- Pramiracetam Review – Its Effects, Dosage, Benefits, and Risks
- How Does Pramiracetam Work?
- Is Pramiracetam Safe to Use?
- How Should You Use Pramiracetam?
- Final Thoughts
- What Do We Know About Pramiracetam? Potential Effects, Dosage & More
- What is Pramiracetam?
- Mechanism of Action
- Purported Uses of Pramiracetam
- 1)May Affect Memory
- 2)May Be “Neuro-Protective”
- 3)May Affect Recovery from Brain Injuries
- Pramiracetam Side-Effects
- Dosage of Pramiracetam
- Limitations and Caveats
- Pramiracetam: Nootropic Benefits, Effects, Dosage, and More
- Cognitive Enhancement
- Pramiracetam vs Piracetam
- Pramiracetam Benefits, Dosage, Stacking and Side Effects
- Pramiracetam Benefits and Effects
- How Pramiracetam Works
- Pramiracetam Dosage
- Pramiracetam Stacks
- Choline Stacks
- Armodafinil, Modafinil, or Adrafinil
- Pramiracetam Side Effects
- My Experience with Pramiracetam
- Where to Buy Pramiracetam
- Benefits and Effects of Pramiracetam
- Improved Memory
- Increased Alertness and Expanded Learning Capacity
- Dementia Treatment
- Social Fluency
- Neuroprotective Capabilities
- How It Works
- Pramiracetam and Oxiracetam Stack
- Pramiracetam and Aniracetam Stack
- Side Effects
- Where to Buy
- Closing Thoughts
Pramiracetam Review – Its Effects, Dosage, Benefits, and Risks
Pramiracetam is not a new drug. In fact, it was first invented under the name Pramistar back in the 1970's!
But un others in its class of racetam nootropics, Pramiracetam has had a long journey to find its place and purpose in the greater treatment lexicon.
As well, Pramiracetam is just now attracting more interest among the general public for the many cognitive enhancing benefits it has to offer.
In this article, learn more about the history of Pramiracetam, its major uses, dosing suggestions and how it works to boost memory, learning, focus and productivity, among other benefits.
Pramiracetam is actually the next generation version of piracetam, the original racetam nootropic that was developed for use in the Russian space program.
The most significant difference between piracetam and pramiracetam is the strength.
As this user review video highlights, pramiracetam is significantly stronger than not just piracetam, but potentially all other racetam nootropics.
The reason behind the increased potency is a substitution in the formula. With the substitution of dipropan-2-ylamino ethyl for amides, pramiracetam's potency gets a noticeable boost.
In one study published by the Behavior and Brain Research Journal, laboratory rats required 13 times the dose of piracetam to match the cognitive response to a single dose of pramiracetam.
How Does Pramiracetam Work?
Unless you have a background in chemistry and pharmacology, you may not be fully clear on what is meant by a “racetam nootropic.” Below you will see how we define each term:
The term “racetam” denotes a class of drugs that shares a common nucleus made of pyrrolidone. Pyrrolidone is a synthetic organic compound.
While each racetam shares the same nucleic structure, this doesn't mean they all work the same way. For example, both piracetam and pramiracetam share a pyrrolidone-based nucleus. Yet the latter is far stronger than the former.
The easiest translation of the word “nootropic” is smart drug.
The term smart drug indicates a drug has the potential to enhance cognitive function, whether through focus, memory, productivity, motivation, creativity and other cognitive performance markers.
Pramiracetam is a racetam nootropic. This means pramiracetam is a synthetically-derived organic drug that impacts cognitive ability.
Now that you have a basic working knowledge of what a racetam nootropic actually is, let's take a look at the specific way that pramiracetam works to positively impact cognitive ability.
In studies using laboratory rats, researchers learned that application of pramiracetam increased Acetylcholine uptake in the rats' brains up to 37 percent. As well, nitric oxide, another component of learning and memory, was also increased after dosing.
Along with nitric oxide's known memory and learning-enhancement impact, this is significant because acetylcholine is a type of neurotransmitter that is specifically linked to the cognitive functions of memory and learning.
From this, researchers concluded that pramiracetam can help to enhance memory and aid in learning.
Additional research studies showed that pramiracetam can convey protective properties against amnesia and may even be able to help reverse amnesia after brain trauma or injury.
A Russian research study showed that pramiracetam is able to help reduce side effects of brain trauma and concussion.
A number of additional similar research studies showed that memory loss caused by reduced cranial blood flow, brain injury and concussion could potentially be reversed by application of pramiracetam.
Is Pramiracetam Safe to Use?
While pramiracetam is not currently regulated by the Food and Drug Administration (FDA) and is available without a prescription in the United States, this does not mean you should not treat it as a serious drug in its own right.
Numerous research studies point to the impact all racetam nootropic drugs have on cognitive function – and pramiracetam may well be the most potent drug in this class.
It is important to talk with your health provider if you are under a doctor's care for the management of any serious health condition or are on any medications on an ongoing basis.
You should always start with the lowest dose recommended by your provider or the manufacturer and see how your body responds before increasing the dosage. It is also important to take it earlier in the day to avoid any sleep disruption.
