of over-training and may be attributed not to Ligandrol itself but the temptation to increase your workout beyond safe and reasonable limits.
WHAT IS THE MOST EFFECTIVE DOSE OF LIGANDROL?
LGD-4033 is dose-specific, so you get better results with higher doses. However, don’t be tempted to take high levels right away, since your risk for side effects will increase because of the “shock” to your system.
If you are taking LGD-4033 or any SARMs for the very first time, it is better to start with a small dose of five milligrams per day. You can then gradually increase your dose to 10 milligrams, although there are studies that women should stay at an upper limit of 5 milligrams. In general, that dosage is enough to improve your performance within a 24 to 36 hour period.
Some bodybuilders have gradually increased their dosage to 20 milligrams a day, but that’s very high on the spectrum. They did not report any negative side effects, and there have been no incidents of anyone overdosing on LGD-4033. Nevertheless, most trainers and coaches advise against such megadoses, especially if you are using other types of supplements at the same time.
HOW LONG WILL IT TAKE TO SEE RESULTS?
Results depend on many things: your body type, training levels, and other genetic factors that affect your body’s ability to burn fat and build muscle.
However, it is possible to see gains (such as being able to lift heavier weights or increase the duration of a workout) in as short as two to three weeks when using Ligandrol.
Gains will increase until the sixth week and then begin to plateau as your body develops a tolerance to it.
CAN I STACK LIGANDROL WITH OTHER SUPPLEMENTS?
Yes, you can stack LGD-4033 with other SARMs Cardarine, Ostarine or Testolone. In fact, many bodybuilders and athletes will combine supplements to achieve their particular fitness goals.
However, trainers recommend that you avoid using many SARMs at the same time.
If you’d to combine pills, you can increase your dose of anabolicum or other types of supplements rather than making one big SARM cocktail.
DOES LIGANDROL PROMOTE WEIGHT LOSS?
Lgd-4033 is better at building lean muscle mass and improving your strength and endurance. Any fat loss is more of a very good side effect. Since you get a better workout and build more muscles, you’re able to burn more calories all throughout the day.
But, as a chemical compound, it doesn’t actually directly affect your body’s ability to burn fat.
So, you can’t take Ligandrol as a diet or fat loss pill, and don’t believe anyone who markets it in that way! If you want to become slimmer and shed the belly, you’ll have to do the work at the gym.
HAVE THERE BEEN CLINICAL TRIALS ON LIGANDROL?
The studies of LGD-4033 as a bodybuilding supplement are still on-going. However, research has been promising.
In one study, 76 adult males were given either a placebo or a 1.0-milligram dose of LGD-4033 for 21 days. Those who took LGD-4033 showed an improvement in their lean muscle mass, better muscle strength, and better performance on endurance exercise (such as climbing up the stairs).
There are also clinical trials that test its ability to heal damaged muscles, particularly among people who are recovering from hip fracture surgery.
Several groups are continuing to discover and test the many benefits of LGD-4033 to muscle and tissue development.
WHAT DO PEOPLE SAY ABOUT LIGANDROL?
There is a lot of anecdotal evidence and customer testimonials from people who have seen the results for themselves.
“In my first cycle, my core lifts improved by 25!” says one user. Another said that he’s finally seeing some gains in his upper body. “I’ve been lifting for over a year, but most of my gains have been in my leg muscles. I could barely see any improvement in my arms and chest. After taking Ligandrol, my upper body is starting to look rounder and more muscular.”
Another user says that this SARM is one of the only supplements he’s taken that have no uncomfortable side effects. “With the other pills, I sometimes experience diarrhea or stomach pain, which can be quite inconvenient when I’m outside. The only side effect I got from LGD-4033 was a dry mouth, and that symptom disappeared after my first week.”
Many bodybuilders who have tried different supplements say that not only do their muscles feel harder and fuller the whole day, but they also feel more positive and powerful.
Many pills that affect hormones can cause mood swings, where you feel really happy and energetic one moment and then suddenly “crash” – become cranky, listless, or even depressed.
With this product, your good energy levels and moods stay consistent the whole day.
WHERE CAN I GET LGD 4033?
Ligandrol is a great supplement to increase muscle mass fast. It is important to buy LGD-4033 and other SARMs from credible sellers. Fake supplements may be cheaper, but they can cause more adverse side effects or even long-term health risks. They are also less effective at delivering benefits improved muscle gain, endurance, and stamina.
