Etizolam, Reviews, Sleep Effects, Uses & Warnings

Etizolam Abuse and Side Effects

Etizolam, Reviews, Sleep Effects, Uses & Warnings

Etizolam is a prescription drug that’s very similar tobenzodiazepines, but it has a slightly different chemical structure. In the world of chemistry, etizolam is in a category called thienotriazolodiazepine, which is a group of benzo analogs.

The drug causes similar effects to benzos, such as anti-anxiety, anticonvulsant, and hypnosis. It’s used for the same medical purposes, such as treating insomnia, anxiety, and panic disorders. However, in common doses, etizolam is much more ly to cause anxiety relief than sedation.

It also shares the same mechanism of action in the brain as benzodiazepines. The drug is GABAergic, which means that it interacts with a brain chemical called gamma-aminobutyric acid (GABA), which is responsible for activating its receptor in the brain to promote relaxation and sleep.

Etizolam binds to GABA receptors and increases the efficacy of the GABA chemical, giving it a boost in its anti-anxiety and hypnotic qualities. It also inhibits the reuptake of certain feel-good chemicals such as serotonin, norepinephrine, and dopamine, which may contribute to its ability to relieve anxiety.

Unfortunately, etizolam also has some of the adverse effects that benzos have, including respiratory depression, dizziness, drowsiness, memory loss, and erectile dysfunction. When compared to some benzodiazepines and their analogs, etizolam is more ly to cause euphoric effects. Euphoria can lead to psychological addiction by affecting the reward center in your brain.


Etizolam is a depressant drug that can be used recreationally or as a method of self-medication. Though the drug is illegal in a few states in the U.S., it is not “federally scheduled,” which means it’s not controlled by the federal government.

According to the U.S.Drug Enforcement Administration, the drug can be bought online or in stores, where it’s sold as a “research chemical.

” It can also be sold from illicit sources, which increases the risk that the drug can be mixed with other dangerous or unknown chemicals.

People who buy etizolam illegally may be doing so to use it recreationally, to satisfy an existing benzodiazepine dependence, or to self-medicate for problems anxiety or insomnia.

The drug can cause euphoria when taken in high enough doses, and even shows a higher probability of causing euphoric effects over other benzodiazepines.

Self-medication is a form of abuse that involves taking prescription strength medication without consulting a doctor. Without medical advice, it can be hard to know the right dose for your needs. Taking the drug in high doses or for longer than recommended can lead to physical dependence or addiction.

The drug may also be mixed withalcohol, opioids, or other depressants for more intense highs, but this behavior also dramatically increases the risk of a fatal overdose.

According to the National Institute on Drug Abuse,30 percent of fatal opioid overdose also involved benzodiazepines.

Benzos and their analogs rarely cause fatal, accidental overdoses on their own, but they become much deadlier when they’re combined with other substances.


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As a sedative-hypnotic drug, etizolam will cause side effects that are similar to other depressants. A large enough dose will lead to intoxication that’s similar to getting drunk. You may feel a euphoric sense of calm, relaxation, or a lack of inhibitions.

But alcohol, this intoxication will also come with a loss of motor control, slurred speech, drowsiness, excessive sedation, a struggle to maintain consciousness, a greater lihood of taking risks, dizziness, headaches, and confusion.

In less frequent cases, etizolam can also cause tremors, nausea, and incontinence.

Prolonged use of the drug can lead to chemical dependence and addiction, and the withdrawal symptoms can be serious. If you abruptly stop taking the drug, it can cause seizures and a potentially fatal condition called delirium tremens.


As a psychoactive drug and a central nervous system (CNS) depressant, etizolam can have significant effects on your brain chemistry. most psychoactive drugs, etizolam works by changing the chemical communications in your nervous system.

Because it’s GABAergic, it specifically affects GABA receptors to influence your brain chemistry in a way that’s consistent with CNS depressants. However, as with other depressants, etizolam can cause chemical dependence, addiction, and withdrawal symptoms.

As your brain gets used to the etizolam in your system, it may start adapting around its presence and using it for normal brain functions.

Your brain may start adjusting its natural chemistry around etizolam, which decreases inhibitory chemicals that would make you relax and increases excitatory chemicals to counteract the drug.

Therefore, you may start feeling you’re becoming more tolerant, so you may feel you have to take more of the drug to achieve its normal effects.

