- Understanding the Beneficial Effects of Pentadecapeptide BPC 157
- What Is BPC 157?
- How Does BPC 157 Work?
- Phase 1: Inflammatory Phase
- Phase 2: Proliferation and Repair Phase
- Phase 3: Remodelling Phase
- The Issue With BPC 157
- The Side Effects of BPC 157
- BPC 157 and Continued Research
- Is BPC 157 Right for You?
- BPC-157 Regeneration Peptide – The Science, Reviews and Dosage and How It Is Used
- So just what is BPC-157 and why should I take it?
- So why should you take the BPC-157 peptide?
- So is BPC-157 a bodybuilders dream?
- Via Injection
- How much should I take? – Finding the right dosage
- Joint Health and Rejuvenation
- Accelerates Bone Healing
- Protects against intestinal damage
- Protect against gut damage caused by NSAIDs
- Personal Final thoughts
- BPC 157: An In Dept Review and The Science Behind it
- How BPC-157 Works
- BPC-157 Side Effects
- Where to Buy BPC-157
- BPC-157 Dosage: What is the best Dosage for optimal results?
- How to Inject BPC-157 or Take It Orally
- Benefits of BPC 157 + Dosage, Side Effects & Reviews
- What Is BPC 157?
- How Does BPC 157 Work?
- Animal and Cell Research (Lack of Evidence)
- Inflammatory Bowel Disease
- Muscle and Tendon Healing
- Healing Burns, Cuts, and Broken Bones
- Protecting the Brain and Nervous System
- Ulcers and Gut Health
- Damage Caused By NSAIDs
- Drug Intoxication
- Balancing Blood Pressure
- Balancing Potassium Levels
- BPC 157 Side Effects
- Peptides Side Effects
- Cancer Risk
- How to Take BPC 157
- Limitations and Caveats
- BPC 157 Reviews & User Experiences
Understanding the Beneficial Effects of Pentadecapeptide BPC 157
Perhaps you can recall from your days of high school biology when the teacher briefly went over the importance of amino acids. Though the lesson that day could have expanded into a full-fledged college course, the final message was simple: amino acids are the building blocks of life on Earth.
Perhaps hailing from a distant realm within the universe, amino acids ly arrived here via comet or meteorite, and their general construction is rather simple. The key elements of an amino acid are carbon, hydrogen, oxygen, and nitrogen, hence why they’re considered the building blocks of life — you too are composed largely of the very same elements.
As powerful as a singular amino acid may be, these building blocks only grow more powerful after they’ve linked up with one another in a chain- sequence to form what’s known as a peptide.
Peptides operate by sending messages to cells that provide instructions regarding what those cells should become.
For instance, copper tripeptide is a specific peptide that heals wounds and calms inflammation.
Yet of all the peptides that endlessly work to service our body’s specific needs, one peptide known as Pentadecapeptide BPC 157 has recently caused a stir within the medical community.
Commonly referred to as BPC 157 and found originally within the human gastric juice in our gut, this peptide may serve us as the biohack-able body protective compound of the future. Let’s discuss this peptide in more detail to find out exactly what it’s capable of.
What Is BPC 157?
BPC 157 stands for Body Protein Compound 157, and it’s a sequence of 15 amino acids that are linked together to form a peptide.
Originally found as a protective peptide within our gut, BPC 157 is an intriguing peptide because it can’t be found in nature by itself.
When the body produces a compound that isn’t found naturally in the real world, it receives a special classification. For this reason, scientists classify BPC 157 as “synthetic.”
So why is BPC 157 causing such a commotion? And how can a peptide found in the gut even be classified as a body protective compound?
Simply put, research has led us to believe that BPC 157 can perform some incredible feats. Capable of acting as both a nootropic (a brain booster) and ergogenic (performance enhancing) substance, BPC 157 studies suggest this simple peptide can induce healing effects on various levels.
It can positively impact gastric ulcers and gastric lesions, trigger a vascular response to treat or aid in the recovery of ligament healing and tendon healing, and promote bone healing, wound healing, and muscle healing.
Of the many feats that BPC 157 may potentially achieve, however, its claim to fame is its ability to treat soft tissue injuries that involve skeletal muscles, tendons, and ligaments. The ability to quickly recover from such debilitating injuries is precisely where the scientific community would to take BPC 157 in the future.
How Does BPC 157 Work?
So how exactly does this peptide perform such incredible undertakings? It all makes sense when we dissect the three overlapping phases of healing that occur within the body after injury occurs. Let’s break these three phases down using an injured Achilles tendon as our example.
Phase 1: Inflammatory Phase
The inflammatory phase is the first phase of healing after an injury. In this phase, let’s pretend our Achilles tendon was extensively strained during an explosive sprint, leaving it feeling sore and painful. The inflammatory response will cause homeostasis to begin as the body seeks to maintain stable internal conditions.
Blood vessels will constrict and seal themselves off as platelets move in to clot and initially treat the wound. From there, these blood vessels will dilate and allow substances white blood cells, antibodies, enzymes, and other beneficial elements into the affected area to promote wound healing and stave off infection.