No studies to date have shown that pramiracetam has any significant concerning side effects. The most commonly reported temporary side effects of taking pramiracetam include headache, nausea, throat burning and insomnia.
Taking pramiracetam earlier in the day is the best way to sidestep any issues with sleep disturbance or insomnia. This makes sense since pramiracetam's primary impact is to enhance cognitive performance by stimulating brain activity!
If you are currently pregnant, trying to conceive or lactating, always talk with your doctor before adding anything new to your daily health and wellness routine.
How Should You Use Pramiracetam?
Pramiracetam is available as a powder, tablet or capsule. Many users report that the powder is extremely bitter and the taste can be unpleasant even when added to smoothies. If you are very taste-sensitive, you may prefer the tablet or capsule form.
Of the three, studies show that the powder and the capsule forms have the fastest absorption rates, but ultimately all three deliver the same potency.
Studies with laboratory rats show that the benefits of taking pramiracetam may be enhanced when taken together with choline.
For this reason, it is not uncommon to find pramiracetam combined with a choline supplement in order to boost the overall effect of taking pramiracetam.
The most common starting dose is 1,200 mg divided up into two or three different doses throughout the day. So you may want to do 600 mg in the morning and 600 mg at lunchtime or 400 mg in the morning, 400 mg at lunchtime and 400 mg in mid-afternoon.
In order to avoid any sleep disruption, it is best not to take pramiracetam any later than mid-afternoon.
It is also important to take pramiracetam with food and to include some fat with your meal to enhance absorption and benefits.
Now that you understand more about the history of pramiracetam, how it is designed to work and common dosing patterns, let's take a closer look at the specific benefits of taking pramiracetam.
Improve Short-term and Long-term Memory
Pramiracetam has been shown to improve memory by stimulating activity in the hippocampus, the area in the brain that bears primary responsibility to create, encode and store memories.
In this way, pramiracetam impedes forgetfulness, improves recall and ensures that memories are both made and stored properly.
Un with some racetam nootropics that are primarily beneficial for healing after trauma, pramiracetam has shown this ability both in healthy individuals and in patients who are recovering from brain injuries.
Facilitate Recovery from Brain Trauma and Injuries
Brain injury and trauma can produce a number of difficult side effects, including memory loss/amnesia, dizziness, nausea, headaches and disorientation.
In a research study published by the Journal of Brain Injuries, human participants with brain injuries who received treatment with pramiracetam over a six-week period showed marked improvement in all symptoms.
A similar research study published in a Russian research journal showed that memory impairment caused by diminished blood flow to the brain could be at least partially remedied by dosing with pramiracetam.
Increase Mental Focus and Alertness
Neuroplasticity, the ability of the brain to create new neural connections throughout life both normally and after injury, is one of the primary mechanisms behind maintaining proper cognitive function.
Studies involving laboratory animals show that dosing with pramiracetam increase the ability of neurons to both synthesize nitric oxide and increase production of choline, both important in the formation and encoding of new memories.
Reverse the Impact of Dementia
As the human population continues to age and lifespans continue to increase, there is an increased focus on finding effective, immediately impactful treatments for disease of cognitive impairment such as Alzheimer's and dementia.
Because of Pramiracetam's known benefit in reversing amnesia and aiding in memory encoding and storage, this makes pramiracetam a treatment of increasing interest for age-related cognitive decline.
Boost Sensory Perception
“Sensory perception” is a term that encompasses both visual and auditory enhancement.
Pramiracetam has a demonstrated impact on both visual and auditory sensory perception, where users report enhanced color and sound benefits after dosing.
Now that you know more about pramiracetam, how it works, how it is used, dosing guidelines and benefits, it is time to decide how you want to receive these benefits for yourself.
Rather than let yourself get overwhelmed by too much information, it can help to simply focus on choosing a single pramiracetam preparation from a trusted manufacturer. Start with the lowest recommended dosage until you see how your body responds.
Before you know it, you can be on your way to experiencing the cognitive benefits or pramiracetam for healing and peak performance.
Mind Lab Pro® is the world's first Universal Nootropic™ – formulated to promote a healthy, peak-performing mindstate known as 100% Brainpower™
Shannon is a freelance writer and author of three books. Shannon is passionate about crafting knowledge-based, science-supported articles that provide readers with practical, actionable tools to make healthy life choices.
Important Disclaimer: The information contained on the Nootropics Review Nerd is intended for informational and educational purposes only.
Any statements made on this website have not been evaluated by the FDA and any information or products discussed are not intended to diagnose, cure, treat or prevent any disease or illness.
Please consult a healthcare practitioner before making changes to your diet or taking supplements that may interfere with medications.
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What Do We Know About Pramiracetam? Potential Effects, Dosage & More
Pramiracetam is a new drug in the “racetam” family of drugs that is widely claimed to have “nootropic” (“cognitive-enhancing”) effects. It is closely related to piracetam, another relatively popular nootropic compound.
Pramiracetam is often claimed to have a number of interesting potential effects on the brain and certain aspects of cognitive functioning – but what does the current science have to say about these effects? Read on to learn more about the potential effects, mechanisms, and side-effects of this drug.
Disclaimer: This post is not a recommendation or endorsement for the use of pramiracetam.