Chemical dependence is characterized by your brain becoming reliant on the drug to maintain normal functioning. To you, it will feel you need to use the drug to feel normal. You may no longer use it as recreation, but rather to avoid feeling uncomfortable symptoms.

If you stop using the drug in social settings and start using it alone, you may become dependent on it. One particularly telling red flag is using the drug in the morning, outside of prescribed use. If you feel compelled to use it as soon as you wake up, it could be because your last dose wore off the night before.

Since etizolam can affect the levels of those feel-good chemicals in your brain, it can cause your reward center to mistake the drug for a naturally rewarding activity such as eating a good meal. Your reward center is designed to pick up on activities that are good for you, such as eating and sleeping.

During those activities, chemicals such as endorphins, serotonin, norepinephrine, and dopamine are released. Your reward center takes notice and teaches your brain to seek those activities again.

Drugs etizolam elevate the level of those feel-good chemicals in your system, so they can affect your reward center in this way.

The result is powerful cravings that compel you to use the drug the way other people drink water.

Addiction is identified by compulsive drug use, despite serious consequences. Has the drug started taking over your life, and disrupting your health, relationships, jobs, and hobbies? Are you still unable to quit? If so, you may be addicted.

Addiction is a disease that affects the brain, so it often gets control. In many cases, people with substance use disorders are in denial that their drug use has become a problem, but you may also feel powerless to do anything to stop it.

Starting the Recovery Process

Is your loved one struggling with etizolam abuse or addiction? Are you? If so, it’s important for you to treat it with the seriousness it requires and get help before it’s too late.


Buy Etizolam Online | Dosage, Side Effects, Dangers, Science

Etizolam, Reviews, Sleep Effects, Uses & Warnings

Etizolam is a thienodiazepine compound which is related to the benzodiazepine drug class. [2]

Etizolam is not authorized by the FDA for medical use in the United States. However, it is an unscheduled drug and is legal to use for research purposes. [3]

Etizolam Benefits and Effects

Etizolam was originally developed as a treatment for anxiety and sleep disorders but has been found to be effective in other treatments too. [2]

Reduces Anxiety

Etizolam were found to show a marked improvement in chronic anxiety and phobic ideas. [5] Another study, patients  – treated over 5 weeks – showed significant improvement in anxiety and depressive symptoms. [6]

Etizolam was compared with Alprazolam and Bromazepam in the treatment of generalized anxiety disorder. Etizolam outperformed both of the other drugs in the trial for its antidepressant effect. [7]

May reduce auditory hallucinations in schizophrenia patients

One study using Etizolam showed a complete disappearance of auditory hallucinations in a schizophrenic patient. [8]

May combat insomnia

A study using rats showed that a regular dosage of Etizolam significantly reduced the sleep latency of the subjects. Insomnia returned as Etizolam dosage stopped. [9]

May reduce pain

Etizolam was used to test pain reduction from tension-type headaches, using a combination of Etizolam and NSAID. Young and female patients showed a statistically significant reduction in pain using the combination of Etizolam and NSAID. [10]

How Etizolam works

Etizolam is absorbed via the gastro-intestinal tract. Peak plasma concentrations occur between 0.5 – 2 hours in human trials, with half-life at about 3.4 hours [12], with bioavailability between 90 to 95% [14] Excretion is via urine (30% in rats and 40% in mice) and faeces (70% in rats and 60% in mice) [13]

Etizolam interacts on the benzodiazepine site of the GABA-A receptor; binding to its regulatory site and causing the opening of GABA induced Chloride channels, facilitating GABA transmission through the channel. [13]

Studies show that treatment using Etizolam may reduce the need for surgery in the case of chronic subdural hematoma. [1]


Etizolam dosing tend to be in the range 0.25g to 3.0 g tablets; taken one, to three times daily.

One overdosed patient was admitted to an emergency room after consuming a large quantity of Etizolam tablets along with other unknown substances. [15].

Etizolam is not recommend for use by pregnant or breast-feeding women;  it can pass through the placenta. In addition, benzodiazepines Etizolam are excreted in breast milk. They can have a sedatory effect on the neonate. [16]

Side Effects

Pyrexia or raised temperatures is the most common side effect. [17]

Patients taking Etizolam were found to have a significant prolongation of P300 latency. [18] Day-time drowsiness is also documented. [6]

One case of Etizolam dependency has been reported. [19] However, the patient dropped a follow up program. In another case, a female patient was successfully weaned from Etizolam through a planned reduction in dosage and replacement drug. [20]


Etizolam: 8 Things You Should Know About This Addictive Drug

Etizolam, Reviews, Sleep Effects, Uses & Warnings

There are a variety of medications used to treat anxiety, panic disorders, and sleep disorders in America and around the world, but some may also be abused recreationally for the purpose of getting high. One such drug is etizolam. Here are eight important things you should know about this addictive drug and what you should do if you or a loved one becomes addicted.