It’s during this phase that pain, swelling, heat, and redness will occur. This stage will last for anywhere from 1-5 days.
Phase 2: Proliferation and Repair Phase
After the body has had a chance to treat the initial symptoms of the injury and stabilize internal conditions, it will then begin rebuilding tissue through a cell migration process that attracts healthy cells to the injury site.
It’s also during this phase that blood vessels must receive a sufficient supply of oxygen and nutrients to produce healthy tissue through collagen organization in open wounds, which allows for the development of a new network of blood vessels to replace the ones that were damaged.
In this specific injury, it’s important to note that the Achilles tendon is heavily composed of extracellular matrix (a building material in the body) and tendon fibroblasts, another word for elongated tendon cells. In animal models, this is where BPC 157 has had an important impact.
After BPC 157 is administered, granulation tissue, or new connective tissue, grows quicker alongside tendon fibroblasts throughout the site of injury. As a result, researchers are exploring what more this peptide can do.
Phase 3: Remodelling Phase
The remodelling phase of the healing process is the final step on the road to recovery. During this phase, the wound has largely healed but may not be back to its normal strength for upwards of 2 years. According to Advanced Tissue, “during this phase, the dermal tissues are overhauled to enhance their tensile strength and non-functional fibroblasts are replaced by functional ones.”
It would seem then that BPC 157 is a healthy, simple, and risk-free opportunity to heal the body in quicker fashion than it would normally heal on its own. Yet as with many complex ingredients that claim to possess incredible properties, issues arise as we dig further into the data.
The Issue With BPC 157
If research has anything to say about BPC 157, it certainly isn’t saying much. And this is precisely why such a potentially helpful compound isn’t available on the market.
For instance, the studies of BPC 157 that tout it as a healing peptide are research and experimentation in animals. This means a test subject, such as a rat, was injected with BPC 157 and saw improvements over time. But there is a long and dynamic road between benefits seen in animal trials, and achieving the same results in clinical trials on humans.
Additionally, peptides are poorly absorbed by the body through oral ingestion, making injection the only suitable option for absorbing BPC 157.
This means that, should we ever decide to administer BPC 157 to the public, the process wouldn’t be as simple as taking a pill when we wake in the morning.
Instead we would need to visit a doctor, and receiving such clinical treatment is not an option for a large percentage of the population
And as we mentioned above, BPC 157 is considered a synthetic peptide because it does not occur in nature. This means that injection of BPC 157 poses a risk among competitive athletes, as this peptide would surely be considered a form of human growth factor. It possesses anti-inflammatory and regenerative properties.
The Side Effects of BPC 157
Let’s pretend for just a moment that you received an injection of BPC 157. It’s being used to treat the very same Achilles tendon we injured only paragraphs above, and you’re now hoping to heal in the fastest possible time frame. What side effects might you expect from such an injection?
While BPC 157 has no known side effects, this is largely because we don’t know how it interacts with humans. For instance, a study conducted on 32 healthy male volunteers who received enemas with this peptide showed no notable side effects. That being said, peptides in and of themselves can often produce unwanted side effects that include:
- Kidney and liver toxicity
- Feeling hot or cold
- Unusual hunger and weight gain
- Fatigue and dizziness
- Toxicity to fetuses
- Heart problems such as abnormal rhythms
- Blood pressure changes (increase or decrease, depending on the peptide)
While we may be able to make the claim that BPC 157 has no known side effects, the reality behind this statement is far less clear. Peptides can produce any number of unwanted side effects, and more research needs to be conducted before we can administer BPC 157 to the general public.
BPC 157 and Continued Research
Some of the world’s top researchers are currently working to determine whether BPC 157 contains life-changing properties. Much of this research comes to us from the University of Zagreb in Croatia.
It is here that studies surrounding the effect of this peptide on the human body are being executed each day. Those who have contributed to this cause include Sikiric P., Bojanic, Cerovecki, Klicek R., Sever M., Vukoja, Egr, Brcic I., Radic, Seiwerth, Pliva, Staresinic M., Anic T., Radic B., Rucman R., Novinscak T., Drmic D.
Is BPC 157 Right for You?
To determine if the healing effect of BPC 157 will benefit humans, we need more information. And most importantly, we need to continue to fund state-of-the-art research that seeks to answer whether or not BPC 157 is safe for use by the general public.
BPC 157 is an amino acid chain that possesses soft tissue-healing properties as well as nootropic benefits similar to that of other natural options on the market today. As a result, there may be no greater body protective compound that has the opportunity to benefit us all.
BPC-157 Regeneration Peptide – The Science, Reviews and Dosage and How It Is Used
With a few notable exceptions, such as for Doctor Who and the Hydra, the dream of rejuvenation for us mere mortals has always just been a pipedream.
But this has not stopped many people from trying out weird things to help them regenerate body parts and hopefully live longer, take Peter Thiel and Gavin Belson for instance, who are rumored to dilute their own blood with that of teenagers using blood transfusion methods.