Buy LGD-4033 from #1 USA supplier approved by EF & EVO
A Better Body in a Pill? Experts Urge Caution on SARMs
Continue reading the main story
Many athletes and gym-goers are turning to a popular but potentially dangerous new pill to help them build muscle and gain strength: a steroid alternative known as SARMs.
The pills are widely marketed online as “legal steroids” that provide the muscle-building benefits of anabolic steroids without the troubling side effects. And while the products are legal — at least so far — their spread has alarmed health authorities, who say they are not necessarily safe.
Drug companies developed SARMs, which stands for selective androgen receptor modulators, as an alternative to anabolic steroids for people who suffer from age and disease-related muscle loss. But they are the subject of ongoing clinical trials and have not been approved for use by the Food and Drug Administration.
In October, the agency issued a public advisory cautioning that SARMs were unapproved drugs linked to “serious safety concerns,” including the potential for an increased risk of liver toxicity, heart attacks and strokes.
A month later, a study published in JAMA revealed that products marketed as SARMs were frequently misbranded and tainted with unlisted ingredients.
44 products that were purchased online and analyzed, only about half contained an actual SARM, while 10 percent contained none at all. Roughly 40 percent had other hormones and unapproved drugs.
Several contained a drug that was abandoned by GlaxoSmithKline a decade ago after it was found to cause cancer in animals.
The long-term consequences of using SARMs are largely unknown, and people who purchase products marketed as them cannot be entirely sure what they are putting in their bodies, said Dr. Shalender Bhasin, the director of research programs in men’s health, aging and metabolism at Brigham and Women’s Hospital and an author of the JAMA report.
“We don’t know whether these compounds are safe,” he said, “but we do know that some of them have side effects.”
That has not stopped many people from experimenting with them.
Thaddeus Owen, 42, a self-described biohackerwho lives in Saint Paul, Minn., began using SARMs in 2016 in combination with a diet and exercise program.
He said that the pills helped him pack on five pounds of muscle in four weeks, which he documented on his website, “PrimalHacker.
” He argued that informed adults should be allowed “to experiment on ourselves and improve our biology,” but added, “this is definitely a use-at-your-own-risk type of supplement.”
Anti-doping officials have known about SARMs for some time and have seen an increasing number of elite athletes using them. Since 2015, the United States Anti-Doping Agency has imposed sanctions on more than two dozen track and field stars, weight lifters, cyclists, mixed martial artists and others for testing positive for a variety of SARMs, most frequently one called ostarine.
Last year, Joakim Noah, a center for the New York Knicks, was suspended for 20 games for testing positive for a SARM. The college basketball star Allonzo Trier of the Arizona Wildcats was also suspended for using SARMs. And in October, a top CrossFit Games competitor, Ricky Garard, was stripped of his third-place title after testing positive for two SARMs: ostarine and testolone.
While the underground use of SARMs has made them controversial, the drugs could one day serve a crucial purpose for many patients.
Scientists developed SARMs decades ago to counter the age-related decline in muscle and strength that tends to begin around middle age and that can contribute to falls and broken bones. Many chronic diseases, such as cancer, heart failure and kidney disease, are also punctuated by a loss of muscle and physical mobility.
Anabolic and androgenic steroids such as testosterone can help people regain muscle and physical function. But they act on many tissues throughout the body and have been tied to a litany of potential side effects, including prostate problems and cardiovascular events.
SARMs were designed to selectively target skeletal muscle and spare other tissues, in an attempt to reduce some of these unwanted side effects. A number of trials are looking at their usefulness in cancer patients, people recovering from hip surgery, and postmenopausal women with urinary incontinence linked to weak pelvic muscles.
A three-week trial at Boston University demonstrated that LGD-4033, a SARM developed by Ligand Pharmaceuticals, was safe and tolerable in healthy men, producing “significant gains in muscle mass and strength” without raising levels of a protein linked to prostate cancer. But it had other effects as well, for instance causing a drop in HDL cholesterol, the protective kind, which raised questions about its effects on heart health.
“Long-term studies are needed to clarify the effects of long-term SARM administration on cardiovascular risk,” the authors concluded.
Thomas O’Connor, a doctor who founded a men’s health clinic and wrote a book called “America on Steroids,” said that many of his patients are anabolic steroid users who turned to SARMs because they were told that they were safe and nontoxic. He said that since 2010 has seen “hundreds, maybe over 1,000 men on SARMs” from all walks of life: police officers, defense workers, amateur athletes, accountants and others.