  1. Etizolam is chemically related to benzodiazepines.

According to the DEA, etizolam is chemically similar to a class of drugs called benzodiazepines, which are central nervous system (CNS) depressants. These types of drugs are commonly used to treat anxiety and sleep disorders.1

  1. Etizolam is not currently legal in the United States.

Etizolam is used medicinally in Japan, Italy, and India, but it is still illegal in the U.S. It was first introduced in Japan in 1983 and is available in 0.25 mg, 0.5 mg, and 1.0 mg tablets in countries where it is legal for medical use.1,2

  1. Etizolam is often sold as a “research chemical” in the U.S.

Despite the fact that it is an illegal drug, etizolam is often sold as a research chemical online and in retail stores. It has been sold as powder, tablets, or spiked onto blotter paper.

According to the Psychoactive Substances Act, which came into effect on May 26, 2016, it is illegal to supply or import this drug for human consumption.

2 However, marketing etizolam as a research chemical allows companies to bypass the law (at least temporarily).

  1. Etizolam is an extremely powerful and addictive drug.

Etizolam is highly addictive. According to the DEA, etizolam is 10 times more potent than Valium for producing hypnotic effects.1 Its potency gives it a very high potential for abuse, making it appealing for recreational abuse in America. The length of time it takes for etizolam addiction to develop will vary the individual and his or her circumstances.

  1. A diverse population of people abuse etizolam.

Etizolam is misused recreationally by teens, young adults, and older adults a. When taken in low doses, benzodiazepines etizolam can be very helpful in managing sleep and anxiety disorders, but they are frequently abused and taken in larger, more frequent doses to produce a euphoric high.

  1. Etizolam abuse comes with many dangerous side effects and risks.

Abusing any benzodiazepine is very dangerous, especially when alcohol is abused simultaneously. Common side effects and risks of benzodiazepine abuse include3:

  • Drowsiness
  • Dizziness
  • Difficulty breathing
  • Memory impairment
  • Decreased coordination
  • Slurred speech
  • Blurred vision
  • Overall physical weakness
  • Coma

Abusing etizolam may also cause organ failure. The best way to discontinue etizolam abuse and recover from etizolam addiction is by enrolling in a medically assisted drug detox program and long-term drug rehab.

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  1. Abruptly stopping Etizolam abuse is dangerous.

If you are addicted to etizolam and you abruptly stop taking it, you may begin to experience very uncomfortable withdrawal effects, such as4:

  • Seizures
  • Anxiety
  • Restlessness
  • Muscle pain/stiffness
  • Nausea and vomiting
  • Headache
  • Insomnia
  1. If you are addicted to Etizolam, it’s very important that you get help as soon as possible.

Etizolam addiction and abuse is a serious disorder and should be addressed immediately. Any type of benzodiazepine abuse is extremely dangerous and can result in uncomfortable physical and mental side effects, overdose, or even death.

Talk to a Treatment Expert – (888) 857-0557FREE INSURANCE VERIFICATION & CONSULTATION

Etizolam Withdrawal and Detox

If you abuse etizolam regularly and develop a physical dependence, you may experience uncomfortable physical and psychological symptoms when the abuse suddenly stops. This is called withdrawal.

Etizolam is a benzodiazepine, therefore, etizolam withdrawal produces similar side effects to that of other benzos Valium and Ativan. Etizolam withdrawal will be different for everyone, but some common side effects are:

  • Anxiety
  • Restlessness
  • Insomnia
  • Muscle tension
  • Sweating
  • Blurred vision
  • Muscle spasms

If you are addicted to etizolam and decide to stop taking the drug, it’s extremely important that you don’t do so on your own at home. Etizolam withdrawal (and benzodiazepine withdrawal in general) can be very dangerous and may result in unexpected or life-threatening medical emergencies such as seizures.

The safest and most comfortable way to detox from etizolam is with a medical detox program.

A drug detox facility Briarwood will provide medical and clinical supervision throughout your detox program to ensure that you are comfortable and your etizolam withdrawal is progressing safely.

