10 Gentian Violet Uses + Side Effects & Risks

Gentian Violet: Indications, Side Effects, Warnings – Drugs.com

10 Gentian Violet Uses + Side Effects & Risks

Generic Name: Gentian Violet (JEN shun VYE oh let)

Medically reviewed by Drugs.com. Last updated on Feb 10, 2020.

Uses of Gentian Violet:

  • It is used to help lower the chance of infection from minor cuts, scrapes, burns, or insect bites.

What do I need to tell my doctor BEFORE I take Gentian Violet?

  • If you are allergic to gentian violet; any part of gentian violet; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.

This medicine may interact with other drugs or health problems.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take gentian violet with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Gentian Violet?

  • Tell all of your health care providers that you take gentian violet. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not put on open or deep wounds, animal bites, or severe burns.
  • This medicine may stain clothing or skin.
  • This medicine may cause harm if swallowed. If gentian violet is swallowed, call a doctor or poison control center right away.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

How is this medicine (Gentian Violet) best taken?

Use gentian violet as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Use as you have been told, even if your signs get better.
  • Do not take gentian violet by mouth. Use on your skin only. Keep your mouth, nose, and eyes (may burn).
  • Wash your hands before and after use. Do not wash your hands after use if putting this on your hand.
  • Clean affected part before use. Make sure to dry well.
  • Put a thin layer on the affected part.
  • If putting on with a cotton swab, put on affected part as your doctor or the label tells you.
  • Do not use coverings (bandages, dressings) unless told to do so by the doctor.

What do I do if I miss a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses at the same time or extra doses.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

What are some other side effects of Gentian Violet?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at https://www.fda.gov/medwatch.

If OVERDOSE is suspected:

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Gentian Violet?

  • Store at room temperature.
  • Keep all drugs in a safe place. Keep all drugs the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

Consumer information use

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about gentian violet, please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

  • Oral Thrush
  • Fungal Infection Prophylaxis

Source: https://www.drugs.com/cdi/gentian-violet.html

Flucanazole (diflucan)

10 Gentian Violet Uses + Side Effects & Risks

Fluconazole (Diflucan™) is a synthetic antifungal agent that can be used for the treatment of Candida albicans and other fungal infections.

For the breastfeeding mother in particular, it can be used after other first interventions to treat recurrent Candida infections of the nipples, and, if such a thing exists, as I believe it does, Candida infections of the breasts.

If a mother has sore nipples, the nipples must be treated aggressively first and then is fluconazole (Diflucan) added if nipple treatment alone is unsuccessful.

Candida (yeast) infections of the nipple and ducts

Candida infections of the nipples may occur any time while the mother is breastfeeding. Candida albicans s warm, moist, dark areas. It normally lives on our skin and other areas, and 90% of babies are colonized by it within a few hours of birth. It, many other germs that live on us normally, only becomes a problem under certain circumstances.

Candida infections of the skin or mucous membranes are more ly to occur when there is a breakdown in the integrity of the skin or mucous membrane—one of the reasons why a good latch is very important from the very first day.

Many Candida infections would, perhaps, not have occurred if the mother had not had sore nipples and a breakdown of the skin of the nipples and areola.

The oozing of liquid that occurs often from cracked nipples encourages Candida albicans to change from its harmless form to an invasive form.

The widespread use of antibiotics also encourages the overgrowth of Candida albicans. Many pregnant women, women in labour, and new mothers, as well as their babies receive antibiotics, sometimes with very little justification.

Diagnosis of Candida infections of the nipples and/or ducts

There is no good test which helps makes the diagnosis. A positive culture from the nipple(s) does not prove your pain is due to Candida. Neither does a negative culture mean your pain is not due to Candida. The best way to make a diagnosis is by getting a good history.

Diagnosing the presence or absence of a Candida infection in the baby is not helpful. A baby may have thrush all over his mouth, but the mother may have no pain. A mother may have the classic symptoms of a Candida infection of the nipples, and the baby may have no thrush or diaper rash.

