Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage

The Ultimate Fat Loss & Muscle Building Supplement Has Arrived: C3g (Cyanidin 3-Glucoside)

Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage

July 18, 2018 Andy Yingling Collaborator C3G forces nutrients into muscle instead of storing them as fat by triggering “nutrient partitioning”, a novel technology found in new LIPO-DREX?.

Nothing drives people into the gyms, or nutrition stores, more than the pursuit of losing fat, and building muscle, in an effort to attain the coveted ripped and muscular look.

But can they be done simultaneously – losing fat and building muscle? New investigations suggests they can, exciting new research on an ingredient called Cyanidin-3-Glucoside, or “C3G” for short.

Related: Maxon: The Science of Building Pure Strength Through Supplementation

Here, in this brief article, I'd to explain What is C3G; How it works; What the science says about it; and Whether you should be using it? for body re-compositioning.
Introducing the all new LIPO-DREX with C3G – The nutrient partitioning thermogenic fat burner by iSatori.

What is C3G, or Cyanidin 3-Glucoside?

You heard it here first – Cyanidin-3-Glucoside or C3G – for its positive effects on bodyfat losses and simultaneous lean muscle fullness/improvement. This is due to a concept that's been around awhile in the scientific community, but not really all that well understood, called “nutrient partitioning.

” (We?ll get back to this concept of “nutrient portioning” later on and why it's so vitally important to us).Cyanidin 3-Glucoside (C3G) is a special purple colored pigment from the anthocyanidin group.

It's found primarily in the skins and colored regions of dark purple fruits, grains corn, and berries such as blackberries, aronia berries and a few others.Although C3G is bound to glucose (the “glucoside” part), its calorie content is negligible, even in the highest doses.

Standardized extracts of C3G range from minimal to upwards of 90%, therefore a mixture or blend of C3G-containing substances are optimal to ensure adequate levels to replicate therapeutic doses recommended by research.

How does C3G work?

In simplistic terms, C3G works as a “nutrient partitioning” agent. In other words, C3G helps to divert nutrients consumed away from fat cells and drives them into muscle cells. Now, if this doesn't sound a bodybuilder?s dream, as the ultimate transformation agent, then you must be living on another planet.

C3G does this by activating the master cell regulator, called AMPK (adenosine-monophosphate-protein-activated-kinase), which in turns signals an enzyme called Lipoprotein lipase (or LPL) to deactivate in the fat cells and activate within the muscle cells; which thereby directly impacts adipocytes (fat cells) in a way that causes them to reject the storage of fat from food calories while simultaneously triggering muscle cells to “request” additional nutrients. (See fig. 1). Simply put, C3G drives the nutrients you get from food (calories mainly from fat and carbohydrates), away from the fat cell and redirects them into the muscle cell.

Figure 1

What does the science say about C3G?

Cyanidin 3-Glucoside was first investigated for its potential insulin management properties. Later, it was investigated for weight loss effects, prevention of obesity and surprisingly, was discovered that it could increase muscle mass.

Again, this is why C3G has been affectionately coined “the ultimate body transformation agent.”In the most conclusive study (Tsuda, T et al.

), animals fed an obesogenic diet (high fat, high sugar), where one group was provided with Cyanidin-3-Glucoside (C3G from purple corn), and the other group did not receive the C3G.

The results of statistical differences between the groups were very impressive with regard to bodyweight (bodyfat and muscle mass). Paraphrased from the study, one researcher was quoting as saying, “fat cells were shrinking and muscle cells were growing.” these results.

C3G Supports Lean Muscle Mass Growth:

Science on C3G has revealed multiple peer-reviewed studies that it may be able to reduce bodyfat and actually increase lean muscle mass, during periods of controlled overfeeding. Reason is, according to one study (Wei, X, et al.

), C3G is a potent AMPK activator and thereby produces a downstream effect of increasing glucose and lipid update into myocytes (tubular cells inside our muscles).Further research (Luo, X; and Oak, MH, et al.