The FDA has not approved this drug for any specific medical or other use, and the available research on it is still in a very early stage, without adequate data to come to any firm conclusions about its general efficacy or safety in humans.
We have written this post for informational purposes only, and our goal is solely to inform people about what science currently says about pramiracetam’s mechanisms, potential effects, and possible side-effects.
What is Pramiracetam?
Pramiracetam – sometimes also known as Pramistar – is a cognitive enhancer (“nootropic”) drug that is synthesized from piracetam, the original drug in the “racetam” family of drugs.
Pramiracetam was developed in 1979 by Parke-Davis, a division of the Warner-Lambert pharmaceutical company. Pramiracetam was at first distributed under the brand name Pramistar. Now, it is part of Pfizer, since Warner-Lambert merged with Pfizer in 2000.
some early animal research in the late 1980s, pramiracetam was reported to have cognitive effects in rats. Additionally, it was also reported to be as much as 13 times more potent (meaning that the researchers observed effects that were equivalent to piracetam with a dose that was only 1/13th the size) .
Unfortunately, many nootropic drugs, pramiracetam has not been extensively studied by scientists, so only a little is known about its potential effects and mechanisms.
Also many nootropic drugs, many interesting claims have been made about this drug’s effects on cognitive ability.
But are these effects backed up by science, or are they just empty hype? In the rest of this post, we’ll discuss what the current science says about this drug, and see if the evidence really backs up all the claims that have been made about it.
Mechanism of Action
all racetams, the mechanisms behind pramiracetam are not fully understood, primarily due to a lack of extensive research.
However, some early studies have pointed towards a few of the following potential mechanisms:
However, data about the above mechanisms comes almost exclusively from animal studies – predominantly in rats and mice – and so no strong conclusions can be made yet about pramiracetam’s potential mechanisms in the brains of healthy human users.
Purported Uses of Pramiracetam
Listed below are some of the effects of pramiracetam that have been reported by preliminary studies so far.
While some of these early results might seem promising, the evidence is still too weak as a whole to come to any definitive conclusions about pramiracetam’s effects on the brain or cognitive ability.
In other words, these purported uses of pramiracetam should be considered as currently having insufficient evidence to support them – and much more research will still be needed to figure out exactly what effects this substance might have in healthy human users.
1) May Affect Memory
One of the most common claims about pramiracetam is that is can boost memory. However, the only studies that speak to this potential effect so far have looked either at animal models, or human patients with specific health conditions.
For example, one pilot study of 35 elderly volunteers with memory loss reported that those who received pramiracetam showed greater improvements in memory than those who received memory training, as well as those who did not receive either .
In another study (double-blind randomized controlled trial) of four young men with brain injury, pramiracetam was reported to improve both short- and long-term memory. This effect supposedly lasted for up to 1 full month after the treatment was discontinued .
Unfortunately, both of these studies have some major limitations. For one, they have only very small sample sizes, and much larger samples will be needed before these effects can be confirmed.
Secondly, the studies only looked at people with specific brain-related health conditions, so it’s not possible to say with certainty whether similar effects would be seen in ordinary healthy users of pramiracetam.
In addition to these inconclusive human studies, there is some preliminary evidence from animal studies as well.
For example, one animal study reported that seven weeks of treatment with pramiracetam may have increased long-term memory and learning ability in rats .
Similarly, another study reported that pramiracetam may have improved object-recognition memory in rats .
2) May Be “Neuro-Protective”
A handful of studies have looked at pramiracetam’s potential to protect the brain from the negative effects of other toxins or drugs.
In one study (double-blind randomized controlled trial) of 24 young and old healthy volunteers, it was reported that pramiracetam partially reduced the memory loss caused by scopolamine, a drug that produces temporary amnesia .
In another study (prospective cohort) of 65 patients with head injuries, pramiracetam reportedly worked better than piracetam at reducing symptoms associated with amnesia .
According to one animal study, pre-treating rats with pramiracetam prevented some of the memory loss caused by substance that causes amnesia (hemicholinium-3) .
Finally, another early animal study reported that pramiracetam may partially prevent some memory loss in mice caused by electric shocks .
All in all, however, the evidence for these effects is still highly inconclusive, and more research will definitely be needed.
3) May Affect Recovery from Brain Injuries
A few studies have also investigated pramiracetam’s potential to help the brain recover from injury or trauma.
According to one preliminary study (prospective cohort) of 65 people with mild brain injury, pramiracetam was reported to reduce headaches, dizziness, and nausea more effectively than piracetam .
Another study (double-blind randomized controlled trial) of four men with severe brain injuries reported that six weeks of pramiracetam supplementation significantly improved their memory compared to an inactive placebo treatment . However, the sample size of this study is very small.
Chronic cerebrovascular insufficiency refers to a number of conditions in which the arteries supplying blood to the brain are blocked, which can potentially lead to memory loss and other negative cognitive symptoms. According to one early study, pramiracetam reportedly improved memory decline in chronic cerebrovascular insufficiency patients .
any drug, pramiracetam has the potential to cause adverse side-effects.
Importantly, because this compound is relatively new, there is not much evidence about how safe it is for human users, or how frequently it might lead to negative side-effects.
For this reason, we would strongly advise against experimenting with this compound until more data about its safety is available.