The Typical Symptoms of a Candida Infection of The Nipples Are:

  • Nipple pain that begins after a period of pain-free nursing. Though there are a few other causes of nipple pain that begin later, Candida infection is definitely the most common. The nipple pain of Candida may begin without an interval of pain-free nursing, however.
  • Burning nipple pain that continues throughout the feeding, sometimes continuing after the feeding is over, sometimes beginning in the middle of a feeding as baby is still drinking well.
  • Pain in the breast that is “shooting” or “burning” in nature and which goes through to the mother’s back and shoulder. This pain is usually worse toward the end of the feeding, and worsens still more after the feeding is over. It also tends to be much worse at night. This pain may occur without any nipple pain.

Treating Candida Infections of the Nipples

Our first approach to treating these infections is to apply the All Purpose Nipple Ointment (APNO) (see information sheet APNO).

Next, the mother can add topical Grapefruit Seed Extract and/or Gentian Violet (information sheets Gentian Violet and Candida Protocol) if the ointment alone does not work.

This approach is safe, works rapidly, and almost always, though there seems to have been a decrease in the effectiveness of gentian violet over the past few years. For this reason, we now use the combination of the ointment and the gentian violet as well as the grapefruit seed extract.

A good response to gentian violet confirms that the mother’s nipple pain is caused by Candida since little else will respond to gentian violet. It thus also justifies the use of fluconazole, if needed.

Even if the above treatment does not help, fluconazole should not be used alone to treat sore nipples and should be added to treatment on the nipples, not used instead. I have not found nystatin to be particularly useful either in treatment of the baby’s mouth or in the treatment of the mother’s nipples. Clotrimazole cream alone is also not particularly effective in my opinion, but others obviously feel differently.

Fluconazole for Breast Pain or Very Resistant Nipple Pain

Fluconazole is an antifungal agent that is taken systemically (by mouth or intravenously). It stops fungi (such as Candida albicans) from multiplying, but does not actually kill them. This accounts for the fact that sometimes it takes several days to have an effect. Fluconazole powder is also available and can be mixed with the all purpose nipple ointment instead of miconazole powder.

Fluconazole tends to work best when used in conjunction with probiotics and oral grapefruit seed extract.

Side Effects

Fluconazole is generally well tolerated, but there is no such thing as a drug that never has side effects.

Concern about liver injury is exaggerated, since this complication seems quite rare, usually occurs in people who are taking other medications as well, and who have taken fluconazole for months or longer, and who have immune deficiencies. But it is a possibility that needs to be kept in mind and if it does occur, it can be serious.

Vomiting, diarrhea, abdominal pain and skin rashes are the most common side effects. These are not usually severe, and only occasionally is it necessary to stop the medication because of these side effects. Allergic reactions are possible but uncommon. Call or email immediately if you have any concerns.

Fluconazole in the milk

Fluconazole does appear in the milk, and this is as it should be, since the idea is to treat infection in the breasts and nipples. It is thus superior to ketoconazole, which gets into the milk in only tiny amounts.

The baby will obviously get some, but this drug is now being promoted for use in babies for the treatment of simple thrush. There have been no complications in the baby reported from exposure to fluconazole in the breastmilk.

Continue breastfeeding while taking fluconazole, even if you are told that you should stop.

Dose of fluconazole

Candida albicans is learning to become resistant to fluconazole, and the dose we use has increased over the past few years. Only a few years ago, 100 mg daily for 10 days cured 90% of women of their symptoms.

We have now found this to be inadequate. For resistant cases, a newer antifungal agent, itraconazole, can be used, though it may not be the answer either as it does not have a very powerful effect against Candida.

Your prescription will be for fluconazole 400 mg as a first dose, followed by 100 mg twice daily until you are pain free for a full week, which usually means at least two weeks. This seems, on the basis of our experience, a fairly good guarantee against relapse.

If you have nipple pain continue with the “all purpose nipple ointment” (± gentian violet and grapefruit seed extract) while you are taking fluconazole. However, this means that although most mothers require only the usual two weeks, some need longer treatment.

Occasionally it may take up to seven to ten days for the pain to even start going away. Call if there is no relief in seven days. If there is no relief in 10 days, none at all, it is very unly fluconazole is going to be of any help.