In this case the parabiosis technique is research into longevity performed in the 1950s on mice, that is only now getting the modern research that it really needs.Unfortunately not everybody can afford to spend $40,000 a quarter for a supply of an adolescent’s young blood.
But don’t worry too much as there is good news as far as the regeneration of damaged muscles is concerned.
What if I was to tell you that there is a synthetic peptide out there that is able to repair the damage that is caused by inflammation, promote the healing of tendons of ligaments, and even speed up bone healing and protect the gut from damage caused by pain killer Nonsteroidal Anti-inflammatory Drugs (NSAIDs). You’d probably be thinking that I am talking about some far fetched wonder substance, but I’m not, a synthetic peptide that has been demonstrated to help the regeneration of tissue in rodents does indeed exist.
Well I’m guessing that you’d want to know the name of this peptide, its called BPC-157, really rolls off the tongue doesn’t it… Apparently the BPC in its name stands for Body Protecting Compound, and I’m guessing that there are at least another 156 of them out there.
First off, a side-note recommendation. Please DO NOT even think about taking BPC-157 for injury regeneration purposes until you have your essential bases covered.
This means you need to be taking collagen protein, some omega 3's if you aren't consuming enough fish, and a quality joint health supplement that contains essentials such as Cissus Quadrangularis (a miracle for me personally), turmeric, glucosamine and the . Only after this should you even think look any further.
So just what is BPC-157 and why should I take it?
all peptides it is composed of a chain sequence of amino acids (aa) (in this case a 15 aa chain). As it is not found naturally in the body it is known as a synthetic peptide.
If you are interested in the full 15 aa sequence, for whatever reason why, it is Gly-Glu-Pro-Pro-Pro-Gly-Lys-Pro-Ala-Asp-Asp-Ala-Gly-Leu-Va.
This synthetic peptide, which is derived from a protein called Thymosin beta 4 (TB-500), is also known by the names Bepecin, PL-10, and PL 14736.
So why should you take the BPC-157 peptide?
Well it appears to have all sorts of muscle and tendon mending properties, making it ideal to try if you have some type of sports related injury where the tissue needs to be rejuvenated. This may make it useful for the kind of injury that is often obtained from one of your workouts at the gym, perhaps even if the injury occurred a long time ago.
It appears to work by accelerating the rate of angiogenic repair.
Angiogenesis is a key dynamic process for wound healing as it allows the formation of new blood vessels from old ones and is involved in organization of a microvascular network.
It is also strongly associated with protection of the gastric tract, where it thought to meditate protection through interactions with the central and peripheral dopamine system.
So is BPC-157 a bodybuilders dream?
The use of BPC-157 has become a topic of great interest in the world of bodybuilding. Where its potential to heal damaged joints and muscles, and to enable a quick recovery and return to the gym are deemed ideal for those carrying out high intensity exercise regimes.
A case study by an athlete going by the name of ‘Bouncer’ on the superiormuscle.com forum looks at the use of 250 mcg per day of sub-q into the stomach, using a two month supplyBouncer opened the thread by mentioning that someone reported that after just one week of using BPC-157 they had seen an astounding improvement in their right hip.
The person reported that the pain had gone from it and that after four injections he was able to smash out things at the gym that his injury had previously prevented him doing.Bouncer did not find similar findings within a week, and suggested that the injection may work locally as opposed to systematically, despite what the research says.
After two weeks he reported improved sleep quality and that he was not feeling as tight as previously.
After one month he suggested that the use of the peptide may indeed be beneficial, but perhaps not as effective as taking TB-500. At this point he increased the dose to 500 mcg. He also reported that the use of BPC-157 seemed to have a positive impact on the effects of MK-677.
At a dose of 375 mcg, Bouncer reported getting headaches and having a queasy feeling about 10 minutes after taking the injection. His overall findings seem to be quite inconclusive.
There is also an interesting thread on the use of BPC-157 in the anabolicminds.com forum.
In this thread, people suggest that as it is relatively inexpensive and that it may be one of the best healing peptides around that it is great for stacking with GHRP/H.
Some of the things that the original poster of this thread mentioned was that in rats the peptide has been reported to help heal torn quadricep muscles, damaged muscles and detached tendons; improve the speed of recovery from torn muscles; protect organs; heal ulcers; enhance the healing of ligaments; and to improve tendon to bone joint healing.
Posters to the forum suggest using a four week cycle with a two week rest period.
The reported results of the effectiveness of BPC-157 seem to be somewhat mixed.
The most studied and most recommended way to consume BPC157 is via a intramuscular or subcutaneous injection. This means either directly into the muscle (bodybuilding lore claims to aim for a close to the injury as possible), or underneath the fat for a general systematic effect.
Most synthetic peptides are difficult if not impossible for them to be absorbed by the body if taken orally, therefore nearly all of the research into it (using rodents) is performed by giving an injection.