According to one preliminary study in both animal and humans, pramiracetam was reported to be relatively safe and “well-tolerated,” causing few major side-effects .
Similarly, a randomized control trial in 12 healthy volunteers reported no adverse side-effects at any dosage (from 400 to 1,600mg) . However, this study only tested a single, one-time dose of pramiracetam, so no firm conclusions can be made about the potential risks of long-term use of pramiracetam from this study.
Dosage of Pramiracetam
Note: The information in this section contains information about the dosages commonly used by some of the early studies that have been done on pramiracetam so far. The information below is not intended as a guide for the personal use of oxiracetam, as adequate data about its potency, safety, or overall effects in healthy human populations is not currently available.
Pramiracetam typically comes in the form of powder, pre-made capsules, or tablets. Some users report that the powder form has a strong unpleasant taste, and therefore prefer to use the capsule or tablet forms instead.
According to some researchers, the powder and capsule forms may have a faster absorption rate than the tablet form. However, the overall potency and effectiveness are believed to be roughly equivalent across the different forms .
In one of the few trials that have been done so far, a total dose of 1,200 mg was used, divided either into two 600-mg doses or three 400-mg doses spread throughout the day .
As a member of the racetam family of drugs, pramiracetam is believed to depend on choline for its effects, and using it may, therefore, deplete the body’s choline supply.
For this reason, it is sometimes recommended to combine racetams with a source of choline, such as alpha-GPC or citicoline .
However, this suggestion is based solely on data from one animal study, so this shouldn’t be interpreted as any kind of “official” or “medically-approved” recommendation.
Limitations and Caveats
Pramiracetam is currently not approved by the FDA for the treatment of any disease.
Available data on this drug’s effects is highly limited, and no strong conclusions about its cognitive effects or its overall safety can be made until a lot more research is done – especially large-scale clinical trials in young, healthy adults.
Therefore, many other so-called “nootropic” drugs, many of the claims made about it online are often hype, or rely on anecdotal reports from people who have personally decided to experiment with it. These claims should be treated with skepticism until more hard scientific data is available – and in the meantime, the use of pramiracetam cannot be officially recommended or endorsed.
Pramiracetam: Nootropic Benefits, Effects, Dosage, and More
Pramiracetam may improve memory and provide a boost while studying
The most notable effect pramiracetam has is on memory and learning. Many nootropics users swear by its ability to improve study sessions or efficiently crank out work.
Most of the available clinical studies focus on older or cognitively impaired populations.
However, we can still use them to see the advantages of pramiracetam for young and healthy brains.
One study found that supplementing pramiracetam for 18 months could greatly improve memory and recall among men who suffered from brain injury.
The supplement group performed much better on memory tests than the placebo group, even a month after pramiracetam was discontinued.
This points to the permanent long-term benefits of using this nootropic.1McLean A Jr, Cardenas DD, Burgess D, Gamzu E. Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia, Brain Inj. 1991
Another trial looked at a small group of healthy elderly patients. They were either given hands-on memory training, pramiracetam, both, or neither.
Then, they were given a series of memory tests.
The group that had both the pramiracetam and the memory training scored the best, followed by pramiracetam only, memory training only, and finally the control group.
Researchers concluded that pramiracetam had a very noticeable positive effect on the participants.2De Vreese LP, et al. Memory training and drug therapy act differently on memory and metamemory functioning: evidence from a pilot study, Arch Gerontol Geriatr. 1996
Due to its effects on memory and learning, some people use pramiracetam for ADHD. There have not been any direct studies on this use, but some users find it effective.
Pramiracetam is also known to improve overall cognitive ability by modulating ACh production. This overlaps with its neuroprotective qualities as well.
Multiple studies have looked at pramiracetam’s effects on repairing cognitive ability in patients suffering from brain injury or neurodegeneration.
Experiencing a stroke, physical damage or a disease such as Parkinson’s can rapidly deteriorate thought process.
Luckily, pramiracetam can repair overall mental function in these cases. Patients who take pramiracetam see an across-the-board improvement after a few weeks compared with patients who don’t.3Dziak LA, Golik VA, Miziakina EV.
Experience in the application of pramistar, a new nootropic preparation, in the treatment of memory disorders in patients with cerebrovascular pathology, Lik Sprava. 2003 4Malykh AG, Sadaie MR..
Piracetam and piracetam- drugs: from basic science to novel clinical applications to CNS disorders, Drugs. 2010
To date, there haven’t been any trials involving non-impaired participants. However, pramiracetam’s effects on cognition should translate to average, healthy adults who are looking for a mental boost. Judging from anecdotal reports, this should be the case.
Pramiracetam can prevent cognitive degeneration and preserve brain health
Pramiracetam was originally conceived as a drug to treat Parkinson’s, due to its ability to protect the brain and preserve cognitive function as you age.
Aging is associated with a decline in ACh, cerebral blood flow, and choline uptake, all of which this nootropic can reverse.
There is clinical evidence that it can help even otherwise healthy people maintain brain health.
One study induced temporary amnesia in healthy participants by injecting a compound called scopolamine.
The group that took pramiracetam did about 50% better on cognitive tests than those receiving placebo.
