- Agmatine – Better than Arganine?
- Agmatine Sulfate: Benefits, Dosage & Side Effects
- Muscle Growth
- Pain Relief
- Depression and Anxiety
- Blood Glucose Regulation
- Food Sources of Agmatine Sulfate
- Agmatine Sulfate Dosage and Side Effects
- Side Effects
- The Bottom Line
- Agmatine compedium – benefits, dosages and side-effects
- What is agmatine?
- Properties of agmatine
- Agmatine – side effects
- Agmatine – reviews
- Why has agmatine been withdrawn?
- Agmatine benefits and side effects
- Agmatine benefits
- Agmatine side effects
Agmatine – Better than Arganine?
Posted on February 02, 2015
Researchers have known about agmatine since 1910, but it has taken over 100 years to appreciate how much this simple molecule can do. Scientists have only recently discovered that agmatine may improve cognition and memory, protect nerve cells from death and destruction, reduce anxiety, and improve depression.1
What is Agmatine?
Agmatine is a small molecule that the body makes naturally from the amino acid, arginine. While the total concentration of agmatine in the body is low, it shows up in concentrated pockets throughout the body.
In fact, agmatine has effects on many different organs such as the kidneys, heart and blood vessels, and the brain. wise, agmatine has many roles in health and disease, such as Alzheimer’s disease, drug addiction, diabetes, anxiety disorder, depression, and even cancer.
1 Some diseases may be linked to deficiencies in agmatine levels and activity, while performance may be enhanced by agmatine supplementation.
Agmatine Effects on the Kidney
Kidney function can decrease as part of certain disease processes. Diabetes and high blood pressure are known to wreak havoc on the kidneys, for example. Moreover, kidney function declines simply as a person grows older. If left untreated, kidney disease can lead to kidney failure and may require dialysis or kidney transplant.
Recent research has revealed that agmatine has a number of beneficial effects on the kidney. Agmatine protects the kidney from injury that is caused by blood vessel disease2 and by inflammatory diseases.3 Agmatine also improves kidney function.
4,5 Specifically, agmatine increases the rate at which the kidney filters the blood.5 The filtration rate of the kidney (GFR) is one of the main indicators of kidney health and function.
In fact, measuring GFR is the main way that doctors determine the health of your kidney.
A Role for Agmatine Sulfate in Type 2 Diabetes
In type 2 diabetes, cells in the body become less sensitive to the effects of insulin.
Some treatments for type 2 diabetes, Avandia (rosiglitazone) and Actos (pioglitazone), work by increasing how cells respond to insulin.
Other drugs, glyburide and glipizide, stimulate the pancreas to secrete more insulin. Indeed, people with more advanced diabetes may need injections of insulin to treat the disease.
Amazingly, agmatine has been shown to have all three anti-diabetic effects. It sensitizes cells to the effects of insulin, in at least two different ways.6 Agmatine acts on the pancreas, causing it to release insulin.7,8 Agmatine even acts insulin itself on cells.9 Taken together, this strongly suggests that agmatine sulfate may be a useful addition in the treatment of type 2 diabetes.
Agmatine Sulfate’s Actions on the Heart and Blood Vessels
Historically, agmatine generated the most interest among researchers for its ability to beneficially affect the cardiovascular system by reducing the heart rate and blood pressure.
10 It is important to note, however, that this blood pressure lowering effect is considered mild compared to today's blood pressure medications. In other words, agmatine only modestly decreases blood pressure and heart rate compared to prescription drugs lisinopril and metoprolol.
Nevertheless, agmatine is a natural molecule that the body produces (see Safety of Agmatine below) while prescription medications carry the risk of certain side effects.
Also, because of agmatine’s effects on the kidney, the supplement may be helpful in people with congestive heart failure. Specifically, agmatine increases urinary flow and filtration.
Agmatine sulfate also enhances a phenomenon called natriuresis, which is the body's way of getting rid of excess sodium.11 People with congestive heart failure must reduce their intake of fluid and salt to prevent exacerbations of their disease.
Therefore, agmatine may be a useful addition to the treatment of congestive heart failure.