Additionally, if any unexpected medical complications do arise during the process, you’ll have a whole team of medical detox experts to treat you.

How to Get Help for a Loved One Who Is Addicted to Etizolam

If you or a loved one is misusing benzodiazepines such as etizolam, Briarwood Detox Center can help you achieve a stable life in recovery.

Our individualized benzodiazepine detox programs are designed to meet your unique needs and provide the most comfortable drug detox experience possible.

Our multidisciplinary treatment team will work together to provide personalized and appropriate physical and psychological treatment that will give you the best chance for long-term success in sobriety.

Benzodiazepine abuse is not always intentional at first, but it can quickly evolve into a lifestyle of drug addiction. If you are addicted to your anxiety medication, you are not alone in this struggle. Call Briarwood Detox Center today to learn more about medically assisted drug detox programs at our detox locations in Austin and Houston, TX.



Etizolam Use and Anxiety Disorder

Etizolam, Reviews, Sleep Effects, Uses & Warnings

HomeEtizolam Use and Anxiety Disorder

Etizolam is a benzodiazepine analogue similar to diazepam or Valium. It works other benzodiazepines, although it has a slightly different chemical makeup. Where benzos have a benzene ring, etizolam has a thiophene ring.

Etizolam depresses the central nervous system and animal testing seems to point toward its effectiveness as a muscle relaxer, anti-convulsion medication, sleep aid, sedative and anti-anxiety medication.

The World Health Organization reports that etizolam is six to 10 times more potent than diazepam for most of its effects.

It is currently not approved for use in the United States; however, it is on the market in Japan, Italy, and India under names such as:

  • Depas
  • Pasaden
  • Etilaam
  • Etizest
  • Sedekopan
  • Etizola

Etizolam is not regulated or controlled in the United States as an acceptable medication as of yet.

How Etizolam Is Abused

While etizolam is not on the market in America and you won’t find it in your local pharmacy or get a prescription from your doctor, you can obtain it over the Internet and through other channels.

This is highly dangerous as you can never be sure what exactly you are obtaining online.

Without more information and knowledge of etizolam’s potential effects, it is extremely risky to use without being under a physician’s care.

Etizolam is a tablet that is typically swallowed orally, but addicts are also known to crush and snort them. Because it is fairly new and not controlled in the United States, etizolam also contains none of the safety features to prevent abuse and tampering offered by some of the other more common and well-known prescription drugs.

Anxiety Disorder and Etizolam

Etizolam generally works the rest of the benzodiazepine family in that it targets the neurotransmitter gamma-amino butyric acid (GABA) in the brain, working to increase production and slow nerve impulses.

According to the Center for Substance Abuse Research, benzodiazepines are the one of the most prescribed depressant medications in America. They are often used to treat anxiety.

Etizolam works these other benzodiazepines; however, it seems to be more selective, binding to specific receptor sites in the brain and causing a more anxiolytic or anti-anxiety effect.

While etizolam is relatively unproven and under the radar, there has been a study done to attempt to determine its effectiveness on generalized anxiety disorder, or GAD. Because etizolam is more potent than Valium and seems to have fewer side effects, those suffering from GAD are interested in it.

While depressive and anxiety symptoms did seem to be improved with etizolam and side effects were less dramatic, daytime drowsiness being the most reported, other benzodiazepine side effects need to be taken into account as well.

Some of the biggest issues with benzodiazepines are their high risk for addiction and severe withdrawal symptoms. When taken correctly, drugs etizolam and Valium are meant as short-term solutions and not intended to be taken for long periods of time.

Risks of Abuse

Being similar to a benzodiazepine, etizolam carries many of the same risk factors. The potential for fatal overdose due to a suppression of the central nervous system is high. Benzodiazepines were implicated in 6,500 deaths in 2010 as published in the Journal of American Medical Association.

One of the major risks of benzo abuse is that of mixing it with another substance. The interaction of more than one substance creates even bigger risks and opportunities for overdose. Some of the other side effects of benzos and etizolam are:

  • Drowsiness
  • Mental confusion
  • Impaired coordination
  • Short-term memory loss
  • Decreased appetite
  • Headache
  • Blurry vision
  • Slurred speech
  • Vertigo
  • Decreased heart rate
  • Dry mouth
  • Nausea
  • Mood swings
  • Sleep issues
  • Muscle weakness

Etizolam and its benzodiazepine counterparts are intended for short-term relief of anxiety symptoms due to their extremely high potential for tolerance and dependence over time, which can lead to addiction. The National Survey on Drug Use and Health indicated that in 2010, seven million people used prescription drugs for nonmedical purposes, or in other words, abused them, in the past month.