) has revealed that in smooth muscles, C3G can exert a pro-inflammatory effect and prevent subsequent damage and oxidation, allowing for the muscle to repair and recovery sooner after exercise. What was most interesting, however, is in the Tsuda study, the more calories that were consumed in the test subjects, the more lean mass that was gained.

In some cases, fat loss was still observed even in the case of overall weight gain, meaning that fat loss and muscle gain occurred simultaneously. In fact, the study subjects who did not received the C3G, yet fed the high fat/high sugar diet, actually became diabetic and obese.
Click here now to order Lipo-Drex from iSatori.

C3G Reduces Adipose Tissue (Body Fat):

Additional research from Tsuda, showed that subjects taking the Cyandin 3-Glucoside benefited from reduced adipocyte (e.g., fat cell lining) inflammation and an increase in secreted adiponectin levels.

Through AMPK activation, a different mechanism of action, lipoprotein lipase (LPL) enzymes are activated in muscle cells and suppressed in fat cells with C3G administration, in a way that caused fat cells to literally “reject” the storage of fat from food calories, while simultaneously triggered muscle cells to “request” additional nutrients. This is why subjects gained muscle and lost bodyfat, at the same time.In a more recent study, Scazzocchio B, et al showed that C3G can also exert anti-diabetic effects via stimulation of the GLUT4 transporter activity in fat cells, and reducing retinol binding protein 4 (RBP4) expression. I appreciate these are simply technical phrases for “efficient glucose disposal.” Startling to the researchers, these results were reported to rival that of the diabetic drug Metformin®.Point being, contrary to what would normally happen, C3G is a potent inhibitor of fat cell enlargement and a decrease in fat cells size, despite large amounts of high-sugar calories consumed.

The Final Piece of the Fat Loss-Muscle Building Puzzle

I have a hunch this won't be the last time you hear or read about “nutrient partitioning.” A novel concept that produces two diametrically opposing biological goals – simultaneous bodyfat loses and muscle gains.

And rarely do I find myself compelled by such impressive data, that I've discovered from C3G, that I would profess such a bold statement – calling it “The Ultimate Body Transformation Agent.”

But in this case, I firmly believe the data speaks for itself.

It's for these reasons we've created a “super C3G” ingredient, combining three forms of cyandin-3-glucoside, to produce the most profound effect in “nutrient partitioning.

” it's called C3G-Max™; made from Aronia, Purple Corn and Blackberries, standardized for potency and purity of cyandin-3-glucoside.

C3G-Max can only be found in LIPO-DREX™, a new novel nutraceutical from iSatori designed to impart the strongest “nutrient partitioning” available and help users, along with exercise, lose bodyfat and increase muscle mass, at the same time – to achieve the coveted lean and muscular physique.

Scientific References on C3G

Grace MH, et al Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton . Phytomedicine. (2009)
Luo X, et al Cyanidin-3-glucoside suppresses TNF-?-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling .

Mol Cell Biochem. (2012).
Oak MH, et al Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK .Br J Pharmacol. (2006).
Scazzocchio B, et al Cyanidin-3-O-?-glucoside and protocatechuic acid exert insulin- effects by upregulating PPAR? activity in human omental adipocytes .

Diabetes. (2011)
Sasaki R, et al Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol. (2007)
Tsuda, T et al.

, ?Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice? Journal of Nutrition (2003) July, 133(7):2125-30.
Tsuda T, et al Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes . Biochem Biophys Res Commun.

(2004)
Wei X, et al Cyanidin-3-O-?-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity . J Sci Food Agric. (2011).

Source: https://www.tigerfitness.com/blogs/supplements/c3g-cyanidin-3-glucoside-lipodrex

Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage

Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage

Cyanidin 3-glucoside (c3g) is a natural pigment found in a variety of dark-colored fruits, plants, and vegetables.

It’s gaining popularity due to the potent antioxidant and anti-inflammatory effects.

Scientists are investigating the effects of c3g on diabetes, cancer, and other conditions, but the clinical evidence is lacking. Read on to learn its potential benefits, dosage, and sources.

What is Cyanidin 3-Glucoside?