Safety of Agmatine
Agmatine is a natural substance produced by various areas of the body. Thus, within normal circulating levels, there is no inherent danger of agmatine. Indeed, several disease states seem to be associated with abnormally low levels of agmatine in various locations in the body.1
Researchers have shown that adult rats can consume large amounts of agmatine sulfate over three months without negative effects in behavior or in their organs.30 The only noticeable effects were slight but significant reductions in body weight and blood pressure.
While clinical trials in humans have shown that taking 3.5 g of agmatine sulfate each day is safe over 21 days31, two researchers consumed 2.6 g of agmatine sulfate each day for five years and had no adverse events.
32 Thus, agmatine sulfate is ly to be safe when taken in 2 to 3 g doses each day for up to five years or longer in healthy individuals.
Laboratory and clinical studies show that agmatine is a natural substance that exerts a wide array of impressive health benefits. The supplement has a number of interesting effects on the heart, and kidneys. Agmatine sulfate lowers blood pressure and heart rate while helping the kidney to get rid of excess salt and fluid.
This may be particularly useful in people with congestive heart failure. The supplement improves kidney function by increasing the filtration rate and protects the kidney from blood vessel disease and inflammation. In addition to protective effects on the kidney, agmatine sulfate improves insulin sensitivity, increases insulin secretion, and can act insulin itself.
These findings strongly suggest that the agmatine may be helpful in people with type 2 diabetes.
Finally, agmatine sulfate may represent a new type of painkiller (analgesic) that controls pain without directly affecting the opioid receptor. This means it can block pain without addiction and may even help those who have become addicted to opioids morphine and Vicodin.
The potential benefits of agmatine sulfate to support numerous complex systems simultaneously, combined with its low risk profile, make this compound an attractive addition to any supplementation program.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
1. Piletz JE, Aricioglu F, Cheng JT, et al. Agmatine: clinical applications after 100 years in translation. Drug Discov Today. Sep 2013;18(17-18):880-893. doi:10.1016/j.drudis.2013.05.017
2. Sugiura T, Kobuchi S, Tsutsui H, et al. Preventive mechanisms of agmatine against ischemic acute kidney injury in rats. Eur J Pharmacol. Jan 28 2009;603(1-3):108-113. doi:10.1016/j.ejphar.2008.11.062
3. Ishizuka S, Cunard R, Poucell-Hatton S, et al. Agmatine inhibits cell proliferation and improves renal function in anti-thy-1 glomerulonephritis. J Am Soc Nephrol. Dec 2000;11(12):2256-2264.
4. Penner SB, Smyth DD. Natriuresis following central and peripheral administration of agmatine in the rat. Pharmacology. Sep 1996;53(3):160-169.
5. Lortie MJ, Novotny WF, Peterson OW, et al. Agmatine, a bioactive metabolite of arginine. Production, degradation, and functional effects in the kidney of the rat. J Clin Invest. Jan 15 1996;97(2):413-420. doi:10.1172/jci118430
6. Su CH, Liu IM, Chung HH, Cheng JT. Activation of I2-imidazoline receptors by agmatine improved insulin sensitivity through two mechanisms in type-2 diabetic rats. Neurosci Lett. Jul 3 2009;457(3):125-128. doi:10.1016/j.neulet.2009.03.093
7. Shepherd RM, Hashmi MN, Kane C, Squires PE, Dunne MJ. Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus-response coupling of insulin release. British Journal of Pharmacology. 1996;119(5):911-916. doi:10.1111/j.1476-5381.1996.tb15759.x
8. Sener A, Lebrun P, Blachier F, Malaisse WJ. Stimulus-secretion coupling of arginine-induced insulin release. Insulinotropic action of agmatine. Biochem Pharmacol. Jan 15 1989;38(2):327-330.
9. Pfeiffer B, Sarrazin W, Weitzel G. [Insulin- effects of agmatine derivatives in vitro and in vivo (author's transl)]. Hoppe Seylers Z Physiol Chem. Oct 1981;362(10):1331-1337.
10. Raasch W, Schafer U, Chun J, Dominiak P. Biological significance of agmatine, an endogenous ligand at imidazoline binding sites. Br J Pharmacol. Jul 2001;133(6):755-780. doi:10.1038/sj.bjp.0704153
11. Smyth DD, Penner SB. Peripheral and central imidazoline receptor-mediated natriuresis in the rat. Ann N Y Acad Sci. Jun 21 1999;881:344-357.