This is clear evidence of how it can preserve mental abilities through adverse conditions. Pramiracetam should also prevent natural age-related memory loss.5Dziak LA, Golik VA, Miziakina EV. Experience in the application of pramistar, a new nootropic preparation, in the treatment of memory disorders in patients with cerebrovascular pathology, Lik Sprava. 2003
Another study shows that pramiracetam was effective in restoring memory loss/disorientation in patients with mild cerebral trauma.
It also alleviated headaches, dizziness, and nausea.6Tkachev AV. Application of nootropic agents in complex treatment of patients with concussion of the brain, Lik Sprava. 2007
Pramiracetam vs Piracetam
Pramiracetam is much more potent and is used in lower doses than piracetam. It is also significantly more bioavailable.
We consider pramiracetam significantly more effective than its predecessor on pretty much every level.
Pramiracetam Benefits, Dosage, Stacking and Side Effects
Pramiracetam is a Racetam formula. This nootropic supplement is one of the first supplements of this kind, which is why it has a similar name as Piracetam, the first one. Although Pramiracetam has the same effects as Piracetam it is thirty times more powerful in boosting brain power.
Pramiracetam is the strongest nootropic that you can find on the market when it comes to brain-boosting capabilities. It has become very popular because it helps users improve their memory, concentration and focus in great measure. Pramiracetam can be used on its own and together in a stack with other supplements.
This is a very potent compound, and depending on the producer it can be 10 to 30 times stronger than its closest relative Piracetam. Most other Racetams are quite similar and you need to dig a bit deeper to find their differences, but Pramiracetam is truly unique and it excels with its strong effects.
Pramiracetam also works as a neuroprotective agent that slows down cognitive decline and improves memory. The effects of this nootropic alone and with powerful stacks have made it popular with many people including students, scientists, ambitious employees, and so on.
Pramiracetam was first synthesized in 1970 and it arrived in the US 7 years later. This nootropic has achieved great success in Europe, but it’s quickly breaking into the US market as well.
Although it’s still not FDA approved, chances are that the government will recognize its value and change things, especially when you consider that many European countries use it as a prescription drug for various neurological conditions such as ADHD, dyslexia, and dementia.
Pramiracetam Benefits and Effects
The most important benefit of using Pramiracetam is memory retrieval and formation. No other Racetam is nearly as effective when it comes to improving memory. This nootropic simply stimulates all parts of the brain that are in charge of memory functions.
This is why it’s no surprise that everyone who has used it says that they’ve experienced great improvements in memory and were able to learn things more easily while retaining the memory of events, places, knowledge, and people for a long time.
However, the biggest benefit of such memory improvements is that people are able to study faster, more thoroughly, and more easily. In my personal experience, I found studying on Pramiracetam a lot more fun. If you are a nerd me, you will definitely enjoy this supplement as much as I have.
Pramiracetam also increases the amount of blood that is pumped to the brain and the amount of oxygen that the brain has, and stabilizes glucose metabolism.
In other words, overall brain function and mental health are significantly improved.
This leads to benefits such as more mental energy, improved alertness, ability to think more clearly, and improved audio and visual perception.
Although it’s rarely mentioned, this nootropic also has great neuroprotective capabilities.
Many studies have shown that Pramiracetam can help people in preserving memories, which is just as important as making memories.
Making memories will do you no good if you forget what you’ve learned very quickly. This is why in Europe many doctors prescribe this nootropic to older people with memory issues.
Similarly to these things, Pramiracetam offers benefits for treating memory loss in general, help with neurological disorders and help treat cognitive problems that were caused by some kind of brain injury.
This is why many new studies are currently performed in the US right as we speak and, as I mentioned earlier, many European countries use it to treat or help with ADHD, dyslexia, Alzheimer’s disease and dementia.
Pramiracetam is the strongest nootropic that you can find on the market when it comes to brain-boosting capabilities
How Pramiracetam Works
Pramiracetam works similarly to all of the Racetams and nootropics. The main function of this supplement is to cause a neurotransmitter release. The release of these brain chemicals improves signal transmission amongst nerve cells within the brain. However, un most Racetams, Pramiracetam does this in a slightly different way.
It has a more all-around effect, as all the neurotransmitter receptors are stimulated, un with other Racetams that work on certain specific locations.
This creates a more balanced effect and overall more powerful brain stimulation. The main site for this process in the brain is called the hippocampus.
This is because the hippocampus has the biggest role when it comes to forming and storing both long-term and short-term memories.
Pramiracetam increases levels of Choline located within the hippocampus.
Choline is a precursor of Acetylcholine, a neurotransmitter that plays one of the most important roles in various cognitive functions such as learning, memory and concentration.
This means that Pramiracetam indirectly stimulates all Acetylcholine receptor sites leading to better activity within the hippocampus.
This additional activity also improves the ability to form new memories while being able to recall old ones. An added benefit of this hippocampus activity increase is better blood circulation through the brain. This means that the overall cognitive abilities and general alertness of the mind will be improved as well.
Overall, this means that your brain will get more oxygen and energy. Now, you might think that you can just consume some caffeine if you want to increase the energy levels of your brain. However, caffeine doesn’t improve the blood circulation to the brain and throughout it, making it somewhat difficult to focus.
with all Racetams and nootropics, the correct dosage depends on the individual using the supplement and the effect they are trying to achieve. However, a standard amount per day is considered to be anywhere from 500mg to 1300mg and it must be split into 2-3 doses.