For very resistant cases we have used 100 mg 3x/day for 1 week.

It is sometimes useful to treat the baby as well. The dose for the baby would be 6 mg/kg as a first dose, followed by 3 mg/kg/day as one dose for the same period of time as the mother.

Preferable is to treat the baby first with probiotics by mouth (see Information Sheet Candida Protocol). This is easy to do and fairly inexpensive.

A small amount of probiotic powder placed on mother’s wet finger so baby will suck on it for a few seconds before a feeding 2x/day for 4-7 days is often adequate treatment for the baby with thrush.

Note: The mother’s two week prescription is ly to cost between $300 and $350, though there is now a generic fluconazole available which is less expensive.

Written and Revised by Jack Newman, MD, FRCPC, 2009©
Revised by Edith Kernerman, IBCLC, 2009©

Source: https://www.canadianbreastfeedingfoundation.org/basics/fluconazole.shtml

Thrush Medication: Antifungal agents

10 Gentian Violet Uses + Side Effects & Risks

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Source: https://emedicine.medscape.com/article/969147-medication

Candidiasis (thrush, yeast infection)

10 Gentian Violet Uses + Side Effects & Risks

Thrush, also called candidiasis, is a disease caused by the fungus, Candida albicans. Everyone has this fungus: It can be found on the skin, in the stomach, colon, rectum, vagina, and in the mouth and throat. Most of the time, it is harmless and actually helps keeps bacteria under control. Sometimes, however, the fungus overgrows which can lead to various problems.

People living with and without HIV can develop candidiasis, including women who develop vaginal yeast infections—a type of candidiasis. A person could also experience an overgrowth of fungus in their mouth or the back of their throat. Stress, poor diet, or not getting enough rest can contribute to these problems.

Also, using antibiotics—especially over long periods of time—can cause the infection to develop in the mouth or vagina. Oral thrush can also occur in people who use inhaled steroids, such as those for treating asthma and other lung problems.

Poor oral hygiene and smoking can also play a role in thrush. Excessive alcohol and sugar consumption have also been linked to it.

In people living with HIV, oral thrush and vaginal yeast infections can occur at any time, regardless of CD4 counts. The more the immune system weakens, the more ly these infections will occur and recur more often.

People living with HIV who have a CD4 count below 200 are also more ly to develop candidiasis deeper in their bodies, such as in the esophagus or lungs.

As with many opportunistic infections, candidiasis will usually improve or recur less often if HIV treatment significantly increases CD4 counts.

What are the symptoms?

Symptoms depend on the part of the body that’s affected. If you have any of these symptoms, you should contact your doctor:

  • Oral candidiasis: Symptoms include burning pain in the mouth or throat, altered taste (especially when eating spicy or sweet foods), and difficulty swallowing. It appears as white or pinkish-red blotches on the tongue, gums, the sides or roof of the mouth, and the back of the throat. Sometimes, thrush can cause the corners of the mouth to become chapped, cracked, and sore.
  • Vaginal candidiasis: The most obvious symptom is a thick white discharge resembling cottage cheese. It can also cause itching and burning in or around the vagina, as well as a rash and tenderness of the outer lips of the vagina (labia). Women living with HIV are more ly to experience recurrent vaginal candidiasis than women who are HIV negative.
  • Esophageal candidiasis: This type of candidiasis occurs deep down in the throat and can’t always be seen by looking into the mouth. It can cause chest pain, as well as pain and difficulty when swallowing. This is much more common in people with HIV with lower CD4 counts.

How is candidiasis diagnosed?

Most of the time, a doctor can diagnose candidiasis simply by looking in the mouth, at the back of the throat, or in the vagina.

Sometimes it is necessary to scrape the overgrowth so that a sample can be sent to a lab.

Assessing symptoms, X-rays and a special flexible microscope called an endoscope are used to look for candidiasis in the throat. People with thrush should be checked for possible esophageal disease as well.

How is candidiasis treated?

Just as there are three different types of candidiasis, there are three somewhat different ways to treat the disease.