By chemically altering the brain, these drugs create a tolerance when used over time. Users need more and more of the drug to obtain the desired effects.

Not only that, but the user’s brain then slows down its natural production of these chemicals; so when the drug is withdrawn, users have physical and emotional reactions that can be quite severe, including shaking, sweats, night terrors, nausea, trouble sleeping, headaches, irritability, and increased anxiety and paranoia. These chemical changes in the brain can take years to repair.

Getting Help

Those who suffer from anxiety disorders may be drawn to drugs etizolam regardless of the fact that they are still relatively untested and unproven.

On the surface, etizolam can appear to be more helpful with anxiety symptoms than other benzodiazepines and bring fewer side effects.

Many have already tried most of the more common benzodiazepine medications and developed a tolerance, thus increasing the appeal of new and different medications.

Group and individual therapy sessions can help uncover environmental and social triggers that can then be avoided or handled differently. While medication is an important tool, it is not the complete solution.

Dual diagnosis treatment centers focus on lasting health and well-being, not just treating the symptoms of a disorder.

Dual diagnosis care stays on the cusp of new research and strives to provide the best care possible.

If someone you know has become addicted to etizolam or other substances and also suffers from an anxiety disorder, specialized treatment in which both afflictions are addressed is vital.

Not all treatment is the same, and it is important for each individual to be assessed by a skilled professional and treated with a customized plan.

Withdrawal symptoms can be dangerous and detoxification should be monitored by a consulting doctor.

Treating addiction and anxiety simultaneously is imperative in helping to avoid relapse and promote lasting healing and recovery. Call now to talk with one of our admissions coordinators about how to move forward with your recovery.

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Etizolam: Potential Uses, Mechanisms, and Medical Controversies

Etizolam, Reviews, Sleep Effects, Uses & Warnings

Etizolam is a drug that is chemically quite similar to benzodiazepines.

It has been used in some countries to help treat anxiety and panic disorders, although it is not and has never been FDA-approved for medical use in many countries, including the United States.

What’s the story behind this drug, and why do medical practitioners tend to avoid it? Read on to learn more about this drug, how it works, and why many people consider it to be risky!

Disclaimer: This post is not a recommendation or endorsement for etizolam.

This medication has not been FDA-approved for any medical uses in the United States, and also cannot be legally prescribed or purchased in many other countries as well.

We have written this post for informational purposes only, and our goal is solely to inform people about the science behind etizolam’s effects, possible mechanisms, and associated risks.

What is Etizolam?

Etizolam is similar to benzodiazepines, although it has a slightly different chemical structure, making it a “thienodiazepine” (for the chemistry afficionados out there, this means its molecule contains a “thiophene ring” as opposed to a “benzene ring”).

It also has generally similar effects to benzodiazepines, such as reducing anxiety, alleviating convulsions, promoting unconsciousness and/or sleep (hypnotic/sedative effects), and relaxing the skeletal muscles [1].

Etizolam was originally developed in Japan during the early 1980s as a treatment for anxiety – especially for anxiety symptoms when they occur as a part of other major psychiatric disorders, such as depression, panic disorder, and generalized anxiety disorder (GAD). It also sometimes used for insomnia-related conditions, although this is relatively less common [1].

While this drug has been approved for medical applications in some countries – including Japan, Italy, and India – etizolam has not ever been approved by the FDA for medical use in the United States, where it remains “unscheduled”.

This means that it is not available to buy or use through a pharmacy – nor even can your doctor legally write a prescription for it.

At this point you might be wondering, if this drug has been approved in other countries, and is potentially effective, what’s up with its unusual legal status in other countries such as the US? In short, the answer to this has to do with the fact that etizolam is considered to have very high abuse potential [2, 3].

For example, etizolam is more easily absorbed and processed (metabolized) by the body. These chemical and molecular features cause its effects to be up to 6 times stronger than those of an identical dose of other chemically-related drugs, such as diazepam [1].

However, it’s in large part exactly because of this dramatically-increased potency that the medical establishment has some serious reservations about it [2, 3].

Anti-anxiety (anxiolytic) drugs – including benzodiazepines such as diazepam and opioids such as oxycodone and hydrocodone – are already some of the most widely abused prescription drugs out there, and their relatively widespread availability in countries in the US has played a major role in many ongoing addiction epidemics.