It’s hard to determine the precise impact of SARMs because many people who use them combine them with other drugs, supplements and substances, Dr. O’Connor said.
But one thing he often sees among people using SARMs is that their cholesterol profiles worsen and their liver enzymes rise, a sign of increased strain on their livers.
Some also experience diminished sex drive, hair loss, acne and irritability, though it’s often difficult to know whether it’s the SARMs causing these symptoms or some other unlisted ingredients in the products.
As a longtime power lifter, Dr. O’Connor said he relates to a lot of his patients and understands their desire to be bigger, stronger and fitter. But he counsels them to give up the drugs they are using because they are jeopardizing their health.
“I always tell them the same thing,” he said. “These are illicit agents. They’re not supported by expert guidelines and they’re dangerous. So don’t take them.”
The Council for Responsible Nutrition, a supplement industry trade group, launched a campaign on social media, #SARMSCanHarm, and is working with sports clubs, fitness groups and coaches around the country. The military and federal government also have an awareness campaign about risky products called Operation Supplement Safety.
Patricia Deuster, a professor of military and emergency medicine at the Uniformed Services University of the Health Sciences, said SARMs are popular among some soldiers because they are easier to access than anabolic steroids, but she warns them there are hazards, citing one soldier who suffered liver damage and could not deploy with his unit because he was hospitalized after using a product containing SARMs and other ingredients.
“We try to tell them that there are other ways that they can achieve their goals without risking their health or their ability to maintain their deployment status,” Dr. Deuster said. “We are trying to educate them.”
“,”author”:”Anahad OâConnor”,”date_published”:”2018-04-12T10:02:06.000Z”,”lead_image_url”:”https://static01.nyt.com/images/2018/04/17/well/pill-body/pill-body-Jumbo.jpg”,”dek”:null,”next_page_url”:null,”url”:”https://www.nytimes.com/2018/04/12/well/move/sarms-muscle-body-building-weight-lifting-pill-supplements-safety.html”,”domain”:”www.nytimes.com”,”excerpt”:”Bodybuilders are turning to a popular new pill to get bigger and stronger, but the chemicals are still undergoing testing and could cause serious harm.”,”word_count”:1126,”direction”:”ltr”,”total_pages”:1,”rendered_pages”:1}
Ligandrol LGD-4033: A Safer Alternative for Anabolic Steroids? – Providence Hospital
Nowadays, LGD-4033 (Ligandrol) has become the hottest topic. Although SARMs were primarily researched and also used in addressing chronic diseases, muscle loss, and osteoporosis, their use has stretched out to weightlifters and people looking for safer alternatives to anabolic steroids.
Anabolics have for years run rampant within the bodybuilding community, and many people know about all the dangers they come with. And to avoid the nasty side effects from using Anabolics, more and more people are opting for SARMS (selective androgen receptor modulators).
Fortunately, more info has become readily available for the general public regarding this supplement.
The thing with SARMs is that their action is far more selective within your body. This is advantageous for you as you take them since they won’t harm your organs.
In this review, we are exploring all about Ligandrol or LGD-4033. Therefore, to determine its effects, dosage and everything you need to know about it, it’s important we delve deeper into what Ligandrol LGD-4033 is and how it can help.
History of Ligandrol
Originally, Ligandrol was developed in the early 2000s by Ligand Pharmaceuticals to help prevent muscle wasting in patients with cancer and muscular dystrophy. However, today bodybuilders argue that Ligandrol can boost muscle mass, accelerate bone injuries healing, and also prevent issues osteoporosis.
After a while, Viking Therapeutics acquired Ligandrol research rights and renamed it 5211 from LGD-4033. Today, Viking Therapeutics is studying Ligandrol for use in hip fracture therapy.
Also, researchers maintain their positive effects on your body’s hormone levels. The aim of SARM therapy for patients with fractures is to:
- Improve your muscle and bone strength
- Boost your lean muscle mass
- Enhance your overall athleticism
Overall, its benefits for individuals with hip fractures appear to be related to the goals of all athletes from across the globe. That’s why many people are turning to SARMs for bodybuilding.
Even with the high praises, WADA (the World Anti-Doping Agency) has categorized Ligandrol under prohibited drugs. Meaning, athletes cannot participate in major sporting events while under this drug.