Treatment for Oral Candidiasis

The most common treatment is to use a medicated liquid that is swished around the mouth and swallowed or to suck on a lozenge until it dissolves and then swallow. However, oral pills (not to be used during pregnancy) are just as or more effective than these other forms and offer more convenient dosing. The CDC recommends:

  • Fluconazole (Diflucan tablets): Diflucan is a tablet that must be swallowed. Studies show that it is just as effective as clotrimazole and nystatin, but is more convenient and better tolerated. The dose is typically 100 mg a day for 7–14 days.

Other treatments include:

  • Miconazole (Oravig): This 50 mg oral tablet is applied to the upper gum once a day for 1–2 weeks. Tablets should not be chewed or swallowed.
  • Clotrimazole (Mycelex trouches): These lozenges are used five times a day for 1–2 weeks. Lozenges should dissolve in the mouth slowly and should not be chewed or swallowed whole. Clotrimazole can upset the stomach.
  • Nystatin (Mycostatin liquid or pastilles): Nystatin is available as a liquid or lozenge. The liquid dose is 5 milliliters taken four times a day for 1–2 weeks. It should be swished around the mouth slowly for a few minutes and then swallowed. One or two lozenges are taken four times a day for 7–14 days. They should dissolve in the mouth slowly and should not be chewed or swallowed whole.
  • Itraconazole (Sporanox liquid suspension): This liquid must be swallowed. While it is as effective as the four medications listed above, it is not as well tolerated as fluconazole tablets.
  • Posaconazole oral suspension (Noxafil): This is as effective as fluconazole, but has more interactions with other drugs similar to itraconazole. The liquid should be taken with food and is used once a day, swished around the mouth slowly for several minutes and then swallowed.
  • Another possible treatment for thrush is gentian violet (Genapax).This is a dye made from coal tar and can be purchased from some pharmacies, health food stores, and other places where supplemental therapies are sold. Gentian violet is very messy and can stain clothing. It can also stain the inside of the mouth, which fades over time. It should be handled with care. For oral thrush, apply the dye by using a cotton swab. Dip the swab in the dye and coat the spots of Candida in the mouth. Avoid swallowing the drug as it can upset the stomach.

Treatment for Vaginal Candidiasis

The most common treatments are medicated creams or inserts (suppository) placed into the vagina. Most are available over-the-counter in many drug stores. However, these products can weaken condoms and diaphragms, which can increase the risk of pregnancy and HIV transmission.

  • Fluconazole (Diflucan): One 150 mg dose of this tablet is taken for uncomplicated candidiasis. It should not be used during pregnancy.
  • Topical drugs: These include a range of creams, ointments or suppositories. Some are used for as little as three days to up to 14 days. Many are found over the counter while others are by available by prescription. Discuss with your health provider which are best for you to use. They include the following:
    • Butoconazole (Femstat cream)
    • Clotrimazole (Gyne-Lotrimin cream)
    • Clotrimazole (Mycelex vaginal suppositories)
    • Miconazole (Monistat vaginal cream)
    • Miconazole (Monistat vaginal suppositories)
    • Terconazole (Terazol 3 and Terazol 7 creams)
    • Terconazole (Terazol 3 suppositories)
    • Tioconazole (Vagistat ointment)
  • Itraconazole (Sporanox oral solution): The 200 mg dose is taken once a daily for 3–7 days as an alternative to fluconazole.

As with thrush, if vaginal yeast infections do not go away while using these creams or suppositories, or if the infection returns soon after treatment is stopped, more potent drugs such as nystatin (Mycostatin) liquid, itraconazole (Sporanox) liquid, or fluconazole (Diflucan) tablets can be prescribed by a doctor. Women who are pregnant should not use these oral drugs as they may harm the developing fetus.

Another possible treatment for vaginal yeast infections is gentian violet (Genapax). (See above for more information.) Genapax can be purchased as a tampon, and each contains 5 mg of gentian violet. The tampons can be messy and can stain clothing and undergarments. Handle and insert with care. Gentian violet tampons are inserted once or twice a day for 1–2 weeks.

Treatment for Esophageal Candidiasis

Because esophageal candidiasis is considered to be more severe, deeper in the body, and harder to treat, higher doses of drugs than those used to treat oral or vaginal candidiasis are usually needed to treat it. These drugs can cause liver enzymes to increase.