Also known as chrysanthemin – not to be confused with the chrysanthemum flower – cyanidin 3-glucoside is a member of the anthocyanin family of pigments. Anthocyanins are odorless and can appear blue, red, or black, depending on the acidity of the plant tissues. These are the same pigments that cause leaves to change color in the fall [1].

Cyanidin 3-glucoside occurs naturally in blueberries, acai, and black soybean among many other plants. Animal and cell studies suggest strong antioxidant and potential anti-diabetic and heart-protecting properties, but there’s no clinical evidence to back them up.

Snapshot

Proponents:

  • Lowers oxidative stress
  • May help with diabetes
  • May protect the liver and heart
  • May combat H. Pylori

Skeptics:

  • No clinical trials available
  • Unknown long-term safety
  • May have poor absorption
  • May interact with certain drugs

How It Works

The mechanism of action of cyanidin 3-glucoside is still an active area of research. Preliminary experiments show that the molecule acts as a powerful antioxidant. Cyanidin 3-glucoside may protect the heart and blood vessels by reducing oxidative stress [2, 3, 4, 5].

Anthocyanin extracts increase the activity of proteins in fat tissues that are involved in burning fat. One of these proteins (UCP-2) is currently being researched as a potential genetic marker and treatment target for type-II diabetes [6, 7].

People who are Th2 dominant experience hyperactive immune symptoms in the form of excessive allergic reactions. Cyanidin 3-glucoside may decrease Th2 response by suppressing its related immune signals (IL-4 transcription) [8].

Activation

The most common anthocyanin in many plants, such as black raspberries, is cyanidin 3-rutinoside. It needs to be activated by specific enzymes to cyanidin 3-glucoside in order to be used in the body [9].

Digestion

Cyanidin 3-glucoside enters the bloodstream from the gut, but it’s uncertain to what extent. Some studies suggest that less than 1% can be used by the body. It might, in fact, be broken down into other active compounds, which are yet to be discovered [10, 11].

C3g digestion was enhanced in one study in the presence of humangut bacteria in rats, compared to rats without gut bacteria. This suggests that our natural intestinal environment provides an advantage for digesting c3g [12].

Animal and Cellular Research (Lacking Evidence)

No clinical evidence supports the use of cyanidin 3-glucoside for any of the conditions listed in this section. Below is a summary of the existing animal and cell-based studies; they should guide further investigational efforts but should not be interpreted as supportive of any health benefit.

1) Diabetes

In animal studies, scientists observed the following effects of cyanidin 3-glucoside:

  • Reduced fat tissue and cells in diabetic mice with high blood fat levels. C3g increased fat cell differentiation, which is otherwise deficient in diabetes [13].
  • Decreased fasting blood glucose in diabetic mice. It also reduced diabetic complications in mice, such as damage to the kidneys, liver, and pancreas [14].
  • Decreased insulin resistance, increased insulin secretion, and decreased blood glucose levels after meals in treated groups, according to an analysis of rodent studies [15].

These results point to c3g as a promising option for improving blood sugar control, but the clinical evidence is lacking.

2) Heart Disease

According to preclinical research, C3g can lower cholesterol and thus potentially improve heart health [16].

Berry extracts containing cyanidin 3-glucoside reduced cholesterol levels in rats fed a high-cholesterol diet and also increased HDL cholesterol, which may be beneficial [17].

A study on diabetic rats showed less heart damage in the group treated with cyanidin 3-glucoside compared to controls [18].

C3g blocked the clogging process when applied to human blood platelets from healthy men and women [16].

People with metabolic syndrome usually have belly fat, and higher glucose levels and blood pressure, putting them at high risk for numerous diseases. A study on rats showed that c3g reversed symptoms of metabolic syndrome [19, 20].

4) Liver Protection

Dietary cyanidin 3-glucoside reversed signs of liver damage in mice with liver injury over eight weeks by reducing inflammation and cell death [21].

5) H. Pylori Infection

Helicobacter Pylori is a bacteria that can lead to a host of digestive problems, including ulcers and stomach cancer. One study found that cyanidin 3-glucoside reduced cell death in human stomach cells affected by H. Pylori by blocking the release of toxins [22, 23].

