What is Ranitidine (Zantac®)? + Side Effects & Interactions

Ranitidine (Zantac): Side Effects, Dosages, Treatment, Interactions, Warnings

What is Ranitidine (Zantac®)? + Side Effects & Interactions

Ranitidine is a prescription drug used to treat ulcers of the stomach and intestines and to prevent intestinal ulcers from coming back after they have healed.

Ranitidine is also used to treat certain stomach and throat problems such as erosive esophagitis, gastroesophageal reflux disease or GERD, and Zollinger-Ellison syndrome. It works by decreasing the amount of acid your stomach makes.

It relieves symptoms such as cough that doesn't go away, stomach pain, heartburn, and difficulty swallowing. Ranitidine belongs to a class of drugs known as H2 blockers.

Ranitidine is available under the following different brand names: Zantac, Zantac 150 Maximum Strength, and Zantac 75.

Dosages of Ranitidine

Adult and pediatric dosages:

Injection solution

Syrup

Tablet

Dosage Considerations — Should Be Given As Follows:

Adult Dosage Considerations

Gastroesophageal Reflux Disease

  • 150 mg orally every 12 hours or 50 mg intramuscular/intravenously every 6-8 hours

Gastric Ulcer, Benign

  • Treatment: 150 mg orally every 6 hours or 50 mg intermuscular/intravenously every 6-8 hours intermittent bolus or infusion; alternatively, 6.25 mg/hours intravenously by continuous infusion
  • Maintenance of healing: 150 mg orally every 12 hours

Hypersecretory Conditions

  • 150 mg orally every 12 hours, up to 6 g/day used
  • Parenteral: 50 mg (2 mL) intramuscularly or intermittent intravenous bolus or infusion every 6-8 hours, not to exceed 400 mg/day; alternatively, 6.25 mg/hour continuous infusion

Dosing Considerations

More frequent doses may be necessary, individualize dosage, and continue as long as indicated; dosages up to 6 g/day have been used for severe disease.

Zollinger-Ellison syndrome: Start intravenous infusion at 1 mg/kg/hour, then adjust upward in 0.5 mg/kg/hour increments according to gastric acid output (not to exceed 2.5 mg/kg/hour or 220 mg/hour.

Stress Ulcer Prophylaxis (Off-label)

  • 150 mg orally or nasogastric every 12 hours
  • 50 mg (2 mL) intramuscular or intermittent intravenous bolus or infusion every 6-8 hours, not to exceed 400 mg/day; alternatively, 6.25 mg/hour continuous infusion

Dosing Modifications

  • Renal impairment (Creatinine clearance less than 50 mL/min): 50 mg intravenously/intramuscular every 18 to 24 hours or 150 mg orally once daily
  • Hepatic impairment: Dosage adjustment not necessary

Pediatric Dosage Considerations

Active Duodenal/Gastric Ulcer

  • Treatment: 4-8 mg/kg orally every 12 hours; not to exceed 300 mg/day
  • Maintenance: 2-4 mg/kg orally once daily; not to exceed 150 mg/day
  • Parenteral: 2-4 mg/kg/day intravenously divided every 6-8 hours; not to exceed 50 mg/dose or 200 mg/day

Gastroesophageal Reflux Disease (GERD)

Children: 1 month – 16 years

  • 5-10 mg/kg/day orally divided every 12 hours; not to exceed 300 mg/day
  • Parenteral (Off-label): 2-4 mg/kg/day intravenously divided every 6-8 hours; not to exceed 50 mg/dose or 200 mg/day; alternatively, infusion at 1mg/kg/dose once followed by continuous infusion of 0.08-0.17 mg/kg/hour or 2-4 mg/kg/day

Erosive Esophagitis

Children: 1 month – 16 years

  • 5-10 mg/kg/day orally divided every 12 hours; not to exceed 300 mg/day
  • Parenteral (Off-label): 2-4 mg/kg/day intravenously divided every 6-8 hours; not to exceed 200 mg/day; alternatively, 1mg/kg/dose once followed by continuous infusion of 0.08-0.17 mg/kg/hour or 2-4 mg/kg/day

Neonates (Off-label)

Term Neonates (less than 29 days)

  • 2-4 mg/kg/day orally divided every 8-12 hours or 2 mg/kg/day intravenously divided every 8 hours

Prophylaxis against dexamethasone associated ulceration: 0.031-1.25 mg/kg/hour during dexamethasone therapy to maintain gastric pH greater than 4

Prophylaxis against stress ulceration: 2 mg/kg every 12 hours or 1.5 mg/kg intravenously every 8 hours; alternatively, 2 mg/kg over 10 min, followed by continuous infusion of 0.083 mg/kg/hour

Source: https://www.rxlist.com/consumer_ranitidine_zantac/drugs-condition.htm

Omeprazole: Uses, Side Effects & Dosage Guide – Drugs.com

What is Ranitidine (Zantac®)? + Side Effects & Interactions

Generic Name: omeprazole (oh MEP ra zol)
Brand Names:FIRST Omeprazole, Omeprazole + SyrSpend SF Alka, PriLOSEC, PriLOSEC OTC, Zegerid> (Original Formulation)

Medically reviewed by Sanjai Sinha, MD Last updated on May 1, 2019.

What is omeprazole?

Omeprazole is a proton pump inhibitor that decreases the amount of acid produced in the stomach.