They can also interact with other medications, including protease inhibitors, non-nucleoside reverse transcriptase inhibitors, as well as certain antihistamines and sedatives.

Be sure to check with your doctor about other drugs you are taking before taking these antifungal treatments.

  • Fluconazole (Diflucan): An intravenous solution or 200 mg tablet of fluconazole is taken once a day for 2–3 weeks. Fluconazole is considered the first choice for treatment.
  • Itraconazole (Sporanox oral solution): This liquid should be taken on an empty stomach and vigorously swished around the mouth for several seconds and then swallowed. It is taken once a day for 2–3 weeks.
  • Other antifungals: Several other drugs can be used for 2–3 weeks, including voriconazole, isavuconazole, caspofungin, micafungin, anidulafungin, and amphotericin B.

Treatment for Severe or Drug-Resistant Candidiasis

Sometimes, candidiasis can become resistant to the “azole” drugs (all of those listed above) or is so severe that it cannot be adequately treated using any of these treatments. As a result, a drug called amphotericin B is often used. It is usually given by IV in a hospital. The two types are standard amphotericin B (Fungizone) and liposomal amphotericin B (Abelcet, AmBisome, Amphotec).

Amphotericin B can cause serious side effects, including kidney damage, allergic reactions (fever, chills, altered blood pressure, etc.), bone marrow damage, nausea, vomiting and headache.

The risk of kidney damage is increased if amphotericin B is taken with cidofovir (Vistide) or ganciclovir (Cytovene), two drugs used to treat CMV, and pentamidine (NebuPent), a drug used to treat PCP.

The risk of bone marrow damage is increased if amphotericin B is taken at the same time as AZT (Retrovir), flucytosine (Ancobon) or ganciclovir.

Generally speaking, liposomal amphotericin B is less toxic than standard amphotericin B. However, standard amphotericin B is faster acting and is usually the drug of choice when infections are severe and an immediate threat to life.

How should pregnant women be treated for candidiasis?

Because many antifungal drugs can be toxic to a developing fetus, the CDC recommends that topical treatments—such as creams or suppositories for vaginal candidiasis—be used whenever possible.

Can candidiasis be prevented?

There is no guaranteed way to prevent infection with the fungus or to prevent developing oral thrush, vaginal yeast infections, or more serious forms of candidiasis.

These infections are more ly to occur in people with CD4 counts below 200.

Thus, one way to help prevent it from occurring is to keep the immune system healthy—by taking HIV medications, reducing stress, eating right and getting plenty of rest.

There is still some debate regarding the use of antifungal drugs to prevent candidiasis. A few studies show that fluconazole can reduce the number of infections. However, it may be possible that prolonged use of fluconazole—or any “azole” drug—may lead to the fungus becoming resistant.

This can prevent the drugs from working correctly when they are most needed. Because of this, many doctors do not recommend using these drugs continuously to prevent candidiasis.

However, this may be the best option for people with a history of frequent outbreaks of oral thrush or vaginal infections.

There are some tips to help prevent candidiasis:

  • Watch your diet: It may be helpful to avoid foods high in sugar, dairy, yeast, wheat and caffeine. These are believed to promote fungal overgrowth.
  • Eat yogurt: Many experts also recommend eating lots of yogurt that contains Lactobacillus acidophilus, a “good” bacteria believed to keep Candida albicans under control. Be sure the yogurt packaging reads “contains Lactobacillus acidophilus.”
  • Practice good oral hygiene: This includes brushing regularly, flossing, using an antiseptic mouthwash (Listerine, etc.), and reducing/eliminating the use of tobacco products such as chewing tobacco and cigarettes.
  • For vaginal yeast infections: To help reduce the risk of vaginal infections, wear loose, natural-fiber clothing and undergarments with a cotton crotch. Also, stay away from deodorant tampons and feminine deodorant sprays.

Are there any experimental treatments?

Candidiasis is a problem for many people, regardless of whether or not they have HIV. This is especially true for people who have strains of Candida that are resistant to currently available drugs. Thus, new drugs are always being developed for candidiasis and other fungal infections.