12. Uzbay T. A new target for diagnosis and treatment of CNS disorders: agmatinergic system. Curr Med Chem. 2012;19(30):5116-5121.
13. Uzbay TI. The pharmacological importance of agmatine in the brain. Neurosci Biobehav Rev. Jan 2012;36(1):502-519. doi:10.1016/j.neubiorev.2011.08.006
14. Bence AK, Worthen DR, Stables JP, Crooks PA. An in vivo evaluation of the antiseizure activity and acute neurotoxicity of agmatine. Pharmacol Biochem Behav. Feb 2003;74(3):771-775.
15. Luszczki JJ, Czernecki R, Dudra-Jastrzebska M, Borowicz KK, Czuczwar SJ. Influence of agmatine on the protective action of numerous antiepileptic drugs against pentetrazole-induced seizures in mice. Pharmacol Rep. Mar-Apr 2009;61(2):252-260.
16. Luszczki JJ, Czernecki R, Wojtal K, Borowicz KK, Czuczwar SJ. Agmatine enhances the anticonvulsant action of phenobarbital and valproate in the mouse maximal electroshock seizure model. J Neural Transm. Nov 2008;115(11):1485-1494. doi:10.1007/s00702-008-0046-3
17. Bradley KJ, Headley PM. Effect of agmatine on spinal nociceptive reflexes: lack of interaction with alpha2-adrenoceptor or mu-opioid receptor mechanisms. Eur J Pharmacol. Jul 23 1997;331(2-3):133-138.
18. Regunathan S. Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence. AAPS J. 2006;8(3):E479-484. doi:10.1208/aapsj080356
19. Rushaidhi M, Collie ND, Zhang H, Liu P. Agmatine selectively improves behavioural function in aged male Sprague-Dawley rats. Neuroscience. Aug 30 2012;218:206-215. doi:10.1016/j.neuroscience.2012.05.015
20. Bhutada P, Mundhada Y, Humane V, et al. Agmatine, an endogenous ligand of imidazoline receptor protects against memory impairment and biochemical alterations in streptozotocin-induced diabetic rats. Prog Neuropsychopharmacol Biol Psychiatry. Apr 27 2012;37(1):96-105. doi:10.1016/j.pnpbp.2012.01.009
21. Bergin DH, Liu P. Agmatine protects against beta-amyloid25-35-induced memory impairments in the rat. Neuroscience. Aug 25 2010;169(2):794-811. doi:10.1016/j.neuroscience.2010.05.004
22. Liu P, Rushaidhi M, Collie ND, Leong MT, Zhang H. Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats. Behav Neurosci. Jun 2008;122(3):557-569. doi:10.1037/0735-7044.122.3.557
23. Moretti M, Matheus FC, de Oliveira PA, et al. Role of agmatine in neurodegenerative diseases and epilepsy. Front Biosci (Elite Ed). 2014;6:341-359.
24. Matheus FC, Aguiar AS, Jr., Castro AA, et al. Neuroprotective effects of agmatine in mice infused with a single intranasal administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Behav Brain Res. Dec 1 2012;235(2):263-272. doi:10.1016/j.bbr.2012.08.017
25. Seidl R, Beninati S, Cairns N, et al. Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease. Neurosci Lett. Mar 15 1996;206(2-3):193-195.
26. Bernstein HG, Muller M. Increased immunostaining for L-ornithine decarboxylase occurs in neocortical neurons of Alzheimer's disease patients. Neurosci Lett. Feb 17 1995;186(2-3):123-126.
27. Kuo JR, Lo CJ, Chio CC, Chang CP, Lin MT. Resuscitation from experimental traumatic brain injury by agmatine therapy. Resuscitation. Dec 2007;75(3):506-514. doi:10.1016/j.resuscitation.2007.05.011
28. Kim JH, Lee YW, Park YM, et al. Agmatine-reduced collagen scar area accompanied with surface righting reflex recovery after complete transection spinal cord injury. Spine (Phila Pa 1976). Dec 1 2011;36(25):2130-2138. doi:10.1097/BRS.0b013e318205e3f7
29. Park YM, Lee WT, Bokara KK, et al. The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells. PLoS One. 2013;8(1):e53911. doi:10.1371/journal.pone.0053911
Agmatine Sulfate: Benefits, Dosage & Side Effects
At some point, every fitness and bodybuilding junkie has been bombarded with outlandish claims of workout supplements promising overnight gains, super strength, and an instant ripped physique. These “magic pills” all claim to give you amazing results, but most of the time, they’re false at best and downright dangerous at their worst.