Since addiction is already a major social and public health issue with these types of drugs, you might be able to see now why the medical establishment would be hesitant to introduce a version of these drugs that is 6x stronger (and hence much more easily abusable).

Some researchers have reported that etizolam can sometimes be found and ordered online – but obviously this is not recommended. In addition to the well-established risks of abuse and addiction with this drug, buying unregulated substances online means you have no way of being sure what you’re actually getting, and could open yourself up to any number of significant dangers.

Mechanism of Action

Because etizolam is chemically structurally similar to benzodiazepines, its mechanisms are believed to be fairly similar as well.

The vast majority of etizolam’s main effects on anxiety and sleep most ly arise through the activation (agonism) of GABA receptors – particularly the GABAA receptor subtype [1, 2].

GABA is the primary “inhibitory” neurotransmitter used throughout the brain. Hence, medications that target this system can have therapeutic effects on symptoms anxiety by effectively “shutting down” the regions of the brain responsible for producing these feelings.

That’s a simplified explanation, anyways. If you want to dive into more of the details and intricacies behind the GABAergic system and how it works – or some of the more common medical drugs and other compounds or supplements that deal with this system – we recommend checking out our dedicated SelfDecode posts on GABA and natural ways to increase it.

Potential Medical Uses of Etizolam (UNAPPROVED)

The following sections describe some of the research that has been done on the potential medical applications of etizolam.

However, keep in mind that while there is generally fairly strong evidence in favor of etizolam’s efficacy in several health conditions, it’s where its safety is concerned that the issues arise.

Etizolam’s lack of safety is generally why the following uses have not been approved by the FDA. Therefore, the information discussed throughout this post is provided for informational purposes only.

Fortunately, if you suffer from anxiety-related issues, there are a large number of safe and legal medication options to consider, as well as many “natural” or “complementary” strategies that can potentially be tried in addition to conventional medical treatment. By discussing your health and treatment options with your doctor, he- or she will be able to advise you on the overall safest and most effective treatment approaches your specific medical needs.

1) Treating Anxiety

According to a few double-blind studies, etizolam has been reported to be relatively effective at treating anxiety and depressive symptoms in human patients [4, 5].

For example, etizolam is reported to reduce anxiety, and has even shown some signs of being a potentially effective antidepressant [6].

Similarly, one double-blind study with 30 female subjects reported that etizolam was generally effective at reducing anxiety and depressive activity [7].

When paired with other treatments, it may also potentially alleviate symptoms of panic disorder [8, 9].

Once again, while the effectiveness of etizolam is not really in question, it’s the lack of safety – such as the very high risk for abuse and addiction – where etizolam falls short. If you believe you are experiencing significant symptoms of anxiety, talk to your doctor about many of the legal and safer alternatives to etizolam to find out the best treatment option for you.

1) Pain

One early study has reported that etizolam may help alleviate pain for up to thirty minutes at a time, but that it is not the ideal form of treatment (especially compared to other pain-killing medications, which are generally more effective) [10].

In one study in young female patients, etizolam combined with a non-steroidal anti-inflammatory drug was reported to be a potentially effective treatment for tension-type headaches [11].

This drug has also been reported to be effective in treating pain related to irritable colon syndrome in patients with concurrent chronic anxiety conditions [12].

2) Vertigo

One early study has reported that low doses of etizolam reduced self-reported scores on evaluations of dizziness in patients with benign paroxysmal positional vertigo [13].

3) Elevated Blood Pressure

According to a single preliminary study, etizolam was reported to improve blood pressure indicators (systolic and diastolic blood pressure) in patients with elevated blood pressure (hypertension) [14].

Warnings and Cautions

In the few clinical studies that have been done with etizolam, it has been generally reported to be well-tolerated by most patients, and appears to produce relatively few side effects [15].

However, there have been several cases of toxicity, and the drug itself is also highly addictive [15, 3].

According to one report (case study), children may be at particular risk of negative reactions to etizolam, and may even show “paradoxical” reactions, such as stimulation- effects (even though this drug normally has the exact opposite effect [16].


The CYP2C19 gene creates a protein that metabolizes etizolam. Specific genetic variants (‘AG’ and ‘AA’ genotypes) for the single nucleotide polymorphism (SNP) rs4244285 are poor metabolizers of etizolam. This mutation is also sometimes referred to as the “CYP2C19*2” polymorphism [17].