If you would to find out if you are eligible for any clinical trials involving new treatments for candidiasis, visit ClinicalTrials.gov, a site run by the U.S. National Institutes of Health.

The site has information about all HIV-related clinical studies in the United States. For more info, you can call their toll-free number at 1-800-HIV-0440 (1-800-448-0440) or email contactus@aidsinfo.


Last Reviewed: January 24, 2019

    Read More About:
  • #oral health
  • #thrush
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Source: https://www.poz.com/basics/hiv-basics/candidiasis-thrush-yeast-infection

Gentian Violet | Drug Information, Uses, Side Effects, Chemistry

10 Gentian Violet Uses + Side Effects & Risks

4 Drug and Medication Information

4.1 Therapeutic Uses

Anti-Infective Agents, Local; Antinematodal Agents; Rosaniline Dyes

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

Gentian violet has been used in medicine for almost 100 years: as an antiseptic for external use, as an antihelminthic agent by oral administration, and more recently, as a blood additive to prevent transmission of Chagas' disease. …

Docampo R, Moreno SN; Drug Metab Rev 22 (2-3): 161-78 (1990)

THERAPEUTIC CATEGORY: Anti-infective (topical). Has been used as anthelmintic (Nematodes), Blood additive to prevent transmission of Chagas disease by blood transfusion

O'Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 757

THERAPEUTIC CATEGORY (VET): Anti-infective (topical); mycostatic agent in poultry feed

O'Neil, M.J. (ed.). The Merck Index – An Encyclopedia of Chemicals, Drugs, and Biologicals. Whitehouse Station, NJ: Merck and Co., Inc., 2006., p. 757

…Acts against the causative organism of Vincent's angina & against many strains of Monilia, Torula, Epidermophyton, & Trichophyton. Among the many conditions which have been treated …

cystitis & urethritis, suppurating joint infections, eczematoid dermatitis, furunculosis, recurrent dermatomycosis, chronic ulcers, bed sores, impetigo, pruritus ani, leukorrhea & vaginitis, etc.

The drug has been largely outmoded by antibiotics & systemic antibacterial drugs, not so much because of its inefficacy but because of its cosmetic effects & staining of clothing. /Former/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1091

The dye has been employed in the treatment of burns. This forms a pliable eschar & helps to control infection from gram-positive organisms. However, it is little used today for this purpose. Gentian violet is … an effective anthelmintic useful in the treatment of strongyloides & oxyuris infestations. /Former/

Osol, A. and J.E. Hoover, et al. (eds.). Remington's Pharmaceutical Sciences. 15th ed. Easton, Pennsylvania: Mack Publishing Co., 1975., p. 1091

Gentian violet is bacteriostatic & bactericidal to gram-positive bacteria & to many fungi. Gram-negative & acid-fast bacteria are very resistant to the drug. Once widely employed in the control of many types of infections.

It has been used for superficial pyogenic infections, impetigo, Vincent's infection, & chronic & irritative lesions & dermatitides. It is still occasionally employed in treatment of fungal infections. For direct application to tissues, the dye is used in concentrations of 0.02% to 1%.

Vaginal suppositories contain 17 mg, while vaginal tablets contain 2 mg. For instillations in closed cavities, the concentration is reduced to 0.01%. /Former/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 979

4.2 Drug Warning

Permanent pigmentation of the skin can result from contact of gentian violet with granulation tissue, & the dye should not be applied to ulcerative lesions of the face. The staining properties are a distinct disadvantage.

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 979

Oral ulceration developed in 6 neonates who were treated for oral candidiasis with gentian (crystal) violet. A 0.5 or 1% aq soln was used and applications were made twice daily.


4.3 Minimum/Potential Fatal Human Dose

Source: https://www.pharmacompass.com/chemistry-chemical-name/gentian-violet

Yeast Infections

10 Gentian Violet Uses + Side Effects & Risks

Candida albicans, a yeast fungus often called simply candida, grows in the rectum and vagina. It grows best in a mildly acidic environment. The pH in the vagina is normally more than mildly acidic.