I read online that 1200mg is the right dosage and I tried that amount. It seems to hit that sweet spot and give all the benefits you’d expect. It worked well for me, but there are people who said they needed much less, while on the other hand some needed larger doses.
It is essential to split your daily intake though, as Pramiracetam lingers within the system for about 5 hours.
The better you are at taking even doses throughout the day, the more consistent the effect of the supplement will be, as you will always have the same levels of it in your system.
Pramiracetam doesn’t have any unexpected effects and even if someone surpasses the recommended dosages chances are that nothing will happen.
This is why a lot of users to experiment with this nootropic, test dosages and the number of doses during the day to find that sweet spot of benefits. However, it’s best to start with smaller doses and learn how the supplement works before you try anything radically different. Capsules are usually 200mg, so you will have to take them more often during the day.
It’s recommended that you take it after a meal, or a snack. Remember that this nootropic burns choline very effectively and the loss of choline can cause negative effects within the brain, so make sure that you add food with choline to your diet once you start using this Pramiracetam. If not, there are stacks that make up for this choline loss.
Stacking is combining multiple supplements in order get different effects. The main idea is to get the right elements for creating a synergic effect and not just get additive benefits. By getting elements that amplify each other, you will get a more noticeable benefit and a wider range of effects.
Pramiracetam is used in many nootropic stacks, simply because it has the power to enhance their effects and make them more potent. However, let’s see which other supplements can be combined with Pramiracetam as well.
The first supplements that are commonly stacked with Pramiracetam are the ones that have a lot of or cause increased choline production.
The best supplements for this are Alpha GPC and Citicoline. This is how you will be able to make up for the choline loss instantly without having to make any dietary changes.
Additionally, choline protects users from headaches and this is one of the most common side effects of all nootropics.
Additionally, if you want to get a broader spectrum of effects you can try combining Pramiracetam with Aniracetam. This nootropic also reduces anxiety and stress, and helps users feel comfortable. Aniracetam greatly improves your mood, and helps you increase productivity and develop a positive mental drive.
The combination of these two could give you all the tools you need to learn, socialize, discover things, or be alert in a competition or during a public performance. Given the fact that Pramiracetam has no effects on your mood whatsoever, this is a good stack.
Armodafinil, Modafinil, or Adrafinil
All of these three are also smart drugs that have the power to make users awake and more alert, giving them more mental energy and keeping them focused. People use it must for long periods where they have to be focused and put a lot of strain on their brain such as preparing exams or writing books.
By stacking Pramiracetam with these smart drugs your elevated amount of concentration can be better focused into some meaningful activity, instead of letting all of your hectic thoughts slip into thin air. These smart drugs can be bought with a prescription almost anywhere.
Pramiracetam Side Effects
I mentioned before, Pramiracetam is tolerated really well by most people, even if they go over the recommended dosages. There isn’t a lot of data on any serious side effects or people testifying that they’ve had big issues because they used Pramiracetam. It’s actually considered a low-risk drug.
As with most nootropics, however, the most common side effect that you can have with Pramiracetam are headaches. In most cases, these headaches are caused by choline depletion within our brain and this is why I mentioned before that you can either use other supplements or change your diet to make up for all the choline that is being spent.
I’ve also found instances where people said that they were feeling agitated or nervous after using Pramiracetam. In most cases, the users simply took very high dosages and their bodies probably weren’t able to handle such a high dose of the supplement. This is why I mentioned earlier that you should start with a mild dose and slowly increase it as your body gets used to the drug.
This is about the only side effect that you can expect from this supplement. It’s really safe to use in the long term and there is even a study showing that long-term use can actually be very beneficial for supporting cognitive functions and repairing brain damage caused by old age.
My Experience with Pramiracetam
I tried Pramiracetam in both powder and capsules and I will tell you why. I first ordered the powder online because I used other supplements before and I got used to mixing powders with milk, water, juice or something that. I had a terrible time though, because the Pramiracetam powder doesn’t dissolve in water.
On top of that, when I tried the powder it had a terrible taste. It was fish mixed with dirt and filled with iron. I really disd it and it was hard for me to even use all of the powder I had. Let me say that I don’t fish and maybe others won’t find it as repelling as I did.
This is why I went with capsules and they were a lot better. I started with three 200mg capsules per day, with 8 hours between each one. This was also very convenient, because you can always be sure that the doses are equal and not have to waste time measuring powder to make sure that you have the exact dose that you need.
The dose that I got to was 1200mg per day and I took 2 capsules at a time.
Given the fact that I’m a writer I had trouble concentrating, getting over creative blocks and remembering important details that could help me write better.
Naturally, this supplement has helped me a lot and I haven’t felt any side effects. I made sure to eat food rich with choline everyone suggested and it really worked.
Many studies have shown that Pramiracetam can help people in preserving memories, which is just as important as making memories.
In rare cases I had trouble focusing my thoughts on one thing and I wanted to tackle many things at once. I think that this is simply because I took a larger dose and didn’t stack it with Aniracetam. Still, this only happened once or twice and it lasted for a short time.