With this in mind gym-goers will find this surprising that regardless of the negative press coverage on Ligandrol, more people still take it as a replacement for anabolic steroids.
Even then, Ligandrol is among the most popular SARMs Ostarine and Testolone.
Next, let’s consider how it works to give you such amazing results.
Ligandrol Mechanism of Action
LGD-4033 and in general, all SARMs work by stimulating specific androgen receptors in your body.
As a result, you’ll have a powerful steroid- effect, fortunately, without the nasty side effects you’d get from using prohormones or steroid.
That’s why so many people turn to it. Using Ligandrol can offer you the many benefits of steroids without the drawbacks.
In addition, take note that as for the first generation of LGD-4033, that is SARMs created by Ligand Pharmaceuticals, they provided an average but steady effects on your lean muscle mass.
LGD-4033 and Bodybuilding
Remember that your goals will determine whether Ligandrol is the route to take to achieve your fitness goals.
But, the main reason why it’s currently used by more and more people is that it produces lean muscle mass without retaining more fat.
If you train regularly, then you know that fat is your opponent something you should avoid at any cost. That’s when LGD-4033 can help you by being anti-catabolic.
And this is important since this means there’s reduced muscle breakdown between training sessions. Ligandrol users say that fat loss a lot easier as their metabolism is more effective.
Also, targeting muscle and bone tissues is desirable by people in pain or looking to have faster recovery times.
Note that, brittle bones tend to deteriorate much faster compared to those strengthened using nutrients that your body craves.
And to prevent this, LGD-4033 delivers you added power to support muscle activity and movement.
Again, weightlifting can lead to fatigue thus it’s no wonder that incorporating Ligandrol to your arsenal helps increase your stamina. This is because the time to recover when using it moves speedily.
Such is good news especially for those looking to train longer and harder with fewer drawbacks. To benefits from similar benefits order your Ligandrol today and enjoy a 30% discount.
Ligandrol Half-Life, Dosage and Cycle
Note that Ligandrol’s half-life is 24 – 36 hours. And many athletes use Ligandrol daily for a duration of 8 -12 weeks. When taking Ligandrol, men should ingest about 10mg daily, and women should take a maximum of 5 mg only.
All the same, some users recommend shorter cycles to prevent tolerance. For instance, during bulking, you can stop at 3 to 6 weeks and take a 4-week break which allows you to recover your natural testosterone levels.
Also, keep in mind that traces of Ligandrol can be found in your urine for as long as 7 days after using this SARM.
If it’s great results you are after while cutting, you can stack Ligandrol with Cardarine and Ostarine.
And when bulking, stack it with Testolone. Lastly, if you prefer body recomposition, then stack it Cardarine as it will improve the effects of Ligandrol.
Now that we’ve looked at how to cycle and take Ligandrol, what can you expect from using it? Keep reading to learn more about its benefits.
#1.Prevents Muscle Wasting
Medical researchers claim that Ligandrol is effective in combating muscle breakdown among cancer patients. And to gain similar gains, many healthy bodybuilders use it to get a larger physique.
While SARMs have similar anabolic effects steroids, they luckily do no cause androgenic complications male pattern baldness, prostate cancer and facial hair growth.
Also, whereas they can increase your free testosterone levels, the sex hormones don’t convert into estrogen.
In a study on how LGD-4033 works, 76 healthy men ingested this compound gradually in increasing amounts beginning from 0.1mg to 1mg daily.
After 3 weeks, the results indicated that using 1mg of Ligandrol LGD-4033 a day helped increase lean muscle mass as well as athletic performance.
Defining Cachexia: This is muscle weakness and deterioration resulting from chronic diseases kidney complications, cancer and others.
Before Ligandrol, many researchers tested the Nandrolone steroid and its impact on Cachexia.
Although it helped lessen the symptoms, it came with major side effects such as developing liver toxicity and secondary male characteristics in women.
As for male patients with HIV, testosterone helped improve their muscle strength and even mass.
However, it also increased their risk of getting prostate cancer and even having an imbalance in their red blood cells levels.
#3.Preventing and Healing Osteoporosis and Bone Fractures
To prevent bone fractures and osteoporosis, the best way would be to strengthen your bone formation and increase your mineral density.
That being said, Ligandrol can be used to address this as it binds to androgen receptors found in your bones and thus strengthens them.