However, when we menstruate, take birth control pills or some antibiotics, are pregnant, or have diabetes, the pH becomes more alkaline. In a healthy vagina, the presence of some yeast may not be a problem.

When our system is balance, yeast- organisms can grow profusely and cause a thick white discharge that may look cottage cheese and smell baking bread.

Sometimes this causes intense itching while at other times it just causes intermittent burning or a sense of irritation.

One study about the risk of recurring yeast infections found that sexual behaviors, rather than the presence of candida fungus on the male partner, were associated with recurrences.

Women who had not had candida infections in the vulvovaginal area during the previous year were able to masturbate with saliva without increasing their risk of a candida infection, whereas women with a recent history of such infection in the vulvovaginal area increased the lihood of a recurrent infection if they masturbated with saliva.


The only way to be sure that an infection is caused by candida and not something else is to have vaginal secretions analyzed under a microscope. In some cases, it helps to get a lab culture done.

Other conditions causing vaginal irritation may respond temporarily to treatment for candida and then recur a short time later, so accurate diagnosis is important.

Self-diagnosis is inaccurate more than half the time, so hold off from self-treatment until diagnosis by a healthcare provider.

Medical Treatments for Yeast Infections

Treatment usually consists of some form of vaginal suppository or cream or an oral antifungal. The former is available over the counter, while pills require a prescription.

Antifungal external creams such as clotrimazole may reduce or even eliminate the symptoms, sometimes without actually curing the infection. A small percent of women have recurrent or chronic yeast infections.

Prolonged oral treatment is sometimes required but should be a yeast culture.

Suppositories and creams have fewer side effects than oral medications, and they can be used during pregnancy. If a woman has a yeast infection when she gives birth, the baby will be ly to get yeast in its throat or digestive tract. This is called thrush and is treated orally with nystatin drops.

Other treatments for candida infection involve boric acid capsules or painting the vagina, cervix, and vulva with gentian violet. The latter is bright purple and stains, so a sanitary pad must be worn. This procedure can help, but in occasional cases, women have a severe reaction to gentian violet.

Side effects are rare with boric acid, but it may cause vaginal burning and itching. Do not use boric acid near any cuts or abrasions, as it can enter the bloodstream and may cause nausea, vomiting, diarrhea, dermatitis, and kidney damage. Boric acid is never taken orally and is typically used only after other FDA-approved treatments have failed.


Some women have had success with the following remedies: acidifying the system by drinking eight ounces of unsweetened cranberry juice every day, or taking cranberry concentrate supplements; inserting plain, unsweetened, live-culture yogurt in the vagina; inserting garlic suppositories (to prevent irritation, peel but don’t nick a clove of garlic, then wrap in gauze before inserting). But there is no good research on whether these home remedies are effective.

Since yeast thrive on sugar, it may be helpful to reduce the amount of sugar in your diet. Avoid douches and don’t use tampons for your period when you have an infection. If you have a male sex partner, have him apply antifungal cream to his penis twice a day for two weeks, especially if he’s not circumcised.

Source: https://www.ourbodiesourselves.org/book-excerpts/health-article/yeast-infections/

Using Gentian Violet

10 Gentian Violet Uses + Side Effects & Risks

Gentian violet (1% solution in water) is an excellent treatment for Candida albicans. Candida albicans is a yeast which may cause an infection of skin and/or mucous membranes in both children and adults.

In small children, this yeast may cause white patches in the mouth (thrush), or diaper rash. When the nursing mother has a yeast infection of the nipple, she may experience severe nipple pain, as well as deep breast pain.

Nipple pain caused by Candida albicans

The pain caused by a yeast infection is generally different from the pain caused by poor positioning and/or ineffective suckling. The pain caused by a yeast infection:

1. is often burning in nature, rather than the sharp, stabbing or pinching pain associated with other causes. Burning pain may be due to other causes, however, and pain due to a yeast infection does not necessarily burn.

2. frequently lasts throughout the feeding, and occasionally continues after the feeding has ended. This is in contrast to the pain due to other causes which usually hurts most as feeding begins, and gradually improves as the baby nurses.

3. may radiate into the mother's armpit or into her back.