Where to Buy Pramiracetam
You can find Pramiracetam in two forms: powder and capsule. In my experience capsules are better and they save you the trouble of having to taste something so bad to get all the good effects.
It’s possible to find Pramiracetam in retail stores, but only a few have it. This is why it’s best to order it online. Not only can you get it quickly, but you can read more about it, ask questions and find out whether the vendor has a laboratory in which they test the purity of the product.
Currently, Pramiracetam is not regulated by any country, but you need to make sure that you are getting a quality product from people that know what they are doing. I got mine here form AbsorbYourHealth and I’ve had a great experience with this product.
Buy From AbsorbeYourHealth
Pramiracetam is one of the most effective Racetams and its greatest benefits include better cognition and memory improvement. It can be used for Alzheimer’s and other similar diseases and help users develop a better attention span. Remember to start with smaller doses, never take it on an empty stomach and make sure to get extra choline in some way.
Compared to other nootropics, this is one of the most potent supplements and everyone who’s tried it has felt its effects immediately. It works quite well, as long as it is taken in several smaller doses, and has a positive long-term effect, making it one of the best Racetams and nootropics overall.
Pramiracetam is a synthetic derivative of piracetam, the first laboratory-created nootropic, but is significantly more potent.
Discovered and developed by Parke-Davis in the 1970s, pramiracetam has been extensively studied as a potential treatment for cognitive problems and memory loss associated with Alzheimer’s disease and brain injury and as a treatment for a variety of central nervous system disorders.
Pramiracetam has been clinically proven to improve memory in healthy elderly adults with memory loss and enhance overall cognition in young adults with memory problems.
Anecdotal evidence suggests that pramiracetam optimizes overall brain function and increases focus and productivity making it a popular choice among students and others who want to enhance their mental abilities.
Pramiracetam has not been approved for any specific use by the USFDA and is unregulated in the US, where it can be legally purchased, possessed, and used.
Pramiracetam may not be legally sold in Canada but can be legally imported into Canada for personal use.
It is available by prescription Europe, where it is sold under the brand names Neupramir, Pramistar, and Remen for treatment of dyslexia, ADHD, dementia and memory problems caused by Alzheimer’s disease and other neurological conditions.
Benefits and Effects of Pramiracetam
Pramiracetam is a true nootropic, created specifically to enhance cognition. Its benefits and effects include the following:
Pramiracetam is a proven memory enhancer, extensively tested over several decades and shown effective in both animal studies and clinical trials of young adults with cognitive impairment due to brain injuries.
Pramiracetam improves memory both by stimulating the hippocampus, the part of the brain primarily responsible for the creation of new memories and by acting as a potent anti amnesic that reduces forgetfulness. This dual action makes pramiracetam a very effective memory booster, and many users also report significant improvement in speed of recall, a claim that has been corroborated by animal studies.
Increased Alertness and Expanded Learning Capacity
Pramiracetam’s reputation as a general cognitive enhancer that increases alertness and expands learning capacity has made it a popular choice among students seeking a reliable study aid.
Though no human studies on these specific effects have been documented, animal studies indicate that pramiracetam contributes to the mechanisms underlying learning and memory improvement by increasing neuronal type nitric oxide synthase (NOS) activity in the hippocampus. NOS activity is associated with neural development and brain plasticity, both of which are crucial to all aspects of cognition.
Pramiracetam is also known to increase high-affinity choline uptake in the hippocampus, thus indirectly fueling the production of acetylcholine, an important neurotransmitter that is strongly associated with learning and cognition.
Open-label trials in patients with primary degenerative dementia show that Pramiracetam effectively reversed amnesia, significantly enhancing recall and reducing forgetfulness.
In other studies, which measured the effects of pramiracetam and other racetam-class nootropics on patients with mild to moderate dementia, there were measurable improvements to cognition and memory. These results are ly explained, at least in part, to the nootropic’s enhancement of existing neurotransmitters.
Though pramiracetam has not been approved as an Alzheimer’s treatment in the US, it typically prescribed in Europe for treatment of dementia and other cognitive issues related to Alzheimer’s disease and other neurological disorders.
While there is no documented research on pramiracetam’s effect on social fluency, many users report that it makes them more conversationally creative and socially fluent.
This effect may be explained, at least in part, by pramiracetam’s reputed emotional blunting effect, which is sometimes described as similar to that of Ritalin.
This effect may reduce social anxiety and, in turn, enhance social fluency.
Pramiracetam is known to have considerable neuroprotectant effects, capable of improving cognition in humans who have experienced brain trauma.
Studies have also shown it to have a demonstrable neuroprotective effect when used during coronary bypass surgery, as well as in the treatment of cognitive disorders of cerebrovascular origin.
How It Works
most nootropics, pramiracetam affects the release of neurotransmitters, brain chemicals that transmit signals from one nerve cell to another. But pramiracetam does it indirectly, in a manner somewhat different from the usual actions of racetam supplements, and it stimulates the brain in other ways as well.
Most racetams work by directly stimulating specific neurotransmitter receptor sites and thus increasing the production and release of specific neurotransmitters.
However, pramiracetam doesn’t directly affect neurochemical levels, and it doesn’t appear to have an affinity for any major neurotransmitter.