Limitations and Caveats

There is an absence of clinical trials on cyanidin 3-glucoside. Findings from animal and cell studies may not translate into the same health benefits in humans.

Additionally, it’s impossible to establish a safe and effective dosage because of the lack of clinical data [24].

Cyanidin 3-Glucoside Side Effects & Precautions

Keep in mind that the safety profile of cyanidin 3-glucoside is relatively unknown, given the lack of well-designed clinical studies. The list of side effects below is not a definite one, and you should consult your doctor about other potential side effects, your health condition and possible drug or supplement interactions.

Anthocyanins are present in many commonly consumed fruits. They are safe and no health risks are known from the amounts present in food. Extracts with cyanidin 3-glucoside were well tolerated in a study of 12 human subjects [25].

Drug Interactions

Supplement-drug interactions can be dangerous and, in rare cases, even life-threatening. Always consult your doctor before supplementing and let them know about all drugs and supplements you are using or considering.

C3g and other anthocyanins may interfere with chemotherapy drugs by either increasing or decreasing their activity [26].

Low doses of statins and c3g might potentially be combined for enhanced treatment of atherosclerosis [27].

When combined with immune cancer therapy, trastuzumab, c3g enhanced antitumor activity in animals and cells [28].

Cyanidin 3-Glucoside Supplementation

C3g supplements have not been approved by the FDA for medical use. In general, regulatory bodies aren’t assuring the quality, safety, and efficacy of supplements. Speak with your doctor before supplementing.

Although cyanidin 3-glucoside occurs naturally in many berries, it is also available as a supplement in the form of capsules and soft gels. Black bean extract is a common source for many commercially available supplements.

Dosage

Because C3g is not approved by the FDA for any condition, there is no official dose. Users and supplement manufacturers have established unofficial doses trial and error. Discuss with your doctor if C3g may be useful as a complementary approach in your case and which dose you should take.

Animal studies administered high daily doses of cyanidin 3-glucoside, which would be equivalent to 700-2000 mg daily for a person weighing about 150 lbs. In commercially available products, C3g doses range from 30-600 mg. None of these have been confirmed in human studies [18, 21].

It’s unly to receive such high doses of cyanidin 3-glucoside from natural sources acai or raspberries, although other health benefits of including fruits and berries into your diet are worth considering.

User Experiences

The opinions expressed in this section are solely from the users who may or may not have a medical background. SelfDecode does not endorse any specific product, service, or treatment. Do not consider user experiences as medical advice. Never delay or disregard seeking professional medical advice because of something you have read on SelfDecode.

Reviews for the product are mixed without reports of negative side effects. Many supplement users seek out Cyanidin 3-glucoside to increase muscle mass, endurance and boost weight loss. Some users express positive results, while others are not convinced that c3g made any observable difference.

Source: https://selfhacked.com/blog/cyanidin-3-glucoside/

CyaniMax™ Cyanidin 3 Glucoside

Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage

Origin:
Blackberry, Black Soybean Hall

Standards:
30%,40% Cyanidin-3-O-glucoside powder(HPLC)

Health Benefits:
Anti-Fatigue, Eye, Brain, Liver Health, Weight Management

CyaniMax™ FROM BGG IS REVOLUTIONARY

CyaniMaxTM from Global Natural Products Pioneer BGG breaks new ground in Antioxidant Protection with the highest-purity concentrations of the most powerful anthocyanin: BGG’s Cyanidin-3-O-Glucoside (C3G).

Firstly, black soybeans(Glycine max (L.) Merr), grown and harvested in Northeastern China. With rich soils and a perfect climate for farming black soybeans, BGG’s buyers source with rigid inspection and monitoring procedures to ensure that this extract is the finest.

Secondly and similarly, BGG’s sourcing of Blackberries, another ingredient and natural source possessing high concentrations of C3GBGG’s inspectors ensure the fruit reaches correct ripeness, and that all international standards for handling are observed, no detail is overlooked.