4. may cause no change in appearance of the mother's nipples or areolas, though there may be redness, or some scaling, or the skin of the areola may be smooth and shiny.

5. not uncommonly will begin after a period of pain free nursing. This characteristic alone is reason enough to try treatment for yeast. However, milk blisters on the nipple also may cause nipple pain after a period of pain free nursing.

6. may be associated with recent use of antibiotics by the baby or mother, but not necessarily.

7. may be quite severe, may or may not be itchy.

8. may occur only in the breast. This pain is often described as “shooting”, or “burning” in nature, and is often worse after the feeding is over. It is often said to be worse at night. At the same time, the breast appears or feels normal. This is not mastitis and there is no reason to treat with antibiotics. On the contrary, antibiotics may make the problem worse.

Please Note:

a) The baby does not have to have thrush in his mouth.

b) A yeast infection of the nipple may be combined with other causes of soreness.

Using Gentian Violet

We believe that gentian violet is the best treatment of nipple soreness due to Candida albicans for the breastfeeding mother. This is because it works almost always, and relief is rapid.

It is messy, and will stain clothing, but not skin. The baby's lips will turn purple, but the purple will disappear after a few days. Gentian violet is available without prescription but is not available at all pharmacies.

Call around before going out to get it.

1) About 10 ml (two teaspoons) of gentian violet is more than enough for an entire treatment.

2) Many mothers prefer doing the treatment just before bed so that they can keep their nipples exposed and not worry about staining their clothing. The baby should be undressed to his diaper, and the mother should be uncovered from the waist up. Gentian violet is messy.

3) Dip an ear swab (Q-tip) into the gentian violet.

4) Put the purple end of the ear swab into the baby's mouth and let him suck on the swab for a few seconds. The gentian violet usually spreads around the mouth quickly. If it does not, paint the inside of the mouth to cover as much of the inside of the cheeks and tongue as possible.

5) Put the baby to the breast. In this way, both the baby's mouth and your nipple are treated.

6) If, at the end of the feeding, you have a baby with a purple mouth, and two purple nipples, there is nothing more to do. If only one nipple is purple, paint the other one with the ear swab and the gentian violet. In this way, the treatment is finished in one go.

7) Repeat the treatment each day for three or four days.

8) There is often some relief within hours of the first treatment, and the pain is usually gone or virtually gone by the third day.

If it is not, it is unly that Candida was the problem, though it seems Candida albicans is starting to show some resistance to gentian violet, as it is to other antifungal agents.

Of course there may be more than one cause of nipple pain, but after three days the contribution to your pain caused by Candida albicans should be gone. Do not continue the gentian violet if no relief occurs after 3-4 days of treatment. Instead, get more information.

9) All artificial nipples that the baby uses should be boiled daily during the treatment, or well covered with gentian violet. Consider stopping artificial nipples.

10)There is no need to treat just because the baby has thrush in his mouth. The reason to treat is the mother's and/or the baby's discomfort. Babies, however, do not commonly seem to be bothered by thrush.

11)Uncommonly, babies who are treated with gentian violet develop sores in the mouth which may cause them to reject the breast. If this occurs, or if the baby is irritable while nursing, stop the gentian violet immediately, and contact the clinic. The sores clear up within 24 hours and the baby returns to feeding.

If the infection recurs, treatment can be repeated as above. But if the infection recurs a third time, a source of reinfection should be sought out.

The source may be the mother who may be a carrier for the yeast (but may have no sign of infection elsewhere), or from artificial nipples the baby puts in his mouth.

Treatment of the mother (usually with a medication other than gentian violet) at the same time as treatment is repeated for the nipples will usually eliminate reinfection. Contact the clinic.

Handout #6. Using Gentian Violet Revised January 1998

About the Author:

JACK NEWMAN, MD, FRCPC is a pediatrician, a graduate of the University of Toronto medical school. He started the first hospital-based breastfeeding clinic in Canada in 1984. He has been a consultant with UNICEF for the Baby Friendly Hospital Initiative in Africa. Dr. Newman has practiced as a physician in Canada, New Zealand, and South Africa.

Source: https://www.obgyn.net/pregnancy-and-birth/using-gentian-violet