Also, the study indicates that SARMs are even more effective compared to DHT (Dihydrotestosterone) when considering increasing bone formation and strength.
#4. Mood Enhancement
When it comes to SARMS effects in enhancing your mood, more research is needed to verify this. This is since there is no sufficient research around the impacts of SARMs on your brain.
But, it can activate your brain’s androgen receptors. Then again, the enhanced libido and mood might be an effect following the increase in your strength, energy and stamina levels.
#5.Potential Male Contraception
When we are talking contraceptives, men seem to have few choices. So, men who aren’t as excited when using the same methods, SARMs can be a possible option for you.
Ligandrol prevents gonadotropins production in your pituitary gland. These hormones are necessary for reproduction (that is pregnancy and for fertility).
Pills, Powder or Liquid: Which is Best?
SARMs are offered in many different forms and the ly forms you’ll see are pills/capsules, powders or liquids. We, however, prefer the liquid form of Ligandrol for below-listed reasons:
- Liquids can be dosed easily compared to powders or pills
- You can easily store them in a cabinet
- It’s also a more accurate way of dosing from the manufacturers’ side.
The thing is, for you to accurately dose pills or capsules you’ll require machines that cost thousands of dollars.
And mainstream supplement companies have access to this, which might be the case for most small labs.
Therefore, you should be very careful when you decide to get capsules or pills. With that in mind, we always recommend the liquid solutions of SARMs.
Any Side Effects when Using LGD-4033?
So far, have been no specific reports on the side effects with regular use of LGD-4033. But this should not serve as a free pass for people to abuse it.
Hair growth, headaches, and fatigue (initially) are some potential side effects. Though they are nowhere near the levels experienced by anabolic steroids.
That being said, being prepared is the best route to take before getting any supplement.
Finding Pure Ligandrol for Sale
For a while now, we’ve tested and reviewed different Ligandrol LGD-4033 sources and unfortunately, most have turned out to be fake.
While some of these vendors are only in it for a quick buck, which makes it hard for a consumer to get a reliable source.
From our findings, our recommended supplier for all your SARMs needs is Proven Peptides. Plus they have 3rd-party results that show they are offering real SARMs.
Guys, this is very crucial – no one wants to end up getting a fake product which can potentially compromise your health.
So, if you’re in search of a legit place that offers Ligandrol for sale, then visit Proven Peptides online. Alternatively, click here and enjoy a 30% off deal with free shipping on orders above $75.
If you combine this offer with their prices, getting your SARMs from them is no brainer. Proven Peptide is a US-based company that offers LGD-4033 in liquid solutions.
How to Buy Ligandrol LGD-4033
Ligandrol has not been banned for public consumption and it’s legal to sell as well.
That said it is, however, banned for pro athletes or those who practice collegiate sports. This is because it’s considered to be a performance-enhancing drug.
If you’re looking for Ligandrol for sale, then consider to buy it from reliable online sellers or follow this link for the best deal on Ligandrol.
Not only is this more affordable compared to other SARMs in its class, but it’s more effective. (Our team has had great results with SARM products from Proven Peptides).
They are the best SARMs provider on the market today.
And if you’re considering getting Ligandrol for sale then visit Sarms4You website to take advantage of the limited sale running on their SARM products. Plus you are guaranteed to get legit SARM s.
What’s more, a single Ligandrol supply will last you for a long time this is considering the recommended dose is only 5 mg-10 mg a day.
As we had mentioned earlier about LGD-4033, this compound also comes in the form of capsules which you take orally. And this means you don’t have to endure those painful needles or injections.
But because the quality of this supplement is very important, we recommend getting your dose from Sarms4You for best deals.
The bodybuilding and fitness industries are awash with different supplements and new SARMs are entering the market ever so often.
And this only makes it more difficult to choose an option that best suits your needs as there are so many varieties to choose from.
Fortunately, Ligandrol makes deciding a lot easier since it offers fast and superior results with no side effects that you would expect from anabolic steroids.
This makes SARMs a great option for you if you are seeking superb results yet avoid using steroids.
But, today there are many fake products on the market.
So, to avoid such products, make sure you only purchase from reliable vendors or visit Proven Peptides, a US-based manufacturer that offers high-quality Ligandrol.
Remember, a proper PCT is important when taking these compounds. For this, we suggest taking Rebirth PCT as you can buy it over-the-counter and it uses a solid formula.