Two origins and specially process technique under stringent laboratory monitoring and control standards, CyaniMaxTM is achieved:

BGG’s CyaniMax™ is constantly tested in production to ensure that it contains the most potent concentration and purity of Cyanidin-3-O-Glucoside (C3G) and contains up to 80% in Anthocyanins.

The oxygen radical absorbance capacity (ORAC) method has validated BGG’s Cyanidin-3-O-Glucoside (C3G) as the STRONGEST antioxidant of the 14 main Anthocyanins.

Published test results have proven that BGG’s proprietary formula is three-times stronger than the standard; Trolox.

Existing research, and our own extensive testing, has led to breakthrough results with this benchmark-setting product:

NUMEROUS HEALTH BENEFITS

CyaniMax™ C3G has been linked to numerous health benefits due to its high antioxidant content: include improved vision, reduction to memory loss, enhanced motor skills, the promotion of controlled weight, improved blood circulation, cardiovascular protection, even as a tool for controlling diabetes…And there’s more: C3G may also prevent certain cancers and aid chemotherapy, according to recent research published in the Journal of Biological Chemistry.

PUBLISHED RESEARCH STUDIES

An animal study examined the dose dependent effects of blackberries containing C3G in ovariectomized rats: 38 rats were administrated and divided into four groups; the final body weight of rats treated with C3G was lower than the control group; and a C3G diet found a decreased expression level of hepatic nuclear factor kappa B (NF-?B) and cyclooxygenase-2 (COX-2).

These results showed in the rat study that C3G is protective against weight gain and inflammation associated with ovariectomy-induced menopause.

Much research has been done in this field: some has shown that C3G can improve atherosclerosis by inhibiting proliferation of TNF-?-induced vascular smooth muscle cells. Another paper reported that C3G from black soybean can ameliorate type II diabetes due to down-regulating the retinol binding protein IV expression in diabetic mice.

Other research into the anti-tumor spectrum of C3G reveals that its inclusion in a dietary regime can delay the development of malignancies, inhibit tumors, also promoter-induced carcinogenesis, and tumors metastasis in vivo, and provide protection for normal cells against attack by possessing similarities to chemo-preventive treatments.

DOSAGE

Highly stable: 36 month shelf life.

Dosage: 50-200 mg/day for adults.

Source: https://bggworld.com/cyanimax-cyanidin-3-glucoside/

Finally, A Different Take on Fat Loss

Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage
THE ULTIMATE FAT LOSS – MUSCLE BUILDING SUPPLEMENT HAS ARRIVED: LIPO-DREX WITH C3G (CYANIDIN 3-GLUCOSIDE) C3G forces nutrients into muscle instead of storing them as fat by triggering “nutrient partitioning”, a new ingredient technology found in iSatori’s LIPO-DREX™ Founder, CEO iSatori & Inventor of Bio-Gro

Nothing turns more heads then a tapered waist and razor sharp abs. It’s what every guy, and girl, wants.

Just think back to that guy who’s taken off his shirt on the beach or at the pool, to reveal six-pack abs and hard muscular body, and as you seethe with envy you watch ever other guy and girl stop and stare in awe.

It’s a unbelievable feeling that being ripped and muscular can bring you. And up until recently, we thought that simultaneously burning body fat and building muscle mass couldn’t happen.

We’ve always been duped into thinking that you have ‘bulk’ then ‘cut.’

Well, I’m excited to tell you that new research suggests that this is possible an ingredient called Cyanidin-3-Glucoside, or “C3G” for short. C3G is the major ingredient matrix found in our all new Lipo-Drex by iSatori.

In this article I’d to explain What C3G is; How it works; What the science says about it; and Other ingredients and their benefits in Lipo-Drex…and How to use it to transform your body into the ripped physique you’ve been working for.

What is C3G?

Cyanidin-3-Glucoside or C3G as i’ll refer to it from now on – is an ingredient known for its positive effects on body fat loss, while also gaining lean muscle. This is due to a scientific concept called “nutrient partitioning.” (We’ll get back to this concept of ‘nutrient partitioning’ later on and why it’s so important to us).