Its primary mechanism of action is a significant increase in high-affinity choline uptake in the hippocampus.
Choline is a precursor of acetylcholine, a neurotransmitter profoundly involved in all cognitive processes, including learning speed, memory, and concentration.
By stimulating choline uptake, pramiracetam indirectly modulates the release of acetylcholine and stimulates increased activity in the hippocampus.
Because this part of the brain is essential to memory function, the general stimulation that pramiracetam creates can improve both the formation of new memories and the retention of reference or long-term memories.
The increased activity in the hippocampus also increases cerebral blood flow, which enhances alertness and improves cognitive abilities in general.
Pramiracetam may have other mechanisms of action as well. Researchers have hypothesized that in addition to its effect on the brain, pramiracetam acts in peripheral sites outside the brain that rely on the adrenal glands.
Animal studies suggest that pramiracetam may also increase or restore brain membrane fluidity, which facilitates cell signaling.
Un many other racetam class nootropics, pramiracetam doesn’t appear to actively alter either wakefulness or emotional states. This can be explained by pramiracetam’s limited influence on the production and release of the neurotransmitters that have the greatest effect on mood and anxiety levels such as serotonin, GABA, and dopamine.
Pramiracetam is fat-soluble rather than water-soluble, which means it is absorbed into the bloodstream via fatty acids. It reaches peak concentrations and maximum bioavailability relatively quickly, generally within 30 minutes, and it has a moderately long half-life of 4.5-6.5 hours.
The existing human studies used a total daily intake of 1200 mg of pramiracetam, divided into two or three doses per day.
They did not indicate that this dosage was optimal, but it was found to be both effective and well-tolerated and may be a good reference point in determining personal dosage needs.
It is always wise to start with the lowest possible effective dose and adjust amounts as needed.
The fact that pramiracetam is fat rather than water-soluble means that mixing the powder with water or any nonfat liquid is difficult; instead of dissolving, it will simply float on the surface. Some users report dissolving their dose of pramiracetam powder with a small amount of oil, which may also enhance absorption and bioavailability.
Many individuals opt to take pramiracetam in capsule form due to its pungent flavor.
Pramiracetam works well on its own but may also be a powerful potentiator for other nootropics, increasing their effectiveness.
It is a particularly effective potentiator for other racetams, making it a natural addition to most nootropic stacks.
Adding a choline supplement to a pramiracetam stack could have multiple benefits. Not only can it enhance pramiracetam’s effects, but it can also prevent headaches, which are the most commonly reported side effect.
Because pramiracetam has such potent effects, it is advisable to use it on its own for a trial period before combining it with other nootropics.
Pramiracetam and Oxiracetam Stack
Stacking pramiracetam with an energy enhancer adrafinil or oxiracetam can intensify the mental alertness and extend it over a longer period.
Pramiracetam and Aniracetam Stack
Stacking pramiracetam with a powerful anti-anxiety agent aniracetam can give users heightened focus and concentration while improving mood and reducing feelings of mental strain and anxiety. Some users say this stack promotes social fluency and improves their public performance ability.
Pramiracetam is usually well tolerated even at high dosages, and very few adverse side effects have been documented.
There are infrequent reports of minor and transitory side effects, including headache, gastrointestinal distress, and feelings of nervousness or agitation.
In many cases, side effects are associated with high dosage and can be avoided by reducing amounts ingested.
Headache associated with choline depletion is a typical side effect of racetam type nootropics and may possibly be prevented by taking pramiracetam in conjunction with supplemental choline.
Pramiracetam is non-addictive, and no significant adverse effects of long-term use have been documented. There is evidence that pramiracetam may even promote brain health and even restore function in aging brains.
Where to Buy
It isn’t usually possible to find pramiracetam in retail stores, but it is available from specialty online stores that carry nootropics. It is important to order from reputable vendors.
We recommend PureNootropics.net for ordering pramiracetam and other nootropics. All their products are tested for purity by 3rd party laboratories.
Pramiracetam is a unique and powerful nootropic that has been proven to enhance memory, improve overall cognition, and act as a neuroprotectant.
Though Pramiracetam is prescribed as a dementia treatment in Europe, in the US and Canada it is most frequently used off-label as a study aid and general cognition booster.
The pros of pramiracetam include the fact that it’s safe and generally well tolerated, with few reported side effects; it’s powerful, fast-acting, and relatively long-lasting, effective on its own and with other compounds in nootropic stacks. Users generally report that it helps them study efficiently and remember clearly, along with increasing alertness. Many users also say it enhances their sense of social fluency.
The cons of pramiracetam include the taste, which is particularly pungent, and the price, which tends to be higher than that of other racetam type nootropics.
Though some users report that pramiracetam tends to blunt their emotions, reactions to that effect are mixed; some people regard it as welcome objectivity and relief from social anxiety, while others say it makes them feel dissociated.
Overall, pramiracetam is widely accepted as a safe, effective nootropic. If you’re interested in improving your memory, learning speed, and general mental acuity, it may be worth considering.
Pramiracetam was last modified: November 7th, 2019 by Braintropic.com Research Team
Planning to start a new supplementation regimen? See our medical disclaimer.
This page was last updated on November 7, 2019.