Omeprazole is used to treat symptoms of gastroesophageal reflux disease (GERD) and other conditions caused by excess stomach acid. It is also used to promote healing of erosive esophagitis (damage to your esophagus caused by stomach acid).

Omeprazole may also be given together with antibiotics to treat gastric ulcer caused by infection with Helicobacter pylori (H. pylori).

Over-the-counter (OTC) omeprazole is used to help control heartburn that occurs 2 or more days per week. The OTC brand of omeprazole must be taken as a course on a regular basis for 14 days in a row.

Important Information

Omeprazole is not for immediate relief of heartburn symptoms.

Heartburn is often confused with the first symptoms of a heart attack. Seek emergency medical attention if you have chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, and a general ill feeling.

Omeprazole can cause kidney problems. Tell your doctor if you are urinating less than usual, or if you have blood in your urine.

Diarrhea may be a sign of a new infection. Call your doctor if you have diarrhea that is watery or has blood in it.

Omeprazole may cause new or worsening symptoms of lupus. Tell your doctor if you have joint pain and a skin rash on your cheeks or arms that worsens in sunlight.

You may be more ly to have a broken bone while taking omeprazole long term or more than once per day.

Prilosec OTC (over-the-counter) should be taken for no longer than 14 days in a row. Allow at least 4 months to pass before you start another 14-day treatment.

Before taking this medicine

Heartburn can mimic early symptoms of a heart attack. Get emergency medical help if you have chest pain that spreads to your jaw or shoulder and you feel sweaty or light-headed.

You should not use omeprazole if you are allergic to it, or if:

  • you are also allergic to medicines omeprazole, such as esomeprazole, lansoprazole, pantoprazole, rabeprazole, Nexium, Prevacid, Protonix, and others; or

  • you also take HIV medication that contains rilpivirine (such as Complera, Edurant, Odefsey, Juluca).

Ask a doctor or pharmacist if it is safe for you to use omeprazole if you have other medical conditions, especially:

  • trouble or pain with swallowing;

  • bloody or black stools, vomit that looks blood or coffee grounds;

  • heartburn that has lasted for over 3 months;

  • frequent chest pain, heartburn with wheezing;

  • unexplained weight loss;

  • nausea or vomiting, stomach pain;

  • liver disease;

  • low levels of magnesium in your blood; or

  • osteoporosis or low bone mineral density (osteopenia).

You may be more ly to have a broken bone in your hip, wrist, or spine while taking a proton pump inhibitor long-term or more than once per day. Talk with your doctor about ways to keep your bones healthy.

Ask a doctor before using omeprazole if you are pregnant or breast-feeding.

Do not give this medicine to a child without medical advice.

How should I take omeprazole?

Omeprazole is usually taken before eating (at least 1 hour before a meal). Follow all directions on your prescription label and read all medication guides or instruction sheets. Use the medicine exactly as directed.

Use Prilosec OTC (over-the-counter) exactly as directed on the label, or as prescribed by your doctor.

Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.

Shake the oral suspension (liquid) before you measure a dose. Use the dosing syringe provided, or use a medicine dose-measuring device (not a kitchen spoon).

If you cannot swallow a capsule whole, open it and sprinkle the medicine into a spoonful of applesauce. Swallow the mixture right away without chewing. Do not save it for later use.

You must dissolve omeprazole powder in a small amount of water. This mixture can either be swallowed or given through a nasogastric (NG) feeding tube using a catheter-tipped syringe.

Use this medicine for the full prescribed length of time, even if your symptoms quickly improve.

>OTC omeprazole should be taken for only 14 days in a row. It may take 1 to 4 days before your symptoms improve. Allow at least 4 months to pass before you start a new 14-day course of treatment.

Call your doctor if your symptoms do not improve, or if they get worse.

Some conditions are treated with a combination of omeprazole and antibiotics. Use all medications as directed.

Omeprazole can affect the results of certain medical tests. Tell any doctor who treats you that you are using this medicine.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking omeprazole?

Omeprazole can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, call your doctor before using anti-diarrhea medicine.

Get emergency medical help if you have signs of an allergic reaction to omeprazole: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using omeprazole and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;

  • new or unusual pain in your wrist, thigh, hip, or back;

  • seizure (convulsions);

  • kidney problems – little or no urination, blood in your urine, swelling, rapid weight gain;

  • low magnesium – dizziness, irregular heartbeats, feeling jittery, muscle cramps, muscle spasms, cough or choking feeling; or

  • new or worsening symptoms of lupus – joint pain, and a skin rash on your cheeks or arms that worsens in sunlight.

Taking this medicine long-term may cause you to develop stomach growths called fundic gland polyps. Talk with your doctor about this risk.

If you use omeprazole for longer than 3 years, you could develop a vitamin B-12 deficiency. Talk to your doctor about how to manage this condition if you develop it.

Common omeprazole side effects may include:

  • stomach pain, gas;

  • nausea, vomiting, diarrhea; or

  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect omeprazole?

Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.

Tell your doctor about all your current medicines. Many drugs can interact omeprazole, especially:

This list is not complete and many other drugs may affect omeprazole. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Further information

Remember, keep this and all other medicines the reach of children, never share your medicines with others, and use omeprazole only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2020 Cerner Multum, Inc. Version: 20.01.

Medical Disclaimer

Source: https://www.drugs.com/omeprazole.html

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