The orgins of C3G is a special purple colored pigment from the anthocyanidin group. I know, lots of science, bare with me.

C3G is found primarily in the skins and colored regions of dark purple fruits, grains corn, and berries such as blackberries, and aronia berries.

Although C3G is bound to glucose (hence the “glucoside” part), its calorie content is negligible, even in the highest doses (thereby producing absolutely no calories in C3G).

How does C3G work?

In simple terms, C3G works as a “nutrient partitioning” agent. In other words, C3G helps to divert nutrients consumed (mainly fats and carbohydrates) away from fat cells and drives them into muscle cells. Now, if this doesn’t sound a fitness fanatic’s dream, then you must be living on another planet.

C3G does this by activating the master cell regulator, called AMPK (adenosine-monophosphate-protein-activated-kinase), which in turns signals an enzyme called Lipoprotein lipase (or LPL) to deactivate in the fat cells and activate within the muscle cells (See fig. 1).

Simply put, C3G drives the nutrients you get from food away from the fat cell and redirects them INTO the muscle cell, so that you can lose weight and build muscle AT THE SAME TIME.

What does the science say about C3G?

C3G was first investigated for its potential to help with the management of insulin.

Later, it was investigated for weight loss effects in prevention of obesity, and surprisingly was discovered in a more recent study that it could increase muscle mass.

Further science on C3G the concluded that it may be able to reduce body fat and actually increase lean muscle mass, DURING periods of controlled overfeeding ( a “dirty bulk”, if you will).

In the most conclusive study (Tsuda, T et al.), animals were fed a high fat, high sugar diet, one group was given C3G, and the other group did not receive the C3G. The differences in results between the two groups were very impressive with regard to change in bodyweight (bodyfat and muscle mass).

One researcher was quoted stating, “fat cells where shrinking and muscle cells were growing”, to put the results simply.

Additional research from Tsuda, showed that subjects taking the C3G benefited from reduced fat cell lining inflammation and an increase in secreted adiponectin levels, which helps regulate blood sugar (glucose) dispel and break down fatty acids to lose weight faster.

Further research (Luo, X; and Oak, MH, et al.) has revealed that C3G can exert a pro-inflammatory effect and prevent subsequent damage, allowing for the muscle to repair and recovery sooner after exercise. What was most interesting, however, is in the Tsuda study, the more calories that were consumed in the test subjects the more muscle mass that was gained. 

Nutrient Partitioning – The Ultimate Body Transformation Agent

I’m fairly certain this won’t be the last time you hear about “nutrient partitioning” — a novel scientific concept that produces two diametrically opposing biological goals – simultaneous bodyfat loses and muscle gains.

And rarely do I find myself compelled by such impressive data, that I’ve discovered from C3G, that I would make such a bold statement – calling it “The Ultimate Body Transformation Agent.” But in this case, I firmly believe the data speaks for itself.

It’s for these reasons we’ve worked tirelessly ( we originally did with our BIo-Gro bio-active peptides) and created a ‘Super C3G’ ingredient, combining three forms of cyandin-3-glucoside, to produce the most profound effect in ‘nutrient partitioning.

” It’s called C3G-Max™; made from Aronia, Purple Corn and Blackberries, standardized for potency and purity of highest grade cyandin-3-glucoside.

C3G-Max can only be found in LIPO-DREX™, our newest innovation in fat-loss/muscle-building suppplements from iSatori designed to impart the strongest ‘nutrient partitioning’ available and help users, along with exercise, lose bodyfat and increase muscle mass, at the same time – to achieve the coveted lean and muscular physique.  