Although given by injection in scientific research studies it has been shown to be a relatively stable peptide ex vivo and can last for 24 hours in the stomach’s acid.
It is not quite as stable in plasma, where just 36% remains intact after a one-hour period. There have been two rodent studies showing that it might be effective orally, but more studies are necessary as it may not be absorbed into the bloodstream if consumed this way. Many users in bodybuilding forums are still claiming benefits from consuming orally, but this may or may not be placebo.
Update: A company is now making BPC and preserving it in capsule format. We reached out to them and they gave a discount code to save 15% off of orders. Just use code VITAMONK15 and order here.
How much should I take? – Finding the right dosage
This depends on your body weight.
All of the research carried out so far has used rodent studies, the rats and mice are usually injected with an effective dosage thought to be around 10 μg (mcg) per KG, in humans this is thought to be around the equivalent loading of 1.
6 μg per KG in humans, so if you are: 60 KG (132 lb.) then your ideal daily BPC-157 oral dose would be 96 μg (mcg)70 KG (154 lb.) => 112 μg80 KG (176 lb.) => 128 μg
90 KG (198 lb.) => 144 μg
With this said, those doses are a little on the low side of the doses taken by bodybuilders in the forum (again, this is bro-science experimentation, NOT medically studied dosages). Users here are regularly taking 250 mcg up to 500 mcg a day.
There are even those taking super high doses of BPC-157 (1mg/day) without reported negative side effects. Again, we are definitely not recommending this. You should definitely talk to a doctor before experimenting with this.
It's unknown territory.
Joint Health and Rejuvenation
Fibroblasts are a specialized type of cell found in connective tissues. These cells are involved in the creation of collagen.The use of BPC-157 is thought to speed up the growth and spread of fibroblasts and to increase rates of oxidative resistance. In addition to its effects upon fibroblast production.
It also affects F-actin formation (which is involved in the spreading of fibroblasts).The peptide has also been successfully used to increase the rate of collagen reformation following surgery.
The above findings go a long way to explaining how the administration of BPC-157 is able to promote healthy tendon and ligament healing.
Accelerates Bone Healing
As gastrectomy is related with derogatory bone conditions such as osteoporosis it is no surprise that the use of BPC-157, with its well-known fracture and wound healing aspects, is associated with improved bone health.
Research using rabbits has shown that the peptide is able to significantly improve healing related to osteoperiosteal bone defects over a six-week (1.5 months) period, especially following an autologous cortical graft or the local application of bone marrow.
Furthermore, the number of animals that healed was much greater in the experimental than what occurred in the control group. So it seems that the use of BPC-157 can both increase the rate and the frequency of recovery from bone damage.
Although the above experiments took place in lagomorphs the authors are very excited about its potential use in the management of bone related impairments that may occur in human patients.
Protects against intestinal damage
One of the most exciting aspects of BPC-157 is its potential for protecting the intestines from inflammatory damage.
When toxins were given to rats to mimic the effect of intestinal inflammation, the use of this peptide reduced the amount of visual markers known to be associated with intestinal gut damage.
The direct injections of BPC-157 into specific parts of rats is thought to help repair intestines through impacting nitric oxide signaling.
It can also help to overcome problems related to short gut (Short Bowel Syndrome: SBS). This condition often leads to malnutrition and dehydration because of increased incidence of diarrhea. The use of this peptide can help to make this problematic condition much better. It is also thought to be able to help repair damaged tissues caused by inflammatory bowel disease (IBD).
This peptide is known to impact dopamine levels, though there is as yet no evidence for the direct binding of dopamine receptors. It is therefore thought that its main action with regards to dopaminergic neurotransmission is ly to be through the antagonism of dopamine itself, and this interaction is thought to reduce the effects of amphetamine on compulsive behaviors.
Protect against gut damage caused by NSAIDs
Although they act great as painkillers one of the big problems with NSAIDs is that they can be toxic to the gut, this frequently leads to ulcers and an irritation of the bowels.
BPC-157 is able to act as an anti-ulcer peptidergic agent and has been put forward as an NSAIDs antidote as it is beneficial against damage caused by mediated lesions in the gastrointestinal tract, brain, and the liver, and is able to counteract symptoms associated with the taking of aspirins, such as bleeding.
Present research suggests that BPC-157 does not have toxic effects itself and is thus thought ly to have very high safety in its use against gastric damage caused by NSAIDs.
As BPC-157 is able to reduce cell damage in the hippocampus of rats it very ly confers neuroprotective effects. It can help protect the brain tissue from damage when rats are given cuprizone (a toxin that scientists use to mimic the effects of schizophrenia and multiple sclerosis) it is thought that actual protection of the nerves may actually occur through intestinal processes.
Personal Final thoughts
My own point of view is that this is an exciting new compound that may have major positive benefits for people who have suffered from injuries, such as which may occur during gym fitness workouts and in exercises using hand equipment, such as tennis elbow, strained and torn muscles, joint issues, and general sprains.