This might leave you wondering if there are really any pre-workout supplements that actually work – without an endless list of unwanted side effects.
Enter agmatine sulfate – a bodybuilding supplement backed by extensive scientific research. (x)
Agmatine sulfate is a naturally-occurring derivative of the amino acid arginine. It carries out many important functions in the body, including acting as a neuromodulator and neurotransmitter within the central nervous system. It also plays an important role in nitric oxide synthesis, which promotes healthy circulation and muscle pump.
Agmatine sulfate is popularly taken as a bodybuilding supplement, but it does much more than give you a serious muscle pump.
Of all the known benefits of agmatine sulfate, its ability to build muscle is the most popular. When used in conjunction with weight lifting and resistance exercises, agmatine helps to fuel muscle growth through a few different mechanisms.
Agmatine sulfate stimulates the production of luteinizing hormone, which has a direct impact on increasing levels of testosterone. (x) Testosterone is an important hormone for building muscle mass because it increases muscle protein synthesis –which helps you get the massive gains you’ve always wanted. (x)
Agmatine also helps regulate the enzyme responsible for the production of nitric oxide. The nitric oxide pump action is important for improving vasodilation and delivering nutrients to muscle tissue. (x)
Some people report having an increased appetite when taking agmatine sulfate powder—another benefit for bodybuilders, as a bigger appetite means a bigger caloric load, which can help build lean, strong muscle faster.
Several studies suggest that agmatine sulfate may provide pain relief. One study in particular examined the long-term use of agmatine sulfate for pain relief and found that it caused no significant adverse side effects. (x) (x) (x)
If you’re a bodybuilder, athlete, at the gym often, or if you suffer from chronic pain, try adding agmatine sulfate supplements to your nutrition regime for relief from post-workout aches or chronic pain.
Depression and Anxiety
According to the Anxiety and Depression Association of America, anxiety affects nearly 20% of the adult population, and major depressive disorder is the leading cause of disability for people aged 15-44. (x)
There are various methods to treat depression and anxiety. These include various forms of psychotherapy and medications.
(x) While medication is often a necessary component of care, many people are discouraged by the side effects and look for more natural ways to relieve their symptoms.
Research is ongoing, but suggests that agmatine sulfate may help relieve symptoms of anxiety and depression.
In one preliminary study, agmatine sulfate was administered to participants who had been diagnosed with major depressive disorder. The duration of treatment was 4-6 weeks, during which time some of the participants showed improvement in their symptoms while not taking additional pharmaceuticals. (x)
Blood Glucose Regulation
In multiple studies, agmatine sulfate has been shown to regulate blood glucose, both in response to physical exercise and for diabetics lacking insulin. (x) (x) (x)
Agmatine sulfate regulates blood glucose by activating imidazoline receptors, which help lower blood glucose levels. As an additional benefit, this process also leads to an increase in endorphins, which can boost mood and help maximize your athletic performance for a leaner physique.
Food Sources of Agmatine Sulfate
Agmatine sulfate is a bacteria byproduct, meaning that it’s primarily found in fermented foods beer, breads, soybean paste, miso, wine, sauerkraut, kefir and ripened cheese. (x)
It can be difficult to get an adequate amount of agmatine sulfate through food alone, especially if you’re taking it for therapeutic or medicinal purposes, which is why agmatine sulfate supplements could be a beneficial addition to your nutrition routine.
Agmatine Sulfate Dosage and Side Effects
Because the supplement can be taken to address numerous health issues, there is currently no standard agmatine sulfate dosage.
The recommended range is 1.6 – 6.4 mg or agmatine sulfate per kilogram of body weight. It is not advised to exceed 6.4 mg/kg of body weight. (x)
Here’s how to calculate dosage pounds instead of kilograms:
- 1 kilogram is equivalent to 2.2 pounds.
- To calculate your weight in kilograms, first, take your weight in pounds and divide it by 2.2. For example, if a person weighs 120 pounds, the formula would look this: 120/2.2 = 54.5kg. There are also online tools that can be used to help you with this calculation. (x)
- Next, take your weight in kilograms and then multiply it by the number of agmatine milligrams to determine your agmatine dosage range.
- For example: 54.5kg x 1.6 mg = 87.2 mg and 54.5kg X 6.4 mg = 348.8 mg. (Feel free to round these numbers if you prefer.)
- The dosage range for a 120lb person would be between 87 mg and 349 mg of agmatine sulfate.
Here’s a table of dosage range in increasing 20lb increments:
- A 120lb person could take between 87 mg and 349 mg of agmatine sulfate each day
- A 140lb person could take between 102 mg and 407 mg of agmatine sulfate each day
- A 160lb person could take between 116 mg and 465 mg of agmatine sulfate each day
- A 180lb person could take between 131 mg and 523 mg of agmatine sulfate each day
- A 200lb person could take between 145 mg and 581 mg of agmatine sulfate each day
It’s important to accurately measure the dosage of agmatine sulfate powder to avoid exceeding the maximum recommended intake unless you first discuss it with your doctor.
Biologically, agmatine sulfate utilizes the same transport mechanisms as arginine, so absorption can be hindered when taken with protein. (x) For best results, do not take agmatine sulfate powder with other supplements and do not exceed the recommended dosage to compensate for hindered absorption if you do.
Reports of agmatine sulfate side effects are more anecdotal than research-based. Sources do cite known side effects of L-arginine, which is closely related to agmatine sulfate.
These include mild effects such as bloating, abdominal discomfort, diarrhea, low blood pressure and allergies, particularly those that affect the airways.
(x) Anecdotal reported side effects of agmatine sulfate include increased appetite, minor gastrointestinal discomfort and lowered blood pressure.
Agmatine sulfate can interfere with the absorption of some medications. wise, certain medication can affect the absorbtion of agmatine sulfate supplements. (x) Anyone with a known pre-existing medical condition should consult their doctor before taking agmatine sulfate to assess the risks of potential medication interactions.
The Bottom Line
Agmatine sulfate is a naturally-occurring amino acid derivative that has proven to be a beneficial agent in a number of health-related applications. If you’re looking to maximize your workout, build lean muscle, ease post-workout pain and boost your mood, agmatine sulfate is a beneficial supplement to add to your nutrition routine.
By: Angel Woodyard
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HPLC certified Agmatine Sulfate
What is Agmatine?
Agmatine is a byproduct of the amino acid arginine, but goes well beyond arginine in terms of benefits. Agmatine works through stimulating the release of pituitary hormones, including Luteinizing Hormone (LH) and Growth Hormone (GH).
Agmatine has a variety of benefits, and can be beneficial and desirable for athletes and bodybuilders as well as fitness enthusiasts and people in search of a healthier lifestyle as they age. Agmatine also increases Nitric Oxide (N.
O) through two pathways – by stimulating the release of Nitric Oxide, while also inhibiting types of Nitric Oxide Synthase (enzymes that break down N.O.)
What are the benefits of Agmatine?
Agmatine appears to be a very versatile supplement, we decided to carry it due to the overwhelming number of requests and the amount of information we found from postings all over the Internet.
Peole using this supplement are reporting improved endurance, improved recovery, enhanced performance, dramatic and long lasting pumps, and improved overall body composition including increased lean muscle and decreased body-fat.
Some people are reporting pumps that last all day with supplementation of 1-2 grams per day.
Specific Reported Benefits Include:
Increased Pumps – Although, we have contended that the creatine nitrates and amino acid nitrates help create the best pumps imaginable (and we still believe this to be the case) the effects of the nitrates tend to last up to 2-3 hours.
People taking Agmatine sulfate have reported the pumps to be better than any of the conventional NO boosters, Arginine AKG and Citrulline Malate and they also report the pumps lasting all dayImproved Insulin Response – Agmatine may help improve insulin response through enhanced insulin production, which can lead to positive benefits for those looking to improve body composition. Improved insulin response is thought of in bodybuilding circles as a key to a leaner, harder, more muscular body.Nootropic Effect – Agmatine may help those looking to achieve a mental edge, whether it is in the gym or in day to day life. It can also help support a healthy mood and has anti-anxiety and antidepressant properties.Stimulation of LH & GH Levels – In addition to the obvious appealing effect on overall body composition, the stimulation of GH and LH levels can also be beneficial for helping maintain a healthy lifestyle as we age. This stimulation of pituitary hormones may also lead to stimulation of other hormones such as IGF-1.Neuroprotective Role – Agmatine plays a neuroprotective role due to its role as an antioxidant and its prevention of over excitation by glutamate.
Cardiovascular Benefits – Agmatine has a potential hypotensive benefit that may help aid in cardiovascular health. This hypotensive role is important in a healthy lifestyle for obvious reasons, but may also be found to be beneficial for bodybuilders or athletes.
Summary of Benefits:
Increased Nitric Oxide SynthesesInhibit NO Synthase (the enzyme responsible for NO breakdown)Stimulation of L.H. (Luteinizing Hormone) & G.H. (Growth Hormone) LevelsPromote a Healthy & Positive Mood (Anti-Anxiety & Antidepressant Properties)Promote Nutrient Delivery to Muscle CellsSupports Overall Anabolic EnvironmentEnhanced Insulin ResponseNeuroprotective SupportCardiovascular Health
Potential Side Effects of Agmatine
Agmatine is derived from arginine, a primary amino acid. Agmatine acts as a neurotransmitter to induce production of growth hormone, nitric oxide, creatine and protein decrease blood glucose levels; and aid in the removal of nitrogen waste products from the body.
A report in the Proceedings of the National Academy of Sciences indicates that agmatine is capable of preventing and treating spinal cord injuries, inflammation and neuropathy; however, every exogenous supplement has some side effects associated with use or overuse.
The patent for agmatine-containing products indicates that only three of the trial participants reported gastrointestinal disruptions at low doses.
Those disruptions included diarrhea, nausea and vomiting that began after two days of taking agmatine and continued until treatment ceased.
Only one of the people experiencing these problems dropped the clinical trial because of the discomfort caused by agmatine.
Lower Pain Threshold
A study published in the “European Journal of Pharmacology” indicated that large doses of agmatine actually lowered the overall pain threshold even though low doses improved overall response to chronic pain.
Rats were utilized to determine if agmatine was capable of improving the response to acute pain from a new injury at low doses.
Unfortunately, agmatine appears to have little ability to limit acute pain, even though the same dose appeared to stop pain perception from old injuries.
Agmatine is a low-affinity N-methyl-D-aspartate, or NMDA, antagonist; thus, the threat of neurotoxicity is possible although extremely unly.
According to agmatine’s patent information, it has a 500,000-times lower affinity for NMDA receptors than typical antagonists.
A report in “Science” indicates that NMDA antagonists may produce hallucinations, and they have been shown to cause morphological changes in the cerebral cortex of rats
Read more: http://www.livestrong.com/article/275087-agmatine-side-effects/#ixzz1QbRl78AK
Suggested Dosage of Agmatine
For most people, the usual agmatine dosage consists of 500mg twice daily. Some prefer to take 500mg pre workout, and then another 500mg dose after they finish their routine. Others take the entire dose at one time. Agmatine is readily available in a powder form, and the price varies according to manufacturer.
However, it is very important to note that there has not been very much literature published on Agmatine sulfate and recommended dosages have not been established.
Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Pregnant women should not take this supplement. Always consult your doctor first.
Shelf Life: This product will retain a 2 year shelf life from the date of manufacturer if properly sealed and stored in a dry, cool environment outside of direct sunlight.
Why Muscle Feast, LLC?
We guarantee our supplements to be the freshest and purest available: Muscle Feast, LLC supplements are manufactured under the strictest HACCP, FDA, and Kosher standards, producing the highest quality and purest supplements available.
Our raw ingredients undergo state of the art analysis to ensure zero impurities and strict adherence to product labeling. Muscle Feast, LLC is registered with the FDA and is regulated and inspected regularly by the USDA under the direction of the State of Ohio Department of Agriculture.
When it comes to price and quality you can’t beat Muscle Feast. We guarantee it!
Important facts you should know about our supplements:
Laboratory tested for purityStrict adherence to GmP, HACCP and Kosher standardsLicensed and regularly inspected by The Ohio Department of AgricultureFreshly manufactured – not expired or closeout
Backed by the Muscle Feast 30-day money back guarantee
How can our Quality be so high and our prices so low? We are able to keep our pricing so low because we are a relatively small manufacturer with very low overhead and we sell direct to the public. We source the same great suppliers used by more popular brands.
Agmatine compedium – benefits, dosages and side-effects
Agmatine belongs to a group of supplements used to improve results in strength sports. Its effect on the strength potential causes it to be used more often by athletes and people practicing recreationally. There are many opinions about the effectiveness of this product. What exactly is agmatine and how does it affect the human body?
- PRIME NUTRITION Agmatine 50g
- APOLLO'S HEGEMONY Agmatine 120 caps.
What is agmatine?
Agmatine is a metabolite released in the beginning of the neuronal process. This agent is in the form of agmatine sulphate, which is involved in the processing of arginine. It is a biogenic amine (organic ammonia derivatives), which arises from the decarboxylation of amino acids.
Agmatine is found mainly in cells of the nervous system, where it is responsible for neuromodularity and muscular conduction. Due to its participation in the processes, arginine can also be found in the brain, liver, kidneys, adrenal glands and small intestine.
Another important property of agmatine is its effect on the activation of ornithine decarboxylase, which has a positive effect on the protein synthesis process. People who participate in endurance sports at different skill levels use Agmatine.
This compound is very often used in pre-workout supplements due to its stimulating effect and it causing a greater inflow of blood to the muscles. Due to an insufficient number of tests, the exact dose of this supplement is not yet precisely specified. Using agmatine in a safe dose, i.e. 1 mg per day, is recommended.
Agmatine – chemical formula
Properties of agmatine
Due to its complexity, agmatine has a wide spectrum of activity. Its main functions include:
- regulation of nitric oxide synthesis – its effect on the level of its concentration in blood,
- reduction of vascular resistance and reduction of blood pressure,
- improving the blood circulation of the muscular system,
- supporting cognitive processes,
- prevention of strokes,
Basing on our customers reviews, we highly recommend Agmatine from Apollos Hegemony, if you want to supplement this specific NO Boosting agent
- reduction of neuropathic pain,
- anxiolytic, anticonvulsive and antidepressant action,
- increasing immunity to addictive action of drugs,
- protection against the negative effects of neurotoxic compounds,
- can affect the quality of learning and memorisation by affecting the amino acid N-methyl-D-aspartate,
- may have an effect on the enhancement of the lipolysis process by affecting the adrenergic receptors
Agmatine – side effects
To date, no adverse effects have been reported as a result of taking agmatine at the recommended doses. Considering that agmatine lowers blood pressure, it is not recommended for people with hypotension.
Agmatine – reviews
There are many opinions on the effectiveness of agmatine. Most of them confirm its beneficial effect on the increase of strength or improvement of efficiency.
However, with regard to its effects on body mass and composition, these opinions are not entirely compatible and confirmed.
Despite practical support, it is presumed that agmatine may accelerate the synthesis of muscle proteins and intensify the lipolysis process. However, we still have to wait for results that are more accurate.
Why has agmatine been withdrawn?
Agmatine was withdrawn from sale despite the negative impact on the body. The reason for this decision is the problem of attributing it to a specific food category. Agmatine sulphate is not yet in any category because it is not considered a food product.
agmatine, amino acids, apollo's hegemony, brain, no booster
Agmatine benefits and side effects
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Agmatine is a well known neurotransmitter. It also works as a neuromodulator in certain processes in the body. Current research shows that agmatine has the potential to be used to treat drug addiction and reduce neuropathic pain. It can also protect the brain from the effect of toxins (1).
Agmatine was discovered over 100 years ago in 1910 by Kossel. Its mechanisms of action on different body functions though, have just been discovered. It is prepared through the removal of a carboxylic group from L-Arginine. It is naturally stored in the neurons and is therefore used in the nervous system whenever required (2).
The direct use of agmatine is not suitable for pain relief as it can elevate pain symptoms in people. The drug has an excellent synergy with most opioids and therefore, works best when combined with a painkiller morphine (3).
Agmatine affects various processes in animal neurology. It is found to inhibit the enzyme that produces nitric oxide, therefore decreasing its levels. It can also stop receptors such as N-Methyl-D-Aspartate (NMDA) and others (4).
Agmatine also has the ability to inhibit calcium channels in neurons and stop the production of specific serotonin receptors. Currently, more research is required in order to find further information on how agmatine acts within the body (5).
Agmatine’s metabolism is still not understood clearly with multiple pathways discussed to provide an explanation.
Agmatine may be handled by the Diamine Oxidase (DAO) enzyme, which is responsible for metabolizing histamine. DAO converts agmatine into 4-guanidinobutyrate (6).
This mechanism is suggested to dissolve around half of the plasma agmatine, because the inhibition of the DAO enzyme doubles the plasma concentration of the chemical.
This means that agmatine removes quickly from tissues that have high DAO levels, such as in the kidney, epithelial tissues and smooth muscle cells. They remain for a long period in the brain, liver and skeletal tissues due to the naturally lower levels of DAO (7).
10% of the agmatine can also convert into polyamines such as putrescine through different mechanisms. One mechanism produces urea as a byproduct while the other produces ammonia during the indirect conversion (8).
The current research on animals suggests that agmatine has a wide potential for use as a supplement. Some studies on humans have now appeared on the topic, but all of these employ the use of agmatine injections. It needs to be thoroughly tested for ingestion first before being termed suitable for supplement use.
Due to lack of human testing, it is not possible to discuss the toxic nature of agmatine in finer detail. It is therefore best to remain with the current dose of 2670 mg which was used in human experiments (9).
Some studies show that agmatine does not have a significant impact in providing long term pain relief. This can be a result of the short half life of agmatine in some parts of the body.
Agmatine is not effective against heat pain, and has a weak activity against visceral pain. Agmatine however, can provide pain relief in the case of neuropathic and inflammatory pain (10).
Agmatine also showed signification pain relief in a double blind study using patients that have lumbosacral spine degenerative pathologies. More research is needed in this case, because the relief continued even after discontinuing agmatine sulfate (11).
Agmatine is also known to be useful when withdrawing from alcohol. It is suggested that it helps alcohol withdrawal through a mechanism of NMDA antagonism (12).
Research shows that agmatine is very effective in protecting the body against strokes as the inhibition of the nitric oxide synthase (NOS) in the body reduces the amount of toxic nitric oxide levels (13).
Agmatine can also reduce edema which is often associated with the occurrence of a stroke. Edema refers to the condition in which fluid is lost from the arteries into the capillaries and surrounding tissues (14).
Agmatine can increase the activity of NF-kB which in turn increases the concentration of survivin inhibitor. This can save cells from hypoxia and works in contrast to apoptosis or programmed death of the cells (15).
The enzyme that produces agmatine in the body increases during stressful times. This means that it is the natural response of the body to protect it from anxiety. Agmatine increases the activity of neurons in the areas of the brain associated with the handling of stress, anxiety and depression.
Agmatine side effects
There are no general studies on the use of agmatine in humans that can be used to warrant its side effects.
Although research shows that agmatine can protect cells from acidity in the stomach, it is known to increase the chances of developing an ulcer in patients suffering from alcohol withdrawal symptoms (16).
Agmatine can increase the appetite of the person using the drug. This can be helpful for people looking to gain weight but not beneficial for obese people.
The main problem with agmatine is that sufficient research has not been carried out yet, which decreases the potential for widespread use as a health supplement.
Agmatine causes vasodilatation, therefore reducing blood pressure. It should not be used by people who are being treated for hypotension or low blood pressure (17).
There is only a single study that describes the human dosage of agmatine for the treatment of neuropathic pain as employed for daily doses of the people taking part in the experiment. The study used around 1300 to 2670 mgs of agmatine during the research phase.
The current oral dosage value is an experiment on rats, which gives an approximation of using 2-6.4 mg/Kg of body weight for humans (18).
One thing to remember though is that agmatine does not absorb well when taken with proteins. This leaves room for research to decide if the oral supplementation of agmatine is possible and carries the same benefits as its delivery through injection.
Summary: Agmatine has great potential for use in the treatment of several adverse health conditions, such as hypertension, anxiety, stress, and alcohol withdrawal symptoms. It can also be a great pain reliever, especially when used with opioids. You should always take care when taking agmatine supplements as its effects are yet to be clearly understood by research.