So What About the Other Ingredients in Lipo-Drex…

When we formulated LIPO-DREX, even though it was certainly impressive alone with its nutrient partitioning, I didn’t want to just stop at C3G, so we were sure to include other potent ingredients to make LIPO-DREX the strongest thermogenic fat burner on the market;

  • Coleus Forskohlli Extract, which aids in the loss of fat but also the maintenance of lean muscle.
  • N-Acetyl L-Carnitine, to aid in the release and metabolism of fatty acids supporting energy and fat loss.
  • Green Tea Extract to increase resting metabolic rate to burn more calories, driving overall weight loss.
  • Berberine HCL, which supports nutrient partitioning by stimulating AMPK.
  • Caffeine Anyhydrous to increases energy and focus via the central nervous system. Assists in caloric expenditure and triggers thermogenesis.
  • TeaCrine™ Theacrine, to help prevent the energy crash so familiar to caffeine, TeaCrine keeps the energy coming by adding an extended release ingredient.
  • L-Ornithine which is shown in specific doses to extend the half-life of caffeine, in turn extending the energy and fat mobilization effects.
  • Yohimbine HCL which works to increase adrenaline levels in the body and to mobilize fat.
  • CapsiTherm(r) Cayenne Pepper contains the active capsaicin, capsaicinoid, and capsinoid These molecules have been shown to increase thermogenesis and energy expenditure (causing you feel a warmer body temperature).
  • Bacopa, a nootropic ingredient that helps with cognition, memory and focus.
  • Hordenine, for increased metabolic rate and energy, as well as a decrease in appetite reportedly due to slowed digestion.

We spared no expense. Didn’t cut corners. We packed 659.5 precise milligrams of powerful thermogenic fat-burning / muscle-building ingredients inside every capsule of Lipo-Drex. It’s what you’ve come to expect from iSatori, and I wasn’t go do anything less with this new creation.

How Do I Use it?

When i’m asked on a scale of one to ten, what the level of energy, I enthusiastically reply, “11”! That’s a full dose of two (2) capsules. You take them in the morning, upon waking or 30 minutes before your largest meal of the day.

“It feels just you are on your favorite study aid and can work for hours,” was one comment I received from a local college student here in Colorado.

So my recommendation is to assess your tolerance with one capsule, if you’re under 150 pounds of bodyweight or very sensitive to caffeine, and take two capsules if you’re over 150 pounds of bodyweight.

But whatever you do, please don’t stack LIPO-DREX with other stimulant containing products.

I’m sure by now you get the point. LIPO-DREX is in a class of its own. The one an only nutrient partitioning thermogenic fat loss pill designed to aid in fat loss, muscle hardening, and extreme energy.

So, if you want all the “perks” that come with chiseled, granite- abs, and possess a harder, more muscular looking body than all the other guys and girls around, there’s only one obvious choice: LIPO-DREX.

Give it a try, and follow a sound nutrition plan (If you need one, try my “carb-Cycling Diet), train harder than ever, and I promise you won’t be disappointed.

(Then come tell me how well it worked for you! You can find me on Instagram or @stephenadele or on @isatoritech).

Scientific References on Cyanidin-3-Glucoside (C3G) inside LIPO-DREX:

Grace MH, et al Hypoglycemic activity of a novel anthocyanin-rich formulation from lowbush blueberry, Vaccinium angustifolium Aiton . Phytomedicine. (2009)

Luo X, et al Cyanidin-3-glucoside suppresses TNF-α-induced cell proliferation through the repression of Nox activator 1 in mouse vascular smooth muscle cells: involvement of the STAT3 signaling . Mol Cell Biochem. (2012).

Oak MH, et al Delphinidin and cyanidin inhibit PDGF(AB)-induced VEGF release in vascular smooth muscle cells by preventing activation of p38 MAPK and JNK .Br J Pharmacol. (2006).

Scazzocchio B, et al Cyanidin-3-O-β-glucoside and protocatechuic acid exert insulin- effects by upregulating PPARγ activity in human omental adipocytes .Diabetes. (2011)

Sasaki R, et al Cyanidin 3-glucoside ameliorates hyperglycemia and insulin sensitivity due to downregulation of retinol binding protein 4 expression in diabetic mice. Biochem Pharmacol. (2007)

Tsuda, T et al., “Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice” Journal of Nutrition (2003) July, 133(7):2125-30.

Tsuda T, et al Anthocyanin enhances adipocytokine secretion and adipocyte-specific gene expression in isolated rat adipocytes . Biochem Biophys Res Commun. (2004)

Wei X, et al Cyanidin-3-O-β-glucoside improves obesity and triglyceride metabolism in KK-Ay mice by regulating lipoprotein lipase activity . J Sci Food Agric. (2011).