It also seems to have numerous positive aspects for gut health. Overall, it looks to be ideal for serious post exercise recovery problems.
It is hoped that you find this information on the wonder peptide BPC 157 to be of great use, if you have any questions or have tried it yourself and would to leave some feedback points of your own, then please feel free to leave a comment below.
Due to the limited amount of high quality scientifically researched information available on this product VitaMonk does not endorse the use of BPC-157.
Although we find its use of great interest, especially for bodybuilders, it has definitely not been fully tested and people who use it do so at their own risk.
As a result, it is not a product that VitaMonk will offer for sale in the future.
The information in this article is provided as an information resource only, and is not to be used or relied on for any diagnostic or treatment purposes. This information is not intended to be patient education, does not create any patient-physician relationship, and should not be used as a substitute for professional diagnosis and treatment.
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BPC 157: An In Dept Review and The Science Behind it
BPC 157 is one of many peptides available on the supplement market. However, what sets it apart from its competitors is the fact that it’s extracted from a gastrointestinal protective protein.
So far, only rodent studies have been conducted on BPC-157 and they all agree on one thing; BPC-157 has powerful protective properties that encompass other areas of the body besides the stomach.
Research data shows that BPC-157 can help heal ulcers, intestinal damage, joint, and bone damage, as well as treat a number of inflammatory disorders. It has even been shown to heal damaged organs and influence the brain.
In certain research studies where PBC-157 was administered to poisoned or surgically damaged rats, the peptide was shown to have incredibly protective properties.
Although additional research needs to be conducted in order to confirm BPC-157’s ability to heal multiple levels of the body, there’s enough evidence to confirm that it has a positive effect on angiogenesis growth factors. Angiogenesis refers to the process through which blood vessels are developed in the body and it plays an important role in healing damaged tissue.
All of this is good and well, but it’s ly on animal studies. Additional research needs to be conducted to show if BPC-157 has the same effects on humans.
How BPC-157 Works
Research on BPC-157 has been on-going since 1991 and results thereof indicate that the peptide has the ability to repair damaged teeth, bones, muscles, tendons, and even intestines.
This data is in-vitro lab tests as well as in-vivo studies conducted on both rodents and humans. Some of the human trials involved injecting the peptide under the skin (subcutaneously) and into the muscles (intramuscularly).
SuppVersity published an article on BPC-157 which showed that the peptide has the following healing benefits:
- Heal’s tendons and bones in a way that rivals conventional surgical methods;
- Stimulates the healing of the bones and ligaments by promoting improved cell survival and cell migration. These results are rodent research on mice that were affected by an Achilles tendon rupture. The mice had the peptide administered to them through drinking water;
- It has the ability to offset the gut-damaging effects that you get from taking NSAIDs Advil and Ibuprofen. Scientists were so amazed at the results that they called BPC-157 an antidote to NSAIDs;
- Mice with inflammatory bowel disease healed within days of orally ingesting the peptide;
- It has been shown to heal periodontitis in mice. In fact, BPC-157 is so effective at healing this condition that scientists are considering the possibility of making it a viable treatment for it;
- It healed and reversed systemic corticosteroid-impaired muscle healing in mice. These results happened after the mice took one dosage of the peptide per day for 14 days;
- It fast-tracked the healing of segmental bone defect in rabbits.
Scientists recognize BPC-157 as a “stable gastric pentadecapeptide”, due to its ability to bring equilibrium to human gastric juice. It has also been shown to treat ulcers, heal inflammatory bowel disease as well as the upper and lower GI tract with remarkable efficiency. The best part is that BPC-157 doesn’t come with any adverse side-effects!
The abovementioned studies all indicate that BPC-157 works great when it comes to fast-tracking wound healing. Through its positive interaction with the Nitric Oxide (NO) system, BPC-157 helps heal wounds by building up the blood vessels and protecting the endothelial tissue.
It also promotes gene expression while specifically targeting genes that are responsible for collagen formation, generation of growth factor and cytokine. It can also heal intestinal anastomosis and short bowel syndrome. All of the abovementioned conditions are known to affect sufferers of bowel inflammation, diarrhea, constipation, and gut pain.
These positive effects have been observed even in conditions that had reached advanced stages.
Below you will find a video about BPC-157 and TB-500 for healing purposes. A lot of questions are being answers about what BPC-157 is and how you can use it. This is, of course, all anecdotal and user experience.
BPC-157 Side Effects
So far, no side effects have been observed from the use of BPC-157.
Although there have been reports of mild sickness or nausea among users, both effects were later attributed to being the result of the body acclimating itself to the peptide.
Aside from that, BPC-157 is very safe and has incredible healing properties that positively affect the organs. Even clinical phase 2 research results have shown no side effects.
Where to Buy BPC-157
The best way to source BPC-157 at the moment is through one of the many online suppliers that exist. However, as with any online purchase, you’ll have to do some research and be careful. You’ll most ly find it advertised on cheesy websites that don’t really look much, because technically no-one’s allowed to sell this stuff for human use.
There’s also no telling what form of BPC-157 is the best, but it’s safe to say that any website that comes clean about the peptide’s status is trustworthy. Look out for a notice on the website that says “sold only for lab chemical research.”
BPC-157 Dosage: What is the best Dosage for optimal results?
the research conducted on BPC-157 thus far, a single dosage of 1-10 mcg per kg of body weight taken once daily is the best way to go.
This brings the most systematic benefit for the body and translates to 200-800 mcg per day depending on the individual’s body weight.
Most people who’ve taken it say they derive the most benefit when they take it in dosages of 250-350 mcg twice per day, which translates to 500-700 mcg per day in total.
Below you will find a simple but effective BPC-157 dosage plan for healing purposes. This is for people that are willing to recover from a insury a pec tear or have bad elbows from training hard in the gym or even in other sports Golf and Tennis.
This shows that there’s no one size fits all approach when it comes to the dosage recommendation, and it all depends on the individual.
It’s worth mentioning here that some of the mild reactions mostly happened in cases where a higher dosage of the peptide was taken. However, they only lasted for a few hours at a time and dissipated with a lower dose.
So proceed with caution and if you experience any side-effects reduce the dose until you find something that works for you.
In this video Coach Trevor from Enhanced Athlete will tell you how to use BPC-157 and TB-500 for healing a pectoral tear.
How to Inject BPC-157 or Take It Orally
As previously mentioned, BPC-157 has a systemic effect on the body.
The subcutaneous method is the easiest and least painful because it involves inserting the injection under the skin, preferably in an area as close to the injury or pain-point as possible.
Alternatively, you can inject BPC-157 intramuscularly, which means stabbing the needle right into the muscle. Needless to say, this is a very painful method, especially when you consider that it’s typically done in an area that’s close to the injury as well.
By far the easiest method is to spray the peptide into your mouth. Just make sure to hold the liquid inside your mouth for about 90 to 120 seconds before swallowing.
If you’re okay with needles then you can always opt for a subcutaneous needle instead.
All you have to do is pinch an area of the skin as close as possible to the injury, making sure to angle the needle so that it sort of “slips” underneath the area of the skin that you’ve pinched and not directly onto it.
This can be a bit difficult to do so it might be a good idea to get someone to help you out with it. Remember to use an alcohol swab to clean the area of the skin that you’re about to inject, as well as the rubber stopper before and after the injection.
The most painful yet equally effective method that you can choose is the intramuscular injection. Similar to subcutaneous injections, this method requires that you clean the rubber stopper and the part of the skin that you’re about to inject with an alcohol swab.
However, you’ll be stabbing the skin with the needle instead of working it in you would with the subcutaneous method. Keep in mind that you’ll be administering the needle as close to the affected area as possible, which might add to the pain. But, thinking happy thoughts have been shown to help in some instances although we can’t guarantee the efficacy of that method.
On the bright side, this method will enable the peptide to work quickly and accelerate healing.
After reading all the information on this article, you’re probably wondering to yourself why no-one has told you about this incredibly healing peptide yet.
One of the problems is that BPC-157 is not patentable which means the pharmaceutical industry cannot make money from it. Even your doctor probably doesn’t know about it because it’s not being marketed, and since it’s not regulated by the FDA, BPC-157 technically isn’t allowed to be sold for human use. And this is regardless of the fact that BPC-157 is a natural gastric juice peptide.
The good news is that BPC-157 hasn’t been banned by sports governing bodies WADA and USADA. This means that athletes and bodybuilders can still take it and benefit from its healing properties.
But the lack of long-term human studies on BPC-157 means there’s a possibility of it becoming prohibited by these governing bodies in the future.
Nevertheless, BPC-157 is pretty safe to take, as no adverse side effects have been shown in the short-term clinical trials that have been conducted so far. So if you have a problem with gut inflammation, injuries or any of the conditions mentioned in this article, then you might want to consider it as a form of treatment.
- Tendons Healing
- Fast Acting
- No Side Effects
Benefits of BPC 157 + Dosage, Side Effects & Reviews
BPC 157 is a short peptide chain – essentially a piece of a protein. Its regenerative potential attracted scientists, who are starting to investigate if this peptide may promote muscle and wound healing and counteract the toxic effects of common painkillers. Read on to learn what the science does, and doesn’t, say about BPC 157.
What Is BPC 157?
BPC is a protein found in stomach acid and discovered in the ‘90s. BPC 157 is a 15-amino-acid-long fragment of this protein that is synthetically produced .
Some studies refer to BPC as “body protection compound,” hinting at its therapeutic potential. Scientists consider it a blueprint for an entirely new class of organ-protective/healing drugs, but research is still in the early stages [2, 1, 3].
How Does BPC 157 Work?
BPC 157 ly promotes muscle and tendon healing by triggering the formation of new blood vessels – a process called angiogenesis (by increasingVEGF). This explains its regenerative potential and why it might also help heal wounds, cuts, and other types of damage in the body [4, 5].
By increasing new blood vessels, it might help with IBD, in which healing of the inflamed gut lining is slow .
Additionally, BPC 157 may promote wound and tendon healing by blocking the growth-inhibiting effects of a specific molecule (called 4‐hydroxynonenal) .
It might specifically help tendons heal by causing tendon cells to make more receptors for growth signaling molecules. This, in turn, allows the tendon cells to grow and move during injury repair, speeding up the process [8, 9].
It can also reduce inflammation, which is probably involved in its effects on wounds, ulcers, and tissue protection [10, 11].
BPC 157 can also influence the activity of neurotransmitters serotonin and dopamine. In turn, it might help with depression, seizures, pain, and may even promote gut health. More research is needed to understand exactly how it works in the brain [12, 13, 14, 3].
Lastly, it can increase the production of nitric oxide (NO), which lowers blood pressure and helps to reduce the effects of high potassium levels [15, 16].
- May promote healing and tissue regeneration
- May reduce inflammation
- May protect organs from toxins and damage
- No published, peer-reviewed studies in humans
- Unknown safety profile
- May interact with other drugs and medications
- Potential conflicts of interest for scientists doing the research
Animal and Cell Research (Lack of Evidence)
No clinical evidence supports the use of BPC 157 for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based research, which should guide further investigational efforts. However, the studies listed should not be interpreted as supportive of any health benefit.
Inflammatory Bowel Disease
There are numerous references, both online and in published scientific studies, to BPC 157 being safe and/or effective in clinical trials of inflammatory bowel disease (IBD). However, results from such studies do not appear to have been published or peer-reviewed.
Some studies in humans with titles suggesting they tested IBD – falsely cited even in the scientific literature – were in fact performed in healthy people (see “Side Effects” section below) [6, 17, 18].
In rats with IBS, the peptide decreased inflammation [6, 11, 19].
Muscle and Tendon Healing
In rats with injuries in their Achilles tendons, injections with BPC 157 helped the tendons to heal almost completely, whereas control rats didn’t make full recoveries [7, 5, 20].
Similarly, peptide injections improved muscle healing for rats whose muscles had been cut or crushed. This effect even held true when rats were also treated with corticosteroids (steroid drugs hydrocortisone), which can slow the healing process [21, 22, 23].
Healing Burns, Cuts, and Broken Bones
In mice with burns, creams containing BPC 157 accelerated the healing process, even in those simultaneously given corticosteroids [24, 25, 26].
BPC 157 also helped cuts heal in mice and in rats. It was effective even in diabetic rats; diabetes can make it harder for the body to heal wounds [27, 28].
Injections with the peptide also spurred the healing of broken bones in rabbits .
Protecting the Brain and Nervous System
Rats given BPC 157 injections after suffering traumatic brain injury had less brain damage, and rats injected with BPC 157 before brain injury were more ly to stay conscious and less ly to die .
In rats with nerve damage in their legs, BPC 157 injections helped the nerve cells regrow and heal .
The peptide also protected mice from drug-induced seizures .
It might also positively affect mood. In one study, BPC 157 injections decreaseddepression– behavior in rats. This effect was comparable to that of conventional antidepressants .
Ulcers and Gut Health
Injections of BPC 157 helped to heal stomach ulcers in rats. It also protected the rats’ intestines from damage due to toxins alcohol and helped heal gastrointestinal fistulas – abnormal openings in the digestive tract that cause fluids to leak [32, 34, 35, 36, 11, 37, 11].
In one study, BPC 157 injections reduced inflammation in rats with both stomach ulcers and arthritis .
In rats with an inflamed esophagus – the tube that goes from the throat to the stomach – the peptide also reduced inflammation .
Interestingly, BPC 157 might act on the gut-brain axis, helping to soothe the stress response “from the inside out” [3, 1].
Damage Caused By NSAIDs
NSAIDs (non-steroidal anti-inflammatory drugs) include over-the-counter (OTC) pain medications aspirin and ibuprofen. Although generally safe if used as directed, these drugs can cause damage to organs the stomach and liver if taken in high doses [39, 40].
BPC 157, either injected or consumed in drinking water, reversed these toxic effects in rats given NSAIDs [40, 41, 42, 38].
BPC 157 might be useful in counteracting drug intoxication.
In rats, BPC 157 given with morphine made the morphine less effective – that is, the rats given both morphine and the peptide were more sensitive to pain than those given just morphine. However, rats given both were still less sensitive to pain than rats given nothing at all .
It also decreased abnormal behavior in rats given amphetamines. This peptide might counteract the chemical imbalances amphetamines can trigger, especially on the dopamine system [43, 44].
BPC 157 by itself may be a mild painkiller. Rats injected with the peptide experienced less pain to pinching and similar unpleasant stimuli. Notably, this study was testing the effects of BPC 157 alone, not in combination with pain-reducing drugs (i.e. morphine, discussed above) .
Balancing Blood Pressure
In rats, BPC 157 had a stabilizing effect on blood pressure: in those with chemically induced high blood pressure, peptide injections decreased blood pressure. However, in rats given L-arginine, which can abnormally lower blood pressure, BPC 157 increased it .
Balancing Potassium Levels
Hyperkalemia is when blood potassium levels become too high. It’s usually the result of kidney disease, and it can cause muscle weakness, fatigue, irregular heart rhythms (arrhythmias), and even death .
In one study, untreated rats with hyperkalemia died within half an hour. But rats given injections of BPC 157, either before or immediately after getting hyperkalemia, survived and had fewer symptoms .
BPC 157 Side Effects
Keep in mind that BPC 157 is a practically unresearched substance. Due to the absence of clinical studies, its safety profile in humans is unknown. Talk to your doctor before supplementing with this peptide and report any side effects that you notice after taking it.
In one study, 32 healthy male volunteers were given BPC 157 enemas and reportedly had no notable adverse effects. However, important details dosage aren’t readily available, and enemas are not the typical route of administration [17, 18].
Additionally, these results appear to have only been presented at conferences and have not yet gone through peer review [17, 18].
As there aren’t many solid scientific studies in humans it’s unclear exactly what the side effects of BPC 157 are. Animal studies generally report no obvious adverse reactions, though that doesn’t exclude the possibility of unnoticed effects or different effects in people .
Peptides Side Effects
Peptides used to increase muscle mass come with numerous unwanted effects. While there are no data to say for sure whether BPC 157 will cause the same, some of the side effects associated with using peptides include [48, 49, 50, 51, 52]:
- Kidney and liver toxicity
- Unusual hunger and weight gain
- Feeling hot or cold
- Blood pressure changes (increase or decrease, depending on the peptide)
- Heart problems abnormal rhythms
- Fatigue and dizziness
- Toxicity to fetuses
Additionally, many peptides are known to interact with medications. As such, it’s always best to ask a doctor before taking any peptide [48+].
Growing new blood vessels is useful when it comes to injury repair, but it can be dangerous when it comes to cancer. While no studies suggest that BPC 157 increases the risk of cancer, its ability to increase blood vessel growth may feed existing tumors and cause them to spread .
On the other hand, BPC 157 may actually be beneficial for reducing muscle wasting in cancer patients. Research is currently underway .
How to Take BPC 157
BPC 157 can be taken orally or via injection, either subcutaneous (under the skin) or intramuscular (directly into the muscle).
Of course, injections of any substance carry their own risks and require medical supervision.
Anecdotally, several users report cycling BPC 157, while others use lower doses over extended periods of time (> 6 months).
Because there are no peer-reviewed clinical trials testing BPC 157, there is no proven dose. Additionally, the FDA has neither approved this drug for any conditions nor established an official dose. Users and supplement manufacturers have established unofficial doses trial and error.
In rats and mice ingesting BPC 157 in their drinking water, the typical dosage ranged between 10 nanograms to 10 mcg (micrograms) per kg. The studied dosage for injections in rodents was within the same range [55, 43, 45, 16].
This is equivalent to a maximal dose of around 600 mcg for a 60 kg (132 lbs) adult human.
However, doses often don’t scale between species. Some users report taking lower doses (~250 mcg/day) for pain relief.
Remember that BPC 157 hasn’t been studied in humans. There is no way to know what the safe and effective dosage would be before clinical studies are carried out.
Additionally, many of the animal experiments were done using injections directly into the abdominal cavity, rather than under the skin or into the muscle.
Limitations and Caveats
First and foremost, all of the studies discussed above were performed in animal models and/or in cells in dishes. While such studies can be valuable, mice are different from humans, so it’s important not to assume that a treatment will have the same effect in both species.
Additionally, most of the studies were performed by the same few labs, with the same people listed as co-authors in many studies.
While it isn’t uncommon for a lab that finds an interesting avenue of research BPC 157 to “take it and run with it,” this does increase the lihood for bias, particularly when some of the researchers hold patents on the compounds being studied [56, 57].
BPC 157 Reviews & User Experiences
The opinions expressed in this section are solely those of BPC 157 users, who may or may not have medical or scientific training. Their reviews do not represent the opinions of SelfHacked. SelfHacked does not endorse any specific product, service, or treatment, especially those that haven’t been studied in humans.
Do not consider user experiences as medical advice.
Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare providers because of something you have read on SelfHacked.
We understand that reading individual, real-life experiences can be a helpful resource, but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified healthcare provider.
Generally, users of BPC 157 report positive effects. In professional muscle forums, users report that the peptide can help with healing injuries, soreness, inflammation, and tendonitis. One user said, “I give it all the glory.”
Some users have reported getting no noticeable benefit from using the peptide, and many expressed concern over the high cost and confusion at how to use it and what the dose should be. Some also reported unpleasant side effects, primarily constipation. Others were concerned about the long-term safety risks, given that this peptide has not been studied in humans.
Additionally, some users speculated that companies have mislabeled peptides that are cheaper to manufacture as BPC 157, urging caution for others looking to purchase it.