Stephen Adele 

Source: https://campusprotein.com/blogs/articles/85533892-finally-a-different-take-on-fat-loss

Cyanidin-3-Glucoside-Rich Extract from Chinese Bayberry Fruit Protects Pancreatic β Cells and Ameliorates Hyperglycemia in Streptozotocin-Induced Diabetic Mice

Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage

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Black Rice Extract Cyanidin-3-glucosides (C3G)

Potential Benefits of Cyanidin 3-Glucoside (C3G) + Dosage

Product NameBlack Rice Extract Cyanidin-3-glucosides (C3G)
Latin NameOryza sativa
Other namespurple rice extract, Cyanidin-3-glucoside,C3G, ProC3G, Chrysanthemin, forbidden rice, Cy-3-glc
Active ingredientCyanidin-3-glucosides, Anthocyanin
CAS Number7084-24-4
Molecular formulaC21H21O11+, Cl-C21H21ClO11
Molecular weight484.83, 449.38
Specifications5%-25% Anthocyanins 20%-50% Cyanidin-3-glucosides
Part Usedfull part seed
Appearance/colorviolet or black fine powder

What is black rice extract?
Black Rice Extract, according to Wikipedia, has many other names, such as purple rice extract, Chrysanthemin, C3G, Cyanidin-3-glucoside,etc, Oryza sativa,etc. Black Rice has long been consumed in China and is considered to be a healthy superfood because of its antioxidant content that able to prevent oxidative stress. In the long history of China, it has been used as an ancient and precious food similiar to normal white rice. Legend has it that this Chinese black rice got its name because it was so nutritionally beneficial that only the emperors were allowed to eat it. However, nowadays, we can get it all year for production since it is non-seasonal.

Black Rice Extract is an ancient and precious food similar to normal white rice. It has the function of removing free radicals, lowers activity of oxidizing enzymes and can absorb cholesterol. This food is used as in food supplements, functional beverages and food coloring.

The constituents of black rice extract
Black rice or purple rice contains anthocyanin glycosides such as chrysanthemin (Cyanidin-3-glucoside) that are not contained in other types of rice.

Anthocyanin such as Cyanidin-3-Glucoside, Cyanidin-3-Rhamnoglucoside, Malvidin-3-Galactoside, and Peonidin-3-Glucoside,etc. However, Cyanidin-3-glucosides,or commonly known as C3G, is the most popular ingredient known.

Therefore let’s make a brief introduction to Cyanidin-3-glucosides (C3G).

What is Cyanidin-3-glucosides (C3G)?Have you heard of Cyanidin-3-glucosides (C3G) before? Dr Oz mentioned C3G and pterostilbene on his Dr Oz’s Show in 2013. It is relatively new to most supplement folks.Cyanidin-3-glucosides (C3G) belongs to the same class of phytonutrients as other popular antioxidants found in fruits, vegetables, herbs and grains.

Known as anthocyanins, these water-soluble nutrients are analogs of the plant pigments responsible for blue, red, orange and purple coloring. Many anthocyanins have been isolated, researched and found to be beneficial for human health. C3G is one of the most predominant anthocyanins found in nature.

It’s also one of the most bioactive nutrients in its class and one of the most clinically researched.

In the discussion of high-powered antioxidants, there have historically been two main contenders: vitamin C and resveratrol. Careful and extensive research has demonstrated that these two nutrients deliver antioxidant protection against free radicals, thus helping us live longer, healthier lives.

Now comes C3G (Cyanidin-3-glucoside), the next generation in cutting-edge, anti-aging nutraceuticals. Anthocyanins (particularly C3G) have been found to nourish the body by supporting a variety of fundamental mechanisms.

C3G may defend against free radicals generated by oxidative stress and has been shown to support healthy cellular aging through its powerful antioxidant activity.

Source: http://herbnutritionals.com/herbal-extracts/black-rice-extract-cyanidin-3-glucosides